Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells

Zhu, Kongbo; Qian, Linglin; Lin, Yanshan; An, Li; Mu, Guangjian; Ma, Genshan; Ren, Liqun

doi:10.1155/2019/5245063

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Pioglitazone is both a PPARγ and FFAR1 agonist [2, 5, 29]. However, the effect of pioglitazone on the FFAR1 and its downstream signals like β-arrestin2 is not well characterized.…”

Section: Discussionmentioning

confidence: 99%

Pioglitazone Enhances β-Arrestin2 Signaling and Ameliorates Insulin Resistance in Classical Insulin Target Tissues

et al. 2021

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Introduction: Pioglitazone is a thiazolidinedione oral antidiabetic agent. This study aimed to investigate the effects of pioglitazone as insulin sensitizer on β-arrestin2 signaling in classical insulin target tissues. Methods: Experiments involved three groups of mice; the first one involved mice fed standard chow diet for 16 weeks; the second one involved mice fed high-fructose, high-fat diet (HFrHFD) for 16 weeks; and the third one involved mice fed HFrHFD for 16 weeks and received pioglitazone (30 mg/kg/day, orally) in the last four weeks of feeding HFrHFD. Results: The results showed significant improvement in the insulin sensitivity of pioglitazone-treated mice as manifested by significant reduction in the insulin resistance index. This improvement in insulin sensitivity was associated with significant increases in the β-arrestin2 levels in the adipose tissue, liver, and skeletal muscle. Moreover, pioglitazone significantly increased β-arrestin2 signaling in all the examined tissues as estimated from significant increases in phosphatidylinositol 4,5 bisphosphate and phosphorylation of Akt at serine 473 and significant decrease in diacylglycerol level. Conclusion: To the best of our knowledge, our work reports a new mechanism of action for pioglitazone through which it can enhance the insulin sensitivity. Pioglitazone increases β-arrestin2 signaling in the adipose tissue, liver, and skeletal muscle of HFrHFD-fed mice.

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“…Pioglitazone is both a PPARγ and FFAR1 agonist [2, 5, 29]. However, the effect of pioglitazone on the FFAR1 and its downstream signals like β-arrestin2 is not well characterized.…”

Section: Discussionmentioning

confidence: 99%

Pioglitazone Enhances β-Arrestin2 Signaling and Ameliorates Insulin Resistance in Classical Insulin Target Tissues

et al. 2021

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The Role of Statins (HMG-CoA Reductase Inhibitors) on Insulin Secretion from the Islets of Langerhans: A Systematic Review

Ashrafizadeh

Oroojan

Ahmadi

et al. 2022

Jentashapir J Cell Mol Biol

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Context: Statins are administered to decrease atherosclerosis in patients with coronary heart disease. These drugs enhance the risk of diabetes by affecting islets insulin secretion. Objectives: Therefore, this systematic review investigates the effect of statins on insulin secretion of islets of Langerhans in the related original studies. Methods: A preliminary search was performed in the PubMed, Scopus, Web of Science, and ProQuest databases. The search strategy terms were statin (hydroxymethylglutaryl-CoA reductase inhibitors), insulin secretion, and islets of Langerhans. The search elements were evaluated using the Mesh term system. Limits were used to include only review articles and no limits were set on language. The quality of the method and risk of bias was assessed by its tool. Results: After removing irrelevant articles to the subject, 20 articles fulfilled the inclusion criteria. In vivo studies revealed that pravastatin and rosuvastatin increase and decrease islets insulin secretion, while atorvastatin and fluvastatin reduced this variable, and pitavastatin had no effect. The results of in vitro studies showed that pravastatin and induced both increasing and decreasing effects on insulin secretion from the pancreatic islet cells. Also, administration of atorvastatin, rosuvastatin, fluvastatin, pitavastatin, simvastatin, and lovastatin decreased islet insulin secretion in the medium. Conclusions: Pravastatin could enhance pancreatic islet insulin secretion while other statins reduced this variable. Finally, the contradictory effect of statins on islets’ insulin secretion can indicate the existence of laboratory and clinical research in this regard.

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Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells

Cited by 2 publications

References 33 publications

Pioglitazone Enhances β-Arrestin2 Signaling and Ameliorates Insulin Resistance in Classical Insulin Target Tissues

Pioglitazone Enhances β-Arrestin2 Signaling and Ameliorates Insulin Resistance in Classical Insulin Target Tissues

The Role of Statins (HMG-CoA Reductase Inhibitors) on Insulin Secretion from the Islets of Langerhans: A Systematic Review

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