Pinostrobin modulates FOXO3 expression, nuclear localization, and exerts antileukemic effects in AML cells and zebrafish xenografts

Chen, Pei-Yi; Lin, Ching-Yen; Wu, Chia-Ling; Keak, Pei Ying; Liou, Je-Wen; Gao, Wan-Yun; Lin, Liang-In; Yen, Jui-Hung

doi:10.1016/j.cbi.2023.110729

Cited by 2 publications

(2 citation statements)

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“…47 Pinostrobin exhibits promising potential for leukemia treatment. 44,48,49 For example, pinostrobin inhibits miR-410-5p, thereby increasing β-catenin degradation and the expression of SFRP5, which inhibits the Wnt/β-catenin signaling pathway. Furthermore, pinostrobin increased the expression levels of key apoptosis mediators Bax, caspase-3, and BAK while decreasing the anti-apoptotic proteins BCL-2, BCL-W, and MCL-1.…”

Section: Anticancer Effectsmentioning

confidence: 99%

“…These effects of pinostrobin ultimately induce apoptosis in NB4 and MOLT-4 acute leukemia cells. 48,49 GO enrichment analysis revealed that pinostrobin is closely associated with terms related to the regulation of cancer cell progression including programmed cell death, hemopoiesis, cell differentiation, inflammatory response, DNA replication, chromosome segregation, and cell cycle checkpoints. Pinostrobin upregulates FOXO3 expression and nuclear translocation.…”

Section: Anticancer Effectsmentioning

confidence: 99%

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Research Progress on the Pharmacological Effects and Molecular Mechanisms of Pinostrobin

Wang,

Zhao,

Chen

et al. 2023

Natural Product Communications

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Pinostrobin (5-hydroxy-7-methoxyflavanone) is an active flavonoid substance. It is widely present in many traditional Chinese herbs, including Carya cathayensis leaves, Boesenbergia rotunda and propolis. Pinostrobin possesses many pharmacological activities without significant toxicity. In addition to anti-inflammatory and antioxidant effects, pinostrobin also exerts antitumor effects. Pinostrobin is able to protect against infection by several viruses, bacteria, fungi, and parasites. Pinostrobin reduces the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), which is a promising target of lipid-lowering drugs. It also reduces high uric acid levels while not affecting the normal uric acid levels. Furthermore, it has protective effects on the liver, kidney, bone, skin, reproductive system, stomach and nerves. Due to its multifunctional effects and safety, pinostrobin has advantages for development as a novel drug for clinical application. Based on this, this current article summarized the research progress on the pharmacological effects and mechanisms of pinostrobin, to provide a reference for further development.

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