Pineoblastoma: An electron microscopic study

Kline, Kathy T.; Damjanov, Ivan; Katz, Sheila Moriber; Schmidek, Henry H.

doi:10.1002/1097-0142(197911)44:5<1692::aid-cncr2820440524>3.0.co;2-k

Cited by 42 publications

(9 citation statements)

References 11 publications

(1 reference statement)

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“…PCs have been described as containing light and dark cells, rosettes with lumen formation, cell processes with microtubules, membrane-bound clear and dense core vesicles, fibrous bodies, vesicle-crowned rodlets, paired twisted filaments, and membranous whorls (3,6,10). PBs have been described as containing prominent perikaryon, processes rich in organelles, cilia and microvilli, granular bodies, whorls of smooth endoplasmic reticulum, and annulate lainellae (16,17). Our results are in keeping with previous reports of ultrastructural features of PCs with rosette-like structures, microtubule- containing dendritic processes, dense core granules and clear vesicles, and fibrous bodies.…”

Section: Discussionmentioning

confidence: 99%

Perispheroidal Rosettes in Irradiated Pineocytoma

Hague¹,

Post²,

Morgello³

1999

Journal of Histotechnology

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Section: Discussionmentioning

confidence: 99%

Perispheroidal Rosettes in Irradiated Pineocytoma

Hague¹,

Post²,

Morgello³

1999

Journal of Histotechnology

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“…To our knowledge, no specific work has yet addressed the relation between pineal tumors and ER stress. Only ultrastructural studies showed signs of ER enlargement in pinealoblastomas, pinealocytomas and papillary tumors (Jouvet et al, 2003;Kline et al, 1979;Tabuchi et al, 1973). However, special reference should be done about the role of melatonin in ER stress mechanisms.…”

Section: Er Stress In Primary Brain Cancersmentioning

confidence: 99%

Signaling the Unfolded Protein Response in primary brain cancers

et al. 2016

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The Unfolded Protein Response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress in the Endoplasmic Reticulum (ER). During tumor development, cancer cells are facing intrinsic (oncogene activation) and extrinsic (limiting nutrient or oxygen supply; exposure to chemotherapies) challenges, with which they must cope to survive. Primary brain tumors are relatively rare but deadly and present a significant challenge in the determination of risk factors in the population. These tumors are inherently difficult to cure because of their protected location in the brain. As such surgery, radiation and chemotherapy options carry potentially lasting patient morbidity and incomplete tumor cure. Some of these tumors, such as glioblastoma, were reported to present features of ER stress and to depend on UPR activation to sustain growth, but to date there is no clear general representation of the ER stress status in primary brain tumors. In this review, we describe the key molecular mechanisms controlling the UPR and their implication in cancers. Then we extensively review the literature reporting the status of ER stress in various primary brain tumors and discuss the potential impact of such observation on patient stratification and on the possibility of developing appropriate targeted therapies using the UPR as therapeutic target.

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“…Cell processes Histopathology of tumors of the pineal region Review future science group and cell junctions are rarely seen. Rudimentary organelles, scarce dense core granules and, occasionally, cilia can be present [11,45,55,58,78].…”

Section: Ultrastructurementioning

confidence: 99%

Histopathology of Tumors of the Pineal Region

et al. 2010

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Pineal region tumors are heterogeneous lesions and include mainly pineal parenchymal tumors (PPTs), papillary tumors of the pineal region (PTPRs) and germ cell tumors (GCTs). This article describes the cystic pineal gland compared with normal tissue and histopathological features of the most frequent pineal region tumors. PPTs are subdivided into pineocytoma (grade I), pineoblastoma (grade IV) and tumors with intermediate differentiation (PPTIDs; grades II-III). A grading system based on the number of mitoses and neurofilament protein expression distinguishes low- from high-grade PPTID. PTPR is a new tumoral entity thought to originate from the subcommissural organ. GCTs include germinoma, embryonal carcinoma, teratoma, yolk sac tumor and choriocarcinoma and are often of mixed histologic composition. New histogenetic data for GCTs are presented.

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Pineoblastoma: An electron microscopic study

Cited by 42 publications

References 11 publications

Perispheroidal Rosettes in Irradiated Pineocytoma

Perispheroidal Rosettes in Irradiated Pineocytoma

Signaling the Unfolded Protein Response in primary brain cancers

Histopathology of Tumors of the Pineal Region

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