Pinhal Virus, a New Arenavirus Isolated from <i>Calomys tener</i> in Brazil

Bisordi, Ivani; Levis, Silvana; Maeda, Adriana Yurika; Suzuki, Akemi; Nagasse-Sugahara, Teresa Keico; Souza, Renato Pereira de; Pereira, Luiz Eloy; Garcia, Jorge; Cerroni, Matheus de P; Silva, Franko de A e; Santos, C.; Fonseca, Benedito Antônio Lopes da

doi:10.1089/vbz.2014.1708

Cited by 12 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[7][8][9] Rodent species from the Calomys genus may be a potential reservoir of SABV, as these rodents are broadly distributed across the Brazilian territory, particularly in regions where cases of SABV have been reported (Figure 1(A)). Moreover, Calomys species have been identified as carriers of JUNV, 10 MACV, 11 Latino (LATV), 12 and Pinhal 13 viruses.…”

Section: Impact Statementmentioning

confidence: 99%

Structural and molecular biology of Sabiá virus

Bezerra,

Melo-Hanchuk,

Marques

2023

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Brazilian mammarenavirus, or Sabiá virus (SABV), is a New World (NW) arenavirus associated with fulminant hemorrhagic disease in humans and the sole biosafety level 4 microorganism ever isolated in Brazil. Since the isolation of SABV in the 1990s, studies on viral biology have been scarce, with no available countermeasures against SABV infection or disease. Here we provide a comprehensive review of SABV biology, including key aspects of SABV replication, and comparisons with related Old World and NW arenaviruses. SABV is most likely a rodent-borne virus, transmitted to humans, through exposure to urine and feces in peri-urban areas. Using protein structure prediction methods and alignments, we analyzed shared and unique features of SABV proteins (GPC, NP, Z, and L) that could be explored in search of therapeutic strategies, including repurposing intended application against arenaviruses. Highly conserved catalytic activities present in L protein could be targeted for broad-acting antiviral activity among arenaviruses, while protein-protein interactions, such as those between L and the matrix protein Z, have evolved in NW arenaviruses and should be specific to SABV. The nucleoprotein (NP) also shares targetable interaction interfaces with L and Z and exhibits exonuclease activity in the C-terminal domain, which may be involved in multiple aspects of SABV replication. Envelope glycoproteins GP1 and GP2 have been explored in the development of promising cross-reactive neutralizing antibodies and vaccines, some of which could be repurposed for SABV. GP1 remains a challenging target in SABV as evolutive pressures render it the most variable viral protein in terms of both sequence and structure, while antiviral strategies targeting the Z protein remain to be validated. In conclusion, the prediction and analysis of protein structures should revolutionize research on viruses such as SABV by facilitating the rational design of countermeasures while reducing dependence on sophisticated laboratory infrastructure for experimental validation.

show abstract

Section: Impact Statementmentioning

confidence: 99%

Structural and molecular biology of Sabiá virus

Bezerra,

Melo-Hanchuk,

Marques

2023

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…Evidence of mammarenavirus infection in rodents, bats and humans within the Americas has been previously documented in the USA, Columbia, Brazil and French Guiana [54][55][56][57][58][59][60][61][62][63][64][65]. A mammarenavirus seroprevalence rate of 2.5% was observed among wild rodents in Barbados during this study, which is comparable to seroprevalence rates observed in wild rodents from Turkey (2.4%), Italy (5.6%), the United Kingdom (5.8%) and the USA (3.1%) [66][67][68][69].…”

Section: Mammarenavirus Ifa Seropositive Rodentsmentioning

confidence: 99%

Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados

et al. 2021

View full text Add to dashboard Cite

Background: Rodents are reservoirs for several zoonotic pathogens that can cause human infectious diseases, including orthohantaviruses, mammarenaviruses and orthopoxviruses. Evidence exists for these viruses circulating among rodents and causing human infections in the Americas, but much less evidence exists for their presence in wild rodents in the Caribbean. Methods: Here, we conducted serological and molecular investigations of wild rodents in Barbados to determine the prevalence of orthohantavirus, mammarenavirus and orthopoxvirus infections, and the possible role of these rodent species as reservoirs of zoonotic pathogens. Using immunofluorescent assays (IFA), rodent sera were screened for the presence of antibodies to orthohantavirus, mammarenavirus (Lymphocytic choriomeningitis virus—LCMV) and orthopoxvirus (Cowpox virus—CPXV) infections. RT-PCR was then conducted on orthohantavirus and mammarenavirus-seropositive rodent sera and tissues, to detect the presence of viral RNA. Results: We identified antibodies against orthohantavirus, mammarenavirus, and orthopoxvirus among wild mice and rats (3.8%, 2.5% and 7.5% seropositivity rates respectively) in Barbados. No orthohantavirus or mammarenavirus viral RNA was detected from seropositive rodent sera or tissues using RT–PCR. Conclusions: Key findings of this study are the first serological evidence of orthohantavirus infections in Mus musculus and the first serological evidence of mammarenavirus and orthopoxvirus infections in Rattus norvegicus and M. musculus in the English-speaking Caribbean. Rodents may present a potential zoonotic and biosecurity risk for transmission of three human pathogens, namely orthohantaviruses, mammarenaviruses and orthopoxviruses in Barbados.

show abstract

“…Rodents are likely also reservoirs for the SABV. Recently, Bisordi et al 9 identified arenavirus sequences in 5 of 55 vesper mice (Calomys tener) that were caught in the area where the second naturally acquired infection with the SABV was identified (Espírito Santo do Pinhal, São Paulo State, Brazil); however, all sequences were different from those that had been described for the SABV. Notably, their study resulted in the identification of a new arenavirus, the Pinhal virus 9 .…”

Section: Basic Aspects Of the Sabiá Virusmentioning

confidence: 99%

“…Recently, Bisordi et al 9 performed a serological investigation among rodents that were captured in the city (Espirito Santo do Pinhal) where this case was reported to identify the host rodent species of the SABV. A total of 412 rodents of 7 different species (Necromys lasiurus, n = 164; Akodon spp., n = 116; Calomys tener, n = 68; Mus musculus, n = 55; Oligoryzomys nigripes, n = 7; Bibimys labiosus, n = 1; and Rattus rattus, n = 1) were evaluated.…”

Section: Eco-epidemiological Aspects Of Naturally Acquired Sabiá Virumentioning

confidence: 99%

Keeping track of hidden dangers - The short history of the Sabiá virus

Ellwanger

2017

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Emerging infectious diseases are a global threat. In countries like Brazil, where biodiversity is high and public health conditions in terms of infrastructure and medical care are often precarious, emerging diseases are particularly worrisome. The lack of monitoring strategies to identify pathogens with the potential to cause outbreaks or epidemics is another problem in Brazil and other developing countries. In this article, we present the history of the Sabiá virus (SABV), a pathogen that was described in the 1990s in Brazil. Several aspects of the biology and ecology of the SABV remain unknown. The SABV has the potential to cause hemorrhagic fever in humans. To date, four cases of human infections have been reported worldwide; two were naturally acquired (both in Brazil), whereas the other two were linked to occupational exposure in the laboratory environment (one in Brazil and one in the USA). In this review, we summarize the basic biological and ecological characteristics of the SABV. This is the first work to gather all available data on the historical aspects involving the cases of SABV infection along with an update on its characteristic features.

show abstract

Pinhal Virus, a New Arenavirus Isolated from Calomys tener in Brazil

Cited by 12 publications

References 15 publications

Structural and molecular biology of Sabiá virus

Structural and molecular biology of Sabiá virus

Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados

Keeping track of hidden dangers - The short history of the Sabiá virus

Contact Info

Product

Resources

About