Pío del Río‐Hortega: The Revolution of Glia

Bereciartu, Juan Del Río-Hortega

doi:10.1002/ar.24266

Cited by 20 publications

(14 citation statements)

References 11 publications

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“…Microglia are CNS-resident macrophages, initially described by Pio del Rio Ortega [ 10 ]. These cells, in addition to homeostatic functions, constitute the frontline defense of the innate immune system.…”

Section: Role Of Microgliamentioning

confidence: 99%

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Pajares

Rojo

Manda

et al. 2020

Cells

446

296

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Parkinson’s disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta. Although the molecular bases for PD development are still little defined, extensive evidence from human samples and animal models support the involvement of inflammation in onset or progression. However, the exact trigger for this response remains unclear. Here, we provide a systematic review of the cellular mediators, i.e., microglia, astroglia and endothelial cells. We also discuss the genetic and transcriptional control of inflammation in PD and the immunomodulatory role of dopamine and reactive oxygen species. Finally, we summarize the preclinical and clinical approaches targeting neuroinflammation in PD.

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Section: Role Of Microgliamentioning

confidence: 99%

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Pajares

Rojo

Manda

et al. 2020

Cells

446

296

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show abstract

“…Consequently, in the 1920s, he was one of the most relevant neuroscientists in the world and his figure attracted many outstanding disciples, as the American neuropathologist and neurosurgeon Wilder S. Penfield (Penfield, 1924(Penfield, , 1977del Río-Hortega and Penfield, 1927; see also de Castro, 1981de Castro, , 2019del Río-Hortega Bereciartu, 2020). Pío del Río-Hortega was proposed by first time for the Nobel Prize in Physiology or Medicine 1929 1 because of his "work on the histology and histopathology of the nervous system, especially studies of glial tissue (microglia and oligodendroglia)" (de Castro, 2019;del Río-Hortega Bereciartu, 2020). Escaping from the Spanish Civil War (1936)(1937)(1938)(1939) first, and the 2nd World War (1939)(1940)(1941)(1942)(1943)(1944)(1945) later, Río-Hortega continued researching out of Spain up to his death.…”

Section: Introductionmentioning

confidence: 99%

Women Neuroscientist Disciples of Pío del Río-Hortega: the Cajal School Spreads in Europe and South America

et al. 2021

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Pio del Rio-Hortega was not only the discoverer of the microglia and oligodendroglia but also possibly the most prolific mentor of all Santiago Ramon y Cajal’s disciples (Nobel awardee in Physiology or Medicine 1906 and considered as the father of modern Neuroscience). Among Río-Hortega’s mentees, three exceptional women are frequently forgotten, chronologically: Pio’s niece Asunción Amo del Río who worked with Río-Hortega at Madrid, Paris, and Oxford; the distinguished British neuropathologist Dorothy Russell who also worked with Don Pío at Oxford; and Amanda Pellegrino de Iraldi, the last mentee in his career. Our present work analyzes the figures of these three women who were in contact and collaborated with Don Pío del Río-Hortega, describing the influences received and the impact on their careers and the History of Neuroscience. The present work completes the contribution of women neuroscientists who worked with Cajal and his main disciples of the Spanish Neurological School both in Spain (previous work) and in other countries (present work).

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“…In this case, it was his grandnephew, Juan del Río‐Hortega Bereciartu who addressed this figure and his work. Indeed, most notable of Río‐Hortega's discoveries was the description of two of the three types of glia that exist in the brain, oligodendroglia and microglia, a finding that complied a hundred years last year (Río‐Hortega Bereciartu, ).…”

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confidence: 99%

The History of Spanish Neuroscience: Thematic Papers Issue

Carlos

2020

The Anatomical Record

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To commemorate the 100th anniversary of the creation of the Instituto Cajal, we bring this thematic issue to honor Spanish neuroscience. The issue includes several papers written by scientists, most of them being direct descendants of those who lived on the front lines of the dawn of Spanish neuroscience. These pages reflect a summary of the main achievements of this unique group of neuroscientists, all of them belonging to the Cajal School. Finally, this school of scientists became the forerunner of the modern worldwide neuroscience.

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Pío del Río‐Hortega: The Revolution of Glia

Abstract: Pío del Río-Hortega (Portillo, 1882-Buenos Aires 1945) was a Spanish pioneer scientist. Here, we highlight his professional merits and scientific qualities, facets that permitted him to open the eyes of the scientific community to the existence of microglia and oligodendroglia.

Cited by 20 publications

References 11 publications

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Women Neuroscientist Disciples of Pío del Río-Hortega: the Cajal School Spreads in Europe and South America

The History of Spanish Neuroscience: Thematic Papers Issue

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