Pineal-Hypothalamic Interactions: Possible Role of the Monoaminergic Neuron System

Mess, B; Trentini, G. P.; Rúzsás, C; Gaetani, C. F. De

doi:10.1007/978-1-4757-1451-7_20

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Although species-and age-related peculiarities, diurnal or seasonal alterations of illumination in the given experiment, as well as the doses of melatonin used and pathways of its injections, were noticeably reflected on the data of examination of the above aspects of the effects of exogenous melatonin, the data obtained allowed researchers to qualify the epiphysis and its main hormone melatonin as factors responsible for inhibition of thyroid activity. Findings obtained in the corresponding studies were reported in a number of reviews [11,30].…”

Section: Introductionmentioning

confidence: 50%

Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

2008

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The authors of this review generalize and analyze the published data, as well as their own findings, related to melatonin-mediated interaction of the pineal gland (the brain epiphysis) with the hypothalamo-hypophysealthyroid axis (HHTA). The review deals with (i) historical aspect of development of the concepts on neuroendocrine mechanisms underlying the control of functions of the thyroid gland, (ii) data on circadian and seasonal rhythms of the functioning of the epiphysis and HHTA, (iii) basic facts about direct and feedback connections between the brain epiphysis and HHTA, and (iv) overview of the experimental data on age-related changes in the epiphysis-thyroid axis.

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Section: Introductionmentioning

confidence: 50%

Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

2008

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“…Alternatively, differences be tween the two strains may exist in pineal secretion rates of melatonin, its pharmacokinetics and tissue distribution, and/or its metabolic clearance rate leading to eventually similar levels of circulating melatonin. However, serum levels of melatonin do not necessarily reflect cerebral lev els of this neurohormone [32,33].…”

Section: Discussionmentioning

confidence: 99%

Differences in Arylalkylamine N-Acetyltransferase Activity between Inflammatory Disease-Susceptible Lewis and -Resistant Fischer Rats

Mastorakos

Patchev²,

Chader³

et al. 1995

Neuroendocrinology

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Lewis (LEW/N) and Fischer (F344/N) rats are histocompatible inbred strains characterized, respectively, by susceptibility and resistance to inflammatory disease. The susceptibility of LEW/N rats to inflammation has been associated with deficient corticotropin-releasing hormone (CRH), ACTH, and corticosterone responses to inflammatory stimuli, specifically attributed to a global impairment in hypothalamic CRH neuron function. In contrast to the LEW/N rats, F344/N rats demonstrate an intact hypothalamic-pituitary-adrenal (HPA) axis. Melatonin, a neurohormone initially isolated in the pineal gland, has been implicated with inhibition of the HPA axis. To investigate melatonin synthesis and secretion in LEW/N and F344/N rats, we examined the diurnal activity of pineal arylalkylamine N-acetyltransferase (NATl), the rate-limiting enzyme in melatonin biosynthesis, which demonstrates circadian rhythmicity, as well as the diurnal levels of serum melatonin, in both strains. Arylamine N-acetyltransferase (NAT2), a related enzyme activity, thought not to be regulated in a circadian manner, was examined as a control of NATl activity. Pineal NATl activity peak was observed later and reached significantly higher levels in LEW/N than in F344/N rats. Serum melatonin levels reflected the circadian pattern of the NATl activity, without, however, showing any quantitative differences between the two strains. Time-course of pineal NATl activity response to β-adrenergic stimulation was parallel in the two rat strains, whereas the magnitude of the response was greater in LEW/N than in F344/N rats. No circadian or major quantitative differences in NAT2 activity were found between the two strains. Size-exclusion HPLC chromatograms of NATl activity revealed similar patterns in both rat strains. These findings demonstrate a difference in the circadian and β-adrenergic-stimulated regulation of melatonin synthesis in the two rat strains.

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Pineal-Hypothalamic Interactions: Possible Role of the Monoaminergic Neuron System

Cited by 2 publications

References 37 publications

Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

Differences in Arylalkylamine N-Acetyltransferase Activity between Inflammatory Disease-Susceptible Lewis and -Resistant Fischer Rats

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