Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF-κB signaling in pressure overload-induced rats

Chen, Yusha; Pan, Ruiyan; Zhang, Juanjuan; Liang, Tu; Guo, Juan; Sun, Tong; Fu, Xiaoyan; Wang, Ling; Zhang, Lane

doi:10.1016/j.jep.2021.113920

Cited by 26 publications

(16 citation statements)

References 33 publications

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“…Excessive secretion of inflammatory cytokines, such as TNF-α, IL-1β, and inflammatory mediators, for example, NO, iNOS have been proved to lead to inflammation, and NF-κB, the key transcription factor of inflammation, regulates the secretion of inflammatory cytokines ( An et al, 2020 ; Chen et al, 2021 ). In our study, our results showed that FF markedly reduced the levels of inflammatory cytokines, inflammatory mediators, and the protein expression levels of phosphorylated total IKKα/β and nuclear NF-κB, and the inhibitory effects of FF from Shaanxi on IKKα/β and NF-κB were higher than those of FF from Shanxi, indicating that the anti-inflammatory of FF from Shanxi and Shaanxi in August may be related to NF-κB signaling, and the activity of FF from Shaanxi is higher than that of FF from Shanxi.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Forsythiae Fructus From Different Harvest Seasons and Regions by HPLC/NIR Analysis and Anti-inflammatory and Antioxidant Assays

Dong

et al. 2021

Front. Pharmacol.

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Forsythiae Fructus (FF), the dry fruit of Forsythia suspensa (Thunb.) Vahl, has a long history of use in traditional Chinese Medicine for its heat-clearing and detoxifying properties. It possesses clinical therapeutic effects and biological functions showing efficacy in handling different diseases. To investigate the FF differences in Henan, Shanxi, and Shaanxi in August and October, the surface morphology, mid-infrared and near-infrared spectrums, and HPLC were analyzed. Concurrently, the anti-inflammatory and antioxidant effects on LPS-induced J774A.1 cells were evaluated by western blot and RT-qPCR. The results showed that FF from different Harvest Seasons and Regions are provided with different microstructures and mid-infrared and near-infrared spectrums, and the levels of forsythiaside A and phillyrin of FF from Shanxi in August and phillygenin of FF from Shaanxi in August were the highest. Meanwhile, FF from Shanxi and Shaanxi in August markedly reduced the levels of inflammatory cytokines and mediators (TNF-α, IL-1β, NF-κB, and iNOS) and the protein expression levels of phosphorylated total IKKα/β and nuclear NF-κB. In August, SXFF and SAXFF also promoted the mRNA expression levels of HO-1 and NQO1 and the protein expression levels of HO-1 and nuclear Nrf2 and suppressed the protein expression levels of KEAP1. Spearman correlation analysis showed that phillygenin had a strong correlation with the protein expression on LPS-induced J774A.1 cells. In summary, our results showed that FF from harvest seasons and regions contributed to the distinct differences in microstructure, the mid-infrared and near-infrared spectrums, and compound content. More importantly, FF from Shanxi and Shaanxi in August showed marked anti-inflammatory and antioxidant activities, but with some differences, which may be because of different contents of phillygenin and phillyrin of lignans in FF.

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Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Forsythiae Fructus From Different Harvest Seasons and Regions by HPLC/NIR Analysis and Anti-inflammatory and Antioxidant Assays

Dong

et al. 2021

Front. Pharmacol.

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“…Persistent hypertrophy leads to cardiac decompensation and systolic dysfunction and exacerbates ventricular remodeling, leading to HF [220]. Multiple natural small molecules treat cardiac hypertrophy through different targets [186][187][188][189][190][191][192][193][194][195][196][197][198][199][200][201][202]; for example, quercetin protects mitochondrial function and inhibits cardiac hypertrophy through SIRT3/PARP-1 signaling [182,184,186,188]. Triptolide increased CDK1 and CDK4 mRNA, CDK1, p21 and p27 mRNA expression [185].…”

Section: Myocardial Hypertrophymentioning

confidence: 99%

Mechanisms of action of natural small-molecule drugs in cardiovascular disease

SUN

Luo

et al. 2022

Preprint

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Cardiovascular diseases (CVDs) cause massive morbidity and mortality. In recent years, natural small-molecule therapeutics have attracted much attention for their significant efficacy. Articles have been published to study the intervention of natural drugs (including monomers, compounds, compound and neo-combinations) on one type of cardiovascular disease, but the number and variety of natural drugs included are small and insufficient, and there are no articles detailing the protective effects of different types of natural small molecule drugs on multiple cardiovascular diseases. Natural small molecule drugs have high biological activity and structural diversity, and are more likely to enter the body to exert their effects. In this article, we describe the efficacy of such drugs for anti-atherosclerosis, cardiomyocyte repair, and antagonism of ventricular remodeling, heart failure, and arrhythmias to provide an experimental basis for clinical research and identification of new therapeutic approaches.

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“…Last decade has extensively investigated the anti-inflammatory activities of E. ulmoides in distinct inflammatory disease models, involving septic inflammation and autoimmune diseases [ 33 – 37 ]. Of note, E. ulmoides may be a promising candidate in treating neuroinflammation, as the active components isolated from E. ulmoides , such as aucubin, has been profoundly demonstrated alleviating neuroinflammation in Parkinson’s disease, Alzheimer’s disease and seizures in vivo [ 38 – 40 ]. Except for the anti-neuroinflammatory activities covered in the neuroprotective section, the rest of the anti-inflammatory activities and its mechanisms were discussed in the following.…”

Section: Biological Activities Of E Ulmoidesmentioning

confidence: 99%

“…Their IC 50 of DPPH radical scavenging capacity were assessed and listed in Table 2 . Apart from that, geniposide, aucubin and PG have also been reported alleviating oxidative stress and their antioxidant effects through regulation of Nrf2/HO-1 pathways [ 38 , 74 – 79 ]. They were probably the critical compounds in the mechanism of antioxidant potency formation in E. ulmoides , but not all of them.…”

Section: Biological Activities Of E Ulmoidesmentioning

confidence: 99%

Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.

et al. 2021

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As a Traditional Chinese Medicine, Eucommia ulmoides Oliv. has been used for the treatment of various diseases since ancient times, involving lumbar pain, knee pain, osteoporosis, hepatoprotection, paralysis, intestinal haemorrhoids, vaginal bleeding, abortion, spermatorrhoea, foot fungus, anti-aging etc. With the developing discovery of E. ulmoides extracts and its active components in various pharmacological activities, E. ulmoides has gained more and more attention. Up to now, E. ulmoides has been revealed to show remarkable therapeutic effects on hypertension, hyperglycemia, diabetes, obesity, osteoporosis, Parkinson’s disease, Alzheimer’s disease, sexual dysfunction. E. ulmoides has also been reported to possess antioxidant, anti-inflammatory, neuroprotective, anti-fatigue, anti-aging, anti-cancer and immunoregulation activities etc. Along these lines, this review summarizes the traditional application and modern pharmacological research of E. ulmoides, providing novel insights of E. ulmoides in the treatment of various diseases.

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Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF-κB signaling in pressure overload-induced rats

Cited by 26 publications

References 33 publications

Comparative Evaluation of Forsythiae Fructus From Different Harvest Seasons and Regions by HPLC/NIR Analysis and Anti-inflammatory and Antioxidant Assays

Comparative Evaluation of Forsythiae Fructus From Different Harvest Seasons and Regions by HPLC/NIR Analysis and Anti-inflammatory and Antioxidant Assays

Mechanisms of action of natural small-molecule drugs in cardiovascular disease

Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.

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