Pink Disease

Wood, Aaron; Wood, Ian

doi:10.1136/bmj.2.3898.527

Cited by 12 publications

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“…The first description of pink disease in the literature dates back to 1903 by Selter, a German physician, although cases in Australia predate this time by at least two decades (Selter 1903; Wood and Wood 1935). Pink disease remained in relative obscurity in the greater medical community until 1914, when it was again described, this time by Swift, an Australian-born physician, at an Australasian medical congress in New Zealand (Swift 1914).…”

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confidence: 99%

“…Pink disease, or infantile acrodynia as it was also known (primarily in Europe and America), was an especially prevalent condition in Australia, North America, and Central Europe in the first half of the 20th century ( Rocaz 1933 ). The first description of pink disease in the literature dates back to 1903 by Selter, a German physician, although cases in Australia predate this time by at least two decades ( Selter 1903 ; Wood and Wood 1935 ). Pink disease remained in relative obscurity in the greater medical community until 1914, when it was again described, this time by Swift, an Australian-born physician, at an Australasian medical congress in New Zealand ( Swift 1914 ).…”

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confidence: 99%

“…Case studies provided a comprehensive clinical picture of pink disease long before its etiology was established. The most commonly reported symptoms included: irritability, neurosis, photophobia (light sensitivity), hyperhidrosis (excessive sweating), hypotonia (low muscle tone), ataxia (lack of coordination), digestive problems (including loss of weight, loss of appetite, vomiting, and constipation), anemia, excessive salivation, respiratory problems, lethargy, extreme misery, slurring/lossof speech, loosening/loss of teeth, swollen extremities, and perhaps most famously (and from which the name “pink disease” was derived), marked reddening of the extremities, particularly the hands and feet ( Rocaz 1933 ; Wood and Wood 1935 ; Leys 1950 ). Fatality was reasonably high, with death resulting in 10–33% of cases ( Rocaz 1933 ).…”

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confidence: 99%

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Ancestry of Pink Disease (Infantile Acrodynia) Identified as a Risk Factor for Autism Spectrum Disorders

Shandley

Austin

2011

Journal of Toxicology and Environmental Health, Part A

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Pink disease (infantile acrodynia) was especially prevalent in the first half of the 20th century. Primarily attributed to exposure to mercury (Hg) commonly found in teething powders, the condition was developed by approximately 1 in 500 exposed children. The differential risk factor was identified as an idiosyncratic sensitivity to Hg. Autism spectrum disorders (ASD) have also been postulated to be produced by Hg. Analogous to the pink disease experience, Hg exposure is widespread yet only a fraction of exposed children develop an ASD, suggesting sensitivity to Hg may also be present in children with an ASD. The objective of this study was to test the hypothesis that individuals with a known hypersensitivity to Hg (pink disease survivors) may be more likely to have descendants with an ASD. Five hundred and twenty-two participants who had previously been diagnosed with pink disease completed a survey on the health outcomes of their descendants. The prevalence rates of ASD and a variety of other clinical conditions diagnosed in childhood (attention deficit hyperactivity disorder, epilepsy, Fragile X syndrome, and Down syndrome) were compared to well-established general population prevalence rates. The results showed the prevalence rate of ASD among the grandchildren of pink disease survivors (1 in 25) to be significantly higher than the comparable general population prevalence rate (1 in 160). The results support the hypothesis that Hg sensitivity may be a heritable/genetic risk factor for ASD.

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Ancestry of Pink Disease (Infantile Acrodynia) Identified as a Risk Factor for Autism Spectrum Disorders

Shandley

Austin

2011

Journal of Toxicology and Environmental Health, Part A

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“…Acrodynia, or "pink disease," is a condition that may be caused by an allergic reaction to parenteral mercury . [3,7,13]. Acrodynia is typically restricted to young children and infants [3,7].…”

Section: Cutaneous Manifestations Of Mercury Toxicitymentioning

confidence: 99%

“…The hands, feet, and nose may swell and turn pink in color [3,7]. A palmoplantar vesicular eruption with subsequent desquamation can also occur [13]. Additionally, a morbilliform, rubeoliform, or scarlatiniform exanthem may be seen.…”

Section: Cutaneous Manifestations Of Mercury Toxicitymentioning

confidence: 99%

Mercury toxicity presenting as acrodynia and a papulovesicular eruption in a 5-year-old girl

Lai¹,

Parsi²,

Wu³

et al. 2016

Dermatology Online Journal

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Acrodynia is a reaction that occurs in children who have been exposed to mercury. Mercury toxicity has systemic manifestations as well as cutaneous manifestations, which can appear similar to those found in a number of other diseases. We present a case of acrodynia caused by mercury exposure in a previously healthy 5-year-old girl who developed hypertension, palmoplantar pruritus, and a papulovesicular eruption. Case synopsisA 5-year-old previously healthy girl was admitted to the hospital for two months of increasing migratory joint pain, new-onset recalcitrant hypertension, irritability, photophobia, decreased appetite, and one week of intensely pruritic palmoplantar papules and vesicles. During hospitalization, her blood pressure increased to a maximum of 159/113 mm/Hg and remained on average 145/105 mm/Hg, necessitating triple anti-hypertensive therapy with amlodipine, labetalol, and hydralazine. Figure 1. Monomorphic erythematous papules and vesicles on the back (a) and hand (b). Exfoliation is beginning to occur on the distal fingers (b) and toes (c).

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Erkrankungen des vegetativen oder autonomen Nervensystems

Heinisch¹

1969

Neurologie Psychologie - Psychiatrie

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Pink Disease

Cited by 12 publications

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Ancestry of Pink Disease (Infantile Acrodynia) Identified as a Risk Factor for Autism Spectrum Disorders

Ancestry of Pink Disease (Infantile Acrodynia) Identified as a Risk Factor for Autism Spectrum Disorders

Mercury toxicity presenting as acrodynia and a papulovesicular eruption in a 5-year-old girl

Erkrankungen des vegetativen oder autonomen Nervensystems

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