Pineal Tumors and Ectopic Pinealomas

Bradfield, John S.; Pérez, Carlos A.

doi:10.1148/103.2.399

Cited by 81 publications

(15 citation statements)

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“…The results of radiotherapy of germinoma cases (many of them without biopsy) reported by various authors [3,5,10,16,26,28,30. 31] were at least not better than our results.…”

Section: Radiotherapy Without Direct Surgery or Direct Surgery With Rmentioning

confidence: 99%

“…In the literature [3,5,10,16,28], the incidence of dissemination méta stasés of germinoma in the cerebrospinal fluid space was from 8 to 20%. In our series this was 5%.…”

Section: Radiotherapy Without Direct Surgery or Direct Surgery With Rmentioning

confidence: 99%

“…There have been many reports as to the effectiveness of radiotherapy and the follow-up results [3,5,10,16,26,28,30,31], In most of these reports, however, histological verification of the tumor is almost lacking or insufficient. For example, in the most recent report of Ueki and Tanaka [29] of 88 cases of tumors in the pineal region (the report included, besides these 88 cases, 22 cases of germinoma of other locations), probably the largest series so far published, they ana lysed the follow-up results of 61 cases of germinoma, among which only 20 cases were histologically verified and 41 cases were diagnosed as germinoma 'only clinically by cerebrospinal fluid cytology, computerized tomography (CT), or by recognition of prompt and distinct response to radiotherapy in ventriculography or CT'.…”

Section: Introductionmentioning

confidence: 99%

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Pinealoma (Germinoma) Treated by Direct Surgery and Postoperative Irradiation

Sano

Matsutani²

1981

Pediatr Neurosurg

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60 cases of histologically verified pinealoma of the two-cell-pattern type (the so-called germinoma) experienced from 1962 to 1979 were submitted to direct surgery (by occipital transtentorial approach or infratentorial supracerebellar approach in case of tumors in the pineal region and subfrontal approach in cases of suprasellar tumors) and postoperative irradiation. Locations of tumors were 32 in the pineal region, 20 in the suprasellar region, and 8 in other areas. There was no operative mortality. The postoperative survival rates (the observed survival rates) of these cases were as follows: the 1-year survival rate (1 YSR) was 94.8%, the 5-year survival rate (5 YSR) was 74.8% and 10-year survival rate (10 YSR) was 69.3%. As for pinealomas in the pineal region, 1 YSR was 93.5%, 5 YSR was 64.7% and 10 YSR was 60.1 %; for tumors in the suprasellar region, 1 YSR was 100%, 5 YSR was 100% and 10 YSR was 92.3%. In cases aged from 15 years up, 1 YSR was 93.7%, 5 YSR was 65.0% and 10 YSR was 60.2%, and in cases under 15 years (children), 1 YSR was 95.1%, 5 YSR was 86.9% and 10 YSR was 86.9%. Thus, the results were much better in suprasellar germinoma cases than in pineal cases and in children than in adolescents and adults. Suprasellar germinoma cases under 15 years showed 100%in 1 YSR, 5 YSR and 10 YSR. The reason for this is probably that surgical removal of tumors or reduction of the bulk of tumors may be easier or more extensive in suprasellar germinomas than in pineal germinomas. Among these 60 cases, 2 died of recurrence of tumor, 3 died of dissemination metastases in the cerebrospinal fluid space and the other 11 died of other diseases or due to unknown cause. Besides these 60 cases, 10 cases of probable pinealomas (germinomas) were treated by irradiation without direct surgery. Among these, 1 case died 3 years and 1 month later and 1 case had recurrence and was irradiated again. Most of these cases were experienced in the past 2 years and the follow-up was not long enough. All these cases had rather small tumors, single or multiple. The histogenesis of the tumor and the causes of its radiosensitivity are discussed.

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“…The results of radiotherapy of germinoma cases (many of them without biopsy) reported by various authors [3,5,10,16,26,28,30. 31] were at least not better than our results.…”

Section: Radiotherapy Without Direct Surgery or Direct Surgery With Rmentioning

confidence: 99%

“…In the literature [3,5,10,16,28], the incidence of dissemination méta stasés of germinoma in the cerebrospinal fluid space was from 8 to 20%. In our series this was 5%.…”

Section: Radiotherapy Without Direct Surgery or Direct Surgery With Rmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pinealoma (Germinoma) Treated by Direct Surgery and Postoperative Irradiation

Sano

Matsutani²

1981

Pediatr Neurosurg

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“…The tumors of the pineal region are uncommon, ranging from 0.5 to 2% of all intracranial neoplasms in several review papers 3,5,6,14 . The origin of the tumors of this region can be the pineal gland itself, the posterior portion of the third ventricle and the quadrigemina cistern.…”

Section: Discussionmentioning

confidence: 99%

“…Edema, hemorrhage and contrast enhancement are common features. Nonneoplastic processes that may also simulate a pineal tumor at this location include epidermoid, dermoid and glial cysts 3,4,7,14 .…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma multiforme of the pineal region: case report

Gasparetto

Warszawiak

Adam

et al. 2003

Arq. Neuro-Psiquiatr.

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-Purpose: pineal region tumors are uncommon, and comprise more frequently three categories: germ cell, parenchymal cell and glial tumors. Most pineal gliomas are low-grade astrocytomas. Glioblastoma multiforme, the most aggressive and common brain tumor, is extremely rare at this location with only few cases reported. Case description: a 29-year-old woman with a two month history of headache, nuchal pain, fever, nausea and seizures and physical examination showing nuchal rigidity, generalized hypotony, hypotrophy and hyper-reflexia, Babinski sign and left VI cranial par palsy. CT scan examination revealed a ill-defined hypodense lesion at the pineal region with heterogeneous contrast enhancement. MRI showed a lesion at the pineal region infiltrating the right thalamic region. The patient underwent a right craniotomy with partial resection of the mass. The histological examination of paraffin-embedded material defined the diagnosis of glioblastoma multiforme. Post-operative radiotherapy was indicated but the patient refused the treatment and died two months afterwards. Conclusion: in spite of its rarity at this location, glioblastoma multiforme should be considered in the differential diagnosis of aggressive lesions at the pineal region.KEY WORDS: brain tumor, pineal gland, glioblastoma multiforme.Glioblastoma multiforme de região pineal: relato de caso Glioblastoma multiforme de região pineal: relato de caso Glioblastoma multiforme de região pineal: relato de caso Glioblastoma multiforme de região pineal: relato de caso Glioblastoma multiforme de região pineal: relato de caso RESUMO -Objetivo: Os tumores da região pineal são incomuns e podem ser divididos em três categorias de acordo com a sua origem: células germinativas, células do parênquima e células gliais. Em sua maioria, os gliomas de pineal são astrocitomas de baixo grau, sendo que o seu correspondente maligno, glioblastoma multiforme, é o mais comum e agressivo tumor encefálico e é extremamente raro nesta localização, com apenas alguns casos relatados na literatura. Caso: Mulher com 29 anos apresentando há 2 meses cefaléia, nucalgia, febre, náuseas e crises convulsivas. O exame físico mostrou rigidez de nuca, hipotonia, hipotrofia e hiperreflexia generalizadas, sinal de Babinski e paralisia do VI nervo craniano. A tomografia computadorizada revelou lesão hipodensa mal delimitada na topografia de pineal, com captação heterogênea de contraste. A ressonância magnética demonstrou lesão na região pineal com infiltração de tálamo à direita. A paciente foi submetida a craniotomia direita com ressecção parcial do tumor. O exame histológico definiu o diagnóstico de glioblastoma multiforme. No pós-operatório foi indicada radioterapia, mas a paciente recusou o tratamento e morreu dois meses depois. Conclusão: Apesar de raro nesta topografia, os glioblastomas multiformes devem ser considerados no diagnóstico diferencial de lesões agressivas localizadas na glândula pineal. PALAVRAS-CHAVE: tumor encefálico, glândula pineal, glioblastoma multiforme.

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Pineal Tumors

Donat¹

1978

Arch Neurol

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Pineal Tumors and Ectopic Pinealomas

Cited by 81 publications

References 1 publication

Pinealoma (Germinoma) Treated by Direct Surgery and Postoperative Irradiation

Pinealoma (Germinoma) Treated by Direct Surgery and Postoperative Irradiation

Glioblastoma multiforme of the pineal region: case report

Pineal Tumors

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