Pineal Region Gliomas: A Systematic Review of Clinical Features and Treatment Outcomes

Abstract

Background/Aim: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes. Materials and Methods: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. Results: Twelve studies describing 81 patients were included. The median age was 39 years (male=54.3%). Fifty patients (61.7%) had obstructive hydrocephalus requiring cerebrospinal fluid diversion with either ventriculoperitoneal shunt (VPS) (40.0%) or endoscopic third ventriculostomy (ETV) (24.0%). Patients who underwent VPS had significant survival benefits compared to ETV (p<0.05). All patients in our review underwent surgery, and gross-total resection (≥98%) was achieved in 34.6%. The supracerebellar infratentorial approach was the most employed surgical approach (62.3%). Chemotherapy was administered in 32.1% of cases, and radiotherapy in 40.7%. The median overall survival (OS) was 12 months, and the overall one-year survival rate was 60%. Conclusion: This study could not establish a correlation between the extent of tumor resection and positive treatment outcomes. However, among cases with hydrocephalus, patients who underwent VPS placement had better survival as compared to ETV.

[Retracted] Value of CSF‐Cl, CSF‐GS, CSF‐MALB, and CSF‐ADA in Differential Diagnosis of Secondary Hydrocephalus

“…It often has the characteristics of acute onset, rapid progress, many complications, and high disability rate [ 1 ]. If the treatment is not timely, it may lead to lifelong disability, leaving irreversible damage, and even endanger the life and health of patients [ 2 , 3 ]. Hemorrhagic hydrocephalus and neoplastic hydrocephalus are two common types of secondary hydrocephalus [ 3 , 4 ].…”

Gliomas Infiltrating the Corpus Callosum: A Systematic Review of the Literature

“…Historically, G-I-CC were deemed "inoperable" owing to the potentially severe postresection complications, with early series preferring diagnostic biopsy to establish palliative care [21,61,65]. The advent of superior imaging techniques and intraoperative adjuncts, coupled with better knowledge of brain connectomics, has increased the surgical inclination toward G-I-CC resection, similarly to other gliomas [37,71,78,79]. Given its known association with improved survival, maximally safe tumor resection, when feasible, also represents the primary treatment for G-I-CC, further enabling patients to complete postsurgery radiation and chemotherapy protocols [34].…”