PINK1: pumps, paraesthesia, punding and psychosis

Paviour, Dominic; Marion, Marie-Hélène

doi:10.1007/s00415-011-6327-z

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…Psychosis in this condition was reported in isolated cases and included visual hallucinations, paranoid and grandiose delusions, as well as hyper‐religiosity . Visual hallucinations were usually associated to DRT and were also observed in the context of grandiose delusions and impulse control . In a few cases, visual hallucinations were associated with dementia .…”

Section: Resultsmentioning

confidence: 99%

“…In a few cases, visual hallucinations were associated with dementia . Treatment with high doses of quetiapine or clozapine showed good efficacy in some cases …”

Section: Resultsmentioning

confidence: 99%

“…[26][27][28][29][30] Visual hallucinations were usually associated to DRT [22][23][24][25] and were also observed in the context of grandiose delusions and impulse control. 31,32 In a few cases, visual hallucinations were associated with dementia. 23,24,29 Treatment with high doses of quetiapine or clozapine showed good efficacy in some cases.…”

Section: Park-pink1mentioning

confidence: 99%

“…23,24,29 Treatment with high doses of quetiapine or clozapine showed good efficacy in some cases. 31,32…”

Section: Park-pink1mentioning

confidence: 99%

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Nosology and Phenomenology of Psychosis in Movement Disorders

Rossi

Farcy

Starkstein

et al. 2020

Movement Disord Clin Pract

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Background Background: Psychotic symptoms, such as delusions and hallucinations, are part of the clinical picture of several conditions presenting movement disorders. Phenomenology and epidemiology of psychosis in Parkinson's disease have received wide attention; however, the presence of psychosis in other movement disorders is, comparatively, less well known. Objectives Objectives: To review psychotic symptoms present in different movement disorders. Methods Methods: A comprehensive and structured literature search was performed to identify and analyze data on patients with movement disorders and comorbid psychosis.

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Section: Resultsmentioning

confidence: 99%

“…In a few cases, visual hallucinations were associated with dementia . Treatment with high doses of quetiapine or clozapine showed good efficacy in some cases …”

Section: Resultsmentioning

confidence: 99%

Section: Park-pink1mentioning

confidence: 99%

“…23,24,29 Treatment with high doses of quetiapine or clozapine showed good efficacy in some cases. 31,32…”

Section: Park-pink1mentioning

confidence: 99%

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Nosology and Phenomenology of Psychosis in Movement Disorders

Rossi

Farcy

Starkstein

et al. 2020

Movement Disord Clin Pract

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“…For three years, the motor response was satisfactory, but she required B6 vitamin replacement for sensory axonal polyneuropathy. Four years after LCIG, she developed marked dyskinesias, dopamine dysregulation syndrome, ICD, and punding [ 107 ].…”

Section: Evidence On the Use Of Levodopa Carbidopa Intestinal Gelmentioning

confidence: 99%

A Review on Response to Device-Aided Therapies Used in Monogenic Parkinsonism and GBA Variants Carriers: A Need for Guidelines and Comparative Studies

Salles

Liao

Shuaib

et al. 2022

JPD

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Parkinson’s disease (PD) is in some cases predisposed-or-caused by genetic variants, contributing to the expression of different phenotypes. Regardless of etiology, as the disease progresses, motor fluctuations and/or levodopa-induced dyskinesias limit the benefit of pharmacotherapy. Device-aided therapies are good alternatives in advanced disease, including deep brain stimulation (DBS), levodopa-carbidopa intestinal gel, and continuous subcutaneous infusion of apomorphine. Candidate selection and timing are critical for the success of such therapies. Genetic screening in DBS cohorts has shown a higher proportion of mutation carriers than in general cohorts, suggesting that genetic factors may influence candidacy for advanced therapies. The response of monogenic PD to device therapies is not well established, and the contribution of genetic information to decision-making is still a matter of debate. The limited evidence regarding gene-dependent response to device-aided therapies is reviewed here. An accurate understanding of the adequacy and responses of different mutation carriers to device-aided therapies requires the development of specific studies with long-term monitoring.

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Punding in Parkinson's Disease: An Update

Rajalingam

Fasano

2023

Movement Disord Clin Pract

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Background Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, non‐goal oriented, repetitive activity affecting individuals with Parkinson's disease (PD) on dopamine replacement therapy (DRT). Objectives In 2010, we published the first review focused on the pathophysiology of punding. This study aims to systematically review the literature of the past decade on punding in PD, particularly focusing on the clinical features, underlying pathophysiological mechanisms, and treatment. Methods Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, we searched PubMed, Embase, and APA PsycInfo for articles published between July 1, 2010 and March 19, 2022. The search strategy included: (punding) AND (parkinson*). Results Of 256 studies identified, 29 were eligible for inclusion with 19 original research articles and 10 case reports. This review confirmed that predictors of punding in PD are higher doses of DRT, younger age, male sex, and increasing disease severity. We also found an association between punding and psychiatric and/or cognitive symptoms. Neuroimaging studies have showed that punding in PD is associated with a disconnection between midbrain, limbic and white matter tracts projecting to the frontal cortices and a breakdown of the connectivity among the crucial nodes of the reward circuit. Low‐frequency repetitive transcranial magnetic stimulation on the dorsolateral prefrontal cortex has been shown to produce a transient beneficial effect in PD patients with punding. Conclusion In conclusion, although the clinical features of punding have been established, in the past 12 years, we gained a better understanding of the pathophysiological mechanisms of punding, mainly thanks to magnetic resonance imaging techniques.

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PINK1: pumps, paraesthesia, punding and psychosis

Cited by 4 publications

References 7 publications

Nosology and Phenomenology of Psychosis in Movement Disorders

Nosology and Phenomenology of Psychosis in Movement Disorders

A Review on Response to Device-Aided Therapies Used in Monogenic Parkinsonism and GBA Variants Carriers: A Need for Guidelines and Comparative Studies

Punding in Parkinson's Disease: An Update

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