Pink Urine Syndrome

Okubo, Kentaro; Okubo, H; Kamijo, Yuji; Higuchi, Makoto

doi:10.2169/internalmedicine.50.5972

Cited by 4 publications

(3 citation statements)

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“…The mechanism of pink urine remains unclear. It has been postulated that stress-related secretions of antidiuretics hormones increase the renal clearance of uric acid and cause uric acid crystalluria, which turns urine pink [ 145 – 147 ]. Indeed, obesity, especially with metabolic syndrome, may impair alkalinization of urine and thereby lead to the precipitation of uric acid.…”

Section: Propofol Metabolism and Related Urine Discolorationmentioning

confidence: 99%

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Dinis-Oliveira

2018

BioMed Research International

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Propofol is an intravenous short-acting anesthetic widely used to induce and maintain general anesthesia and to provide procedural sedation. The potential for propofol dependency and abuse has been recognized, and several cases of accidental overdose and suicide have emerged, mostly among the health professionals. Different studies have demonstrated an unpredictable interindividual variability of propofol pharmacokinetics and pharmacodynamics with forensic and clinical adverse relevant outcomes (e.g., pronounced respiratory and cardiac depression), namely, due to polymorphisms in the UDP-glucuronosyltransferase and cytochrome P450 isoforms and drugs administered concurrently. In this work the pharmacokinetics of propofol and fospropofol with particular focus on metabolic pathways is fully reviewed. It is concluded that knowing the metabolism of propofol may lead to the development of new clues to help further toxicological and clinical interpretations and to reduce serious adverse reactions such as respiratory failure, metabolic acidosis, rhabdomyolysis, cardiac bradyarrhythmias, hypotension and myocardial failure, anaphylaxis, hypertriglyceridemia, renal failure, hepatomegaly, hepatic steatosis, acute pancreatitis, abuse, and death. Particularly, further studies aiming to characterize polymorphic enzymes involved in the metabolic pathway, the development of additional routine forensic toxicological analysis, and the relatively new field of ‘‘omics” technology, namely, metabolomics, can offer more in explaining the unpredictable interindividual variability.

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Section: Propofol Metabolism and Related Urine Discolorationmentioning

confidence: 99%

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Dinis-Oliveira

2018

BioMed Research International

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“…dependent diabetes, hypercholesterolemia, OSA, CHF, depression, carpal-tunnel syndromeOkubo K, et al . 2011 Japan [95]44 - Male–6––No AKILiver hepatoma removalStern AB, et al . 2010 USA [96]53 - Female55.5 (postoperative)YesNo AKIAdmitted for debulking surgery for ovarian serous adenocarcinoma; HTN, unspecified nephrolithiasisSchmitt R, et al .…”

Section: Case Presentationmentioning

confidence: 99%

Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol

Tucker

Perazella

2019

Kidney International Reports

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Pink urine syndrome is mostly seen in patients treated with propofol anesthesia. The pink color is attributed to the presence of large concentrations of uric acid (and pigment), which is excreted in large amounts when propofol is given. We describe a case of propofol-induced pink urine syndrome and perform a comprehensive, evidence-based review. We discuss prior case studies already published in the literature as we speculate on the pathophysiology and how it translates to a clinically relevant entity.

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“…De igual forma, otras condiciones pueden condicionar un efecto uricosúrico, como las cirugías abdominales y la presencia de tumores o cáncer. Asimismo, los pacientes con síndrome metabólico u obesidad, así como aquellos con hiperuricemia o gota, pueden presentar síndrome de la orina rosa por incremento en la tasa de excreción metabólica de uratos [4][5][6][7][8] .…”

Section: Introductionunclassified

Síndrome de la orina rosa

Carpio-Orantes¹,

Beltrán-Jiménez²

2020

RHJM

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Introducción: El síndrome de la orina rosa se caracteriza por ser una entidad clínica benigna y de curso autolimitado, a menudo sin requerir intervención terapéutica, cuya característica es la tinción de la orina de un color rosa tenue, asociada a la precipitación de cristales de ácido úrico. Tiene como factores predisponentes el uso de propofol (entre otros fármacos), así como sobrepeso/obesidad, neoplasias, cirugía, entre otras. Siendo un síndrome de baja incidencia, benigno y relacionado a cuestiones metabólicas, cáncer, cirugías y fármacos, consideramos importante su comunicación.

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Pink Urine Syndrome

Cited by 4 publications

References 0 publications

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol

Síndrome de la orina rosa

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