“Pink Urine” in Morbidly Obese Patients Following Gastric Partitioning

Deitel, Mervyn; Thompson, D.A.; Saldanha, Crysle; Ramshaw, P. J.; Patterson, Maxwell C.; Pritzker, K.P.H.

doi:10.1016/s0022-5347(17)49917-4

Cited by 8 publications

(18 citation statements)

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“…A green color can occur when a patient has taken methylene blue, amitriptyline, indomethacin, or doxorubicin 2 . Pink urine has been reported in morbidly obese patients following gastric bypass procedures or during propofol anesthesia, though this has rarely occurred 3–5 . Here, we report the first case of uric acid crystalluria‐associated pink urine in a non‐obese patient.…”

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confidence: 86%

“…Pink or red urine is an unusual occurrence that can be caused by hematuria, hemoglobinuria, propofol, 1 certain laxatives, antipsychotics such as chlorpromazine and thioridazine, chronic lead or mercury poisoning, phenolphthalein, beeturia, 6 or alkaptonuria 7 . In addition, pink urine related to uric acid crystal related has rarely been reported in morbidly obese patients following gastric bypass procedures 4,5 . A thorough review of the patient's medical history, medications, and urine analysis is helpful for physicians in making a differential diagnosis.…”

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confidence: 99%

“…Pure uric acid dihydrate crystals are colorless but can become pink when they absorb urinary pigments. Pink urine has been reported to be associated with increased urine osmolarity and decreased urine pH 4 . The mechanism of pink urine remains unclear.…”

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confidence: 99%

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Pink urine in an elderly woman

Tan

Lai

2012

Geriatrics Gerontology Int

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Pink urine in an elderly woman

Tan

Lai

2012

Geriatrics Gerontology Int

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“…This phenomenon is defined as pink urine syndrome (PUS) (Deitel et al 1984;Ogawa et al 2015b). PUS is characterized by cloudy brownish-red urine and the formation of pink sediments in urine upon centrifugation, which occurs due to uric acid (UA) precipitation resulting from urinary acidification.…”

Section: Introductionmentioning

confidence: 99%

“…PUS is characterized by cloudy brownish-red urine and the formation of pink sediments in urine upon centrifugation, which occurs due to uric acid (UA) precipitation resulting from urinary acidification. PUS is not a rare phenomenon, with a considerable number of PUS cases (4.4%) found even in healthy young populations (Ogawa et al 2015b); it is also closely linked to obesity (Deitel et al 1984;Ogawa et al 2015b). However, PUS is not a disease; instead, it appears to be a symptom that elicits some sort of physical response.…”

Section: Introductionmentioning

confidence: 99%

The Reduction in Urinary Glutamate Excretion Is Responsible for Lowering Urinary pH in Pink Urine Syndrome

Ogawa

Takiguchi

Shimizu

et al. 2016

Tohoku J. Exp. Med.

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We frequently encounter brownish-red, cloudy urine in some obese subjects, which occurs due to pink urine syndrome (PUS). PUS is a phenomenon in which uric acid precipitates into the urine due to reduced urinary pH (UpH). The mechanism underlying urinary acidification has not been elucidated so far. UpH level is adjusted by urinary excretion of ammonia synthesized from glutamate or glutamine, suggesting that renal synthesis of ammonia from glutamate or glutamine is decreased in PUS. However, this hypothesis has not been examined yet. We therefore examined the changes in the urinary excretion of these amino acids in PUS. One-hundred-fifty male students who had undergone a physical examination were enrolled. To determine the presence [PUS (+), n = 72] or absence [PUS (−), n = 78] of PUS, urinary amino acid excretion and UpH were evaluated. Independent risk factors of lower UpH were determined using multiple regression analyses. The PUS (+) subjects, who had lower UpH values than PUS (-) subjects, showed lower urinary excretion of glutamate and some other glucogenic amino acids. Thus, UpH correlated positively with the urinary excretion of glutamate in the PUS (+) subjects. A reduction in urinary glutamate but not in glutamine excretion proved to be an independent risk factor for reduced UpH. In conclusion, PUS appears to occur when a reduction in the synthesis of ammonia from glutamate causes a decrease in UpH. Our results showed that urinary glutamate excretion was reduced in PUS because renal glutamate was consumed by a reaction different from ammonia production.

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Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol

Tucker

Perazella

2019

Kidney International Reports

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Pink urine syndrome is mostly seen in patients treated with propofol anesthesia. The pink color is attributed to the presence of large concentrations of uric acid (and pigment), which is excreted in large amounts when propofol is given. We describe a case of propofol-induced pink urine syndrome and perform a comprehensive, evidence-based review. We discuss prior case studies already published in the literature as we speculate on the pathophysiology and how it translates to a clinically relevant entity.

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“Pink Urine” in Morbidly Obese Patients Following Gastric Partitioning

Cited by 8 publications

References 0 publications

Pink urine in an elderly woman

Pink urine in an elderly woman

The Reduction in Urinary Glutamate Excretion Is Responsible for Lowering Urinary pH in Pink Urine Syndrome

Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol

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