Pinoresinol diglucoside exhibits protective effect on dexamethasone-induced osteoporosis in rats

Zhang, Zhanfeng; Min, Ji-Kang; Wang, Dan; Zhong, Jian-Ming

doi:10.4314/tjpr.v15i11.21

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…These three diglucosides were present in sesame seeds in comparable concentrations. However, only the latter compound, with glucose molecules attached to different methoxyphenol moieties of pinoresinol, was used in all biomedical studies on pinoresinol diglucoside that we are aware of (e.g., [ 107 , 108 , 109 ]).…”

Section: Chemistry Of Sesame Lignansmentioning

confidence: 99%

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Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

et al. 2021

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Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans. Sesamol, sesaminol, its epimers, and episesamin are transformation products found in processed products. Synthetic routes to all lignans are known but only sesamol is synthesized industrially. Biosynthesis of furofuran lignans begins with the dimerization of coniferyl alcohol, followed by the formation of dioxoles, oxidation, and glycosylation. Most genes of the lignan pathway in sesame have been identified but the inheritance of lignan content is poorly understood. Health-promoting properties make lignans attractive components of functional food. Lignans enhance the efficiency of insecticides and possess antifeedant activity, but their biological function in plants remains hypothetical. In this work, extensive literature including historical texts is reviewed, controversial issues are critically examined, and errors perpetuated in literature are corrected. The following aspects are covered: chemical properties and transformations of lignans; analysis, purification, and total synthesis; occurrence in Seseamum indicum and related plants; biosynthesis and genetics; biological activities; health-promoting properties; and biological functions. Finally, the improvement of lignan content in sesame seeds by breeding and biotechnology and the potential of hairy roots for manufacturing lignans in vitro are outlined.

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Section: Chemistry Of Sesame Lignansmentioning

confidence: 99%

“…Pinoresinol diglucoside alleviated osteoporosis in rats [ 107 ]; unfortunately, only one of the three isomers was tested (see Section 2.1.4 ). Sesamol can protect cartilage against degradation (chondroprotective effect) [ 359 ].…”

Section: Biological Activities Of Lignansmentioning

confidence: 99%

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

et al. 2021

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“…Osteoporosis is a chronic bone disease characterized by decreased bone mass or bone mineral density (BMD), deterioration of bone architecture, and enhanced susceptibility to fracture. Osteoporosis disease is the most critical health issue after cardiovascular disease (1)(2)(3). The frequency of osteoporosis has increased worldwide.…”

Section: Introductionmentioning

confidence: 99%

Antiosteoporosis and bone protective effect of dieckol against glucocorticoid-induced osteoporosis in rats

2022

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BackgroundGlucocorticoids (GCs) induce osteoporosis, which results in fractures in the bond, causing significant morbidity. In the conducted study, we examined the antiosteoporosis effect of dieckol against GC-induced osteoporosis in rats.MethodsSprague–Dawley (SD) rats were used for the current study and dexamethasone (2.5 mg/kg) induced osteoporosis in the rats that received the dieckol (test) and alendronate (standard) for 20 weeks. Bone turnover parameters, microCT, antioxidant, inflammatory cytokines, nutrient, and hormones parameters.ResultsDieckol noticeably suppressed the body weight and boosted the uterine and vagina weight. Dieckol considerably altered the level of trabecular number (Tb. N), the bone volume to total volume (BV/TV), trabecular separation (Tb.Sp), bone surface to bone volume (BS/BV), and trabecular thickness (Tb.Th). Dieckol noticeably (P < 0.001) elevated the level of osteocalcin (OC) and alleviated the level of bone Gla protein (BGP), acid phosphatase (ACP), alkaline phosphatase (ALP), and β-CTx. Dieckol markedly boosted the level of malondialdehyde (MDA) and suppressed the level of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) along with the suppression of inflammatory cytokines like TNF-α, IL-1β, and IL-6. Dieckol remarkably increased the level of calcium, potassium, magnesium, and 25 (OH) vitamin D. Dieckol substantially (P < 0.001) boosted the level of estradiol and alleviated the level of parathyroid hormone and tartrate-resistant acid phosphatase (TRAP). Dieckol also suppressed the level of receptor activator of nuclear factor κB ligand (RANKL) and boosted the level of osteoprotegerin (OPG).ConclusionTaken together, our data suggest that dieckol demonstrated the anti-osteoporosis effect against GC-induced osteoporosis in rats.

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“…Phenylethanoid glucosides were more abundant than the other phytochemical groups. Chlorogenic acid, forsythoside A, pinoresinol diglucoside, quercetin, rutin, and salidroside have been shown to exert anti-osteoporotic and anti-osteolytic effects in animal models [28,29,30,31,32,33], and other studies have reported the inhibitory effects of chlorogenic acid, forsythoside A, matairesinol, quercetin, and rutin on osteoclast differentiation [28,30,34,35]. However, forsythoside B, forsythoside E, forsythin, phillygenin, and pinoresinol glucoside have not been reported in bone metabolism.…”

Section: Resultsmentioning

confidence: 99%

Forsythia suspensa Protects against Bone Loss in Ovariectomized Mice

et al. 2019

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In traditional oriental medicine, the fruit of Forsythia suspensa has been used as a nutritional supplement to alleviate inflammation and treat gastrointestinal diseases. However, there is no information available on its beneficial effects on bone. We investigated the beneficial effects of F. suspensa water extract (WFS) on osteoclast differentiation and bone loss. The microarchitecture of trabecular bone was analyzed by micro-computed tomography. Osteoclast differentiation was evaluated based on tartrate-resistant alkaline phosphatase activity, and bone resorption activity was examined on a bone-like mineral surface. The mechanism of action of WFS was assessed by evaluating the expression and activation of signaling molecules. Phytochemical constituents were identified and quantitated by ultrahigh-performance liquid chromatography–tandem mass spectrometry. WFS reduced ovariectomy-induced trabecular bone loss and inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation and resorption activity. WFS suppressed RANKL-induced expression of nuclear factor of activated T cells cytoplasmic 1, a crucial transcription factor for osteoclast differentiation by decreasing c-Fos protein levels and suppressing the activation of p38 and c-Jun-N-terminal kinase. We also identified 12 phytochemicals in WFS including lignans, phenylethanoids, and flavonoids. Collectively, these results suggest that WFS inhibits osteoclast differentiation and can potentially be used to treat postmenopausal osteoporosis.

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Pinoresinol diglucoside exhibits protective effect on dexamethasone-induced osteoporosis in rats

Abstract: , ,

Cited by 10 publications

References 22 publications

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

Antiosteoporosis and bone protective effect of dieckol against glucocorticoid-induced osteoporosis in rats

Forsythia suspensa Protects against Bone Loss in Ovariectomized Mice

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