Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas

Goncharova, N. D.; Vengerin, A. A.; Khavinson, V. Kh.; Лапин, Б. А.

doi:10.1016/j.exger.2004.10.004

Cited by 18 publications

(13 citation statements)

References 22 publications

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“…Taking into consideration the encouraging data testifying to high geroprotective activity of both natural tissue specific and synthetic peptide preparations we have been concentrating our attention on studies of geroprotective activity of peptides in old and senile people in recent years (Khavinson 2002;Khavinson and Morozov 2003;Labunets et al 2004a, b;Korkushko et al 2004;Anisimov and Khavinson 2005;Khavinson and Malinin 2005;Goncharova et al 2005;Kozina et al 2007). Thus, annual treatment course with thymus and pineal preparations led to a reliable decrease in mortality (Table 3), to improvement of brain function and that of immune, endocrine, cardio-vascular systems, increased density of osseous tissue (Khavinson 2002;Khavinson and Morozov 2003;Labunets et al 2004a, b;Korkushko et al 2004).…”

Section: Effect Of the Peptide Bioregulators In Humanmentioning

confidence: 97%

Peptide bioregulation of aging: results and prospects

2009

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The review comprises the results of author's long-term investigation in the mechanisms of aging and a role of peptide bioregulators in prevention of age-related pathology. A number of small peptides have been isolated from different organs and tissues and their analogues (di-, tri-, tetrapeptides) were synthesized from the amino acids. It was shown that long-term treatment with some peptide preparations increased mean life span by 20-40%, slow down the age-related changes in the biomarkers of aging and suppressed development of spontaneous and induced by chemical or radiation carcinogens tumorigenesis in rodents. Possible mechanisms of the biological effects of small peptides are discussed in the paper. The results of clinical applications of peptide preparation during the period of 6-12 years are presented as well.

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Section: Effect Of the Peptide Bioregulators In Humanmentioning

confidence: 97%

Peptide bioregulation of aging: results and prospects

2009

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“…The same old monkeys revealed a restoration to normal indices of a daily rhythm of secretion of the main hormone of adrenal glandcortisol. Administration of the peptide or pineal preparation to old animals led also to restoration of disturbed with ageing glucose tolerance (Goncharova et al 2005;Khavinson et al 2001).…”

Section: Peptidergic Regulation Of Ageingmentioning

confidence: 96%

Biogerontology in Russia: from past to future

2010

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The paper presents major steps of gerontology development in Russia. The issues of training in gerontology and geriatrics, institutional infrastructure within the Gerontological Society of the Russian Academy of Sciences and its activities have been considered therein. Some results of Russian researchers obtained during 2005-2010 have been summarized as well. Special attention is given to the prospects of gerontology in Russia.

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“…The stimulatory effects of pineal hormones on melatonin production have been proven in rats [6], old primates [1,7], and elderly humans [2]. In addition, numerous experimental studies have shown that peptide preparations fromn the pineal gland inhibit age-associated changes in the mechanisms of neuroendocrine regulation and reproductive function, correct disorders of carbohydrate and lipid metabolism, improve the immune and antioxidant status, and exhibit clear-cut oncostatic and geroprotective effects [1,4,[7][8][9]. On the other hand, the effi ciency of long-term use of peptide preparations from the pineal gland in rapidly aging elderly patients is a very interesting problem.…”

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confidence: 99%

Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-Up

et al. 2011

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The paper presents the results of randomized comparative study of the efficiency of peptide geroprotector from the pituitary gland in elderly patients with rapidly aging cardiovascular system. Over three years 39 coronary patients received, in addition to basic therapy, regular courses of epithalamin (peptide drug), while 40 coronary patients (control group) received basic therapy alone. Long-term treatment with epithalamin (6 courses over 3 years) decelerated aging of the cardiovascular system, prevented age-associated impairment of physical endurance, normalized circadian rhythm of melatonin production and carbohydrate and lipid metabolism. A significantly lower mortality in the group of patients treated with epithalamin in parallel with basic therapy also indicated a geroprotective effect of the peptide preparation from the pineal gland.

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Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas

Cited by 18 publications

References 22 publications

Peptide bioregulation of aging: results and prospects

Peptide bioregulation of aging: results and prospects

Biogerontology in Russia: from past to future

Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-Up

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