Pioglitazone Decreases Coronary Artery Inflammation in Impaired Glucose Tolerance and Diabetes Mellitus

Nitta, Yoshikazu; Tahara, Nobuhiro; Tahara, Atsuko; Honda, Akihiro; Kodama, Norihiro; Mizoguchi, Masahiro; Kaida, Hayato; Ishibashi, Masatoshi; Hayabuchi, Naofumi; Ikeda, Hisao; Yamagishi, Sho‐ichi; Imaizumi, Tsutomu

doi:10.1016/j.jcmg.2013.09.004

Cited by 51 publications

(32 citation statements)

References 34 publications

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“…18,19 Investigators were blinded to the clinical history and temporal sequence of the images. Subsequently, the data sets (week 0 and 12 images) were batch analyzed after coregistration of PET and CT images (Leonardo TrueD; Siemens, Forchheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

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Coronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin

Singh

Emami

Subramanian

et al. 2016

Circ: Cardiovascular Imaging

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Section: Methodsmentioning

confidence: 99%

“…7,10,17 However, successful evaluation of coronary FDG uptake has been reported previously 18 and has recently focused on the left main coronary artery (LMCA) segment, which does not have an epicardial course and thus lends itself to measurement of FDG uptake. 19 …”

mentioning

confidence: 99%

Coronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin

Singh

Emami

Subramanian

et al. 2016

Circ: Cardiovascular Imaging

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“…Preliminary studies evaluating 18 F-FDG PET/CT as a method for coronary plaque inflammation imaging have performed PET at 3 h after 18 F-FDG injection (12)(13)(14). On the other hand, studies evaluating the impact of dietary regimen on the quality of 18 F-FDG uptake suppression have performed PET at 1 h after 18 F-FDG injection (8,10).…”

mentioning

confidence: 99%

A Randomized Trial on the Optimization of ¹⁸F-FDG Myocardial Uptake Suppression: Implications for Vulnerable Coronary Plaque Imaging

et al. 2014

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18 F-FDG PET/CT can be used to detect arterial atherosclerotic plaque inflammation. However, avid myocardial glucose uptake may preclude its use for visualizing coronary plaques. Fatty acid loading or calcium channel blockers could decrease myocardial 18 F-FDG uptake, thus assisting coronary plaque inflammation identification. The present prospective randomized trial compared the efficacies of different interventions for suppressing myocardial 18 F-FDG uptake. We also investigated whether circulating free fatty acid (cFFA) levels predicted the magnitude of myocardial 18 F-FDG uptake. Methods: Thirty-six volunteers ate a high-fat low-carbohydrate meal, followed by a 12-h fasting period. They were then randomized to 1 of 4 intervention groups. Group 1 received no additional preparation and served as a reference. Groups 2 and 3, respectively, received a commercial high-fat solution containing 43.8 g of lipids or 50 mL of olive oil 1 h before 18 F-FDG injection to evaluate the impact of fatty acid loading on myocardial 18 F-FDG uptake. Group 4 received verapamil to evaluate the effect of calcium channel blockers. Cardiac PET/CT was performed after administration of 370 MBq of 18 F-FDG. Myocardial uptake suppression was assessed using a qualitative visual scale and by measuring the myocardial maximum standardized uptake value (SUV max ). Insulin, glucose, and cFFA were serially measured. Results: The qualitative visual scale showed good myocardial 18 F-FDG uptake suppression in 8 of 9, 5 of 9, 4 of 9, and 8 of 9 subjects of groups 1, 2, 3, and 4, respectively (P 5 0.09). SUV max did not significantly differ between groups (P 5 0.17). Interestingly, cFFA levels were higher in volunteers with good suppression (0.80 ± 0.31 mmol/L) than in those with poor suppression (0.53 ± 0.15 mmol/L; P 5 0.011). We found an inverse correlation between cFFA level (measured at 18 F-FDG injection) and the SUV max (R 5 0.61). Receiver-operating-characteristic curve analysis identified 0.65 mmol/L cFFA as the best cutoff value to predict adequate 18 F-FDG uptake suppression (positive predictive value, 89%). Conclusion: A high-fat low-carbohydrate meal followed by a 12-h fasting period effectively suppressed myocardial 18 F-FDG uptake in most subjects. Neither complementary fatty acid loading nor verapamil administered 1 h before 18 F-FDG injection conferred any additional benefit. Myocardial 18 F-FDG uptake was inversely correlated with cFFA level, representing an interesting way to predict myocardial 18 F-FDG uptake suppression.

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“…As a result, there is an increasing interest toward evaluating molecular activity of the plaques. There are some reports on the capability of FDG-PET/ CT to visualize coronary artery atherosclerosis in diabetic patients 46 and atherosclerosis plaques before 96,97 and after stenting. 57 Despite the potential applicability of this technique, there are some concerns with its applications for visualizing the coronary arteries.…”

Section: Evaluation Of Coronary Arteries Atherosclerosis Using Fdg-pementioning

confidence: 99%

“…Finally, resources should be utilized for developing specialized PET/CT machines with increased spatial resolution for evaluating small arteries. 46 …”

Section: Evaluation Of Coronary Arteries Atherosclerosis Using Fdg-pementioning

confidence: 99%

Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification

Gholami

Salavati

Houshmand

et al. 2015

Journal of Nuclear Cardiology

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There is growing evidence showing the importance of fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of vessel wall inflammation and atherosclerosis. Although this imaging modality has been increasingly used, there are various methods for image acquisition and evaluating FDG uptake activity in the vessel walls and atherosclerotic lesions, including qualitative visual scaling, semi-quantitative, and quantitative evaluations. Using each of these image acquisition protocols and measurement methods may result in different findings. In this review, we are going to describe the various image acquisition methods and common measurement strategies reflected in the literature and discuss their advantages and flaws.

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Pioglitazone Decreases Coronary Artery Inflammation in Impaired Glucose Tolerance and Diabetes Mellitus

Cited by 51 publications

References 34 publications

Coronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin

Coronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin

A Randomized Trial on the Optimization of ¹⁸F-FDG Myocardial Uptake Suppression: Implications for Vulnerable Coronary Plaque Imaging

Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification

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Pioglitazone Decreases Coronary Artery Inflammation in Impaired Glucose Tolerance and Diabetes Mellitus

Cited by 51 publications

References 34 publications

Coronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin

Coronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin

A Randomized Trial on the Optimization of 18F-FDG Myocardial Uptake Suppression: Implications for Vulnerable Coronary Plaque Imaging

Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification

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A Randomized Trial on the Optimization of ¹⁸F-FDG Myocardial Uptake Suppression: Implications for Vulnerable Coronary Plaque Imaging