Pineal gliosarcoma in a 5-year-old girl

Granados, Ana; Ospina, Camila; Paredes, Stephania

doi:10.1016/j.radcr.2017.11.003

Cited by 5 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A case of pediatric gliosarcoma associated with NF1 was recently reported by Dogan et al [33]. Granados et al reported a pineal gliosarcoma in a five-year-old girl, the first reported case in this unusual location [29]. Various studies have emphasized the importance of gross total resection in achieving relatively better prognosis [23,32].…”

Section: Discussionmentioning

confidence: 99%

Gliosarcoma in patients under 20 years of age. A clinicopathologic study of 11 cases and detailed review of the literature

et al. 2021

View full text Add to dashboard Cite

Background Gliosarcoma is a rare variant of IDH- wild type glioblastoma with both glial and mesenchymal differentiation. It accounts for approximately 2% of glioblastomas and has a poor prognosis similar to that of classic glioblastoma. It is seen mostly between 40 and 60 years of age with a mean age over 50 years. Pediatric gliosarcoma is even rarer than gliosarcoma in adults. We describe the clinicopathological features of gliosarcoma in patients under 20 years of age and determine whether there are significant differences from gliosarcoma in adults. We also present detailed review of published literature on pediatric gliosarcoma. Methods Slides of gliosarcomas in patients under 20 years of age were reviewed. Clinicopathological features were noted in detail and follow up was obtained. Results Eleven cases of gliosarcoma were reported in patients under 20 years of age. Ages ranged from three to 19 years (mean age 13 years). Frontal, parietal and temporal lobes were the commonest locations. Mean and median tumor size was six and five cm respectively. All 11 cases demonstrated the classic biphasic pattern. In 10 cases, glial component was astrocytic and was highlighted on GFAP. Sarcomatous component in most cases resembled fibrosarcoma and was high grade in 72.7%. Glial areas were reticulin poor while sarcomatous areas were reticulin rich. In over 45% cases, bizarre tumor giant cells were seen in the sarcomatous areas. In 1 case, sarcomatous areas showed extensive bone and cartilage formation. Other histologic features included hyalinized blood vessels, hemorrhage, infarction, gemistocytic cells, rhabdoid cells etc. Follow up was available in nine patients, five received chemoradiation post resection while three received radiotherapy only. Prognosis was dismal and eight patients died within one to 14 months following resection. Conclusions Gliosarcomas in patients under 20 comprised 13% of all gliosarcomas reported during the study period. Frequency and mean age were higher compared to other published reports. Pathological features were similar to those described in literature. Clinicopathological features and prognosis of pediatric gliosarcomas were similar to adult gliosarcomas.

show abstract

Section: Discussionmentioning

confidence: 99%

Gliosarcoma in patients under 20 years of age. A clinicopathologic study of 11 cases and detailed review of the literature

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The PG has been described as a small, odd, endocrine organ located in the roof of the midbrain, above the superior colliculi and behind the third ventricle (16). It is joined to the habenular and posterior commissures by means of the pineal stalk, whose body is bathed by cerebrospinal fluid and covered by pia mater, the pia mater in turn becomes a capsule that provides the gland with partitions that in turn allow its irrigation (17).…”

Section: Morphological Structurementioning

confidence: 99%

“…On the other hand, its irrigation, unlike others in the body, is considered of a high flow considering that it is a small organ, in addition to the fact that the blood vessels that integrate it lack a blood-brain barrier (13,16). In addition, a study by Macchi & Bruce identified that the PG reached a blood flow that equaled the neurohypophysis in rats and was exceeded only by the flow from the kidneys (12,13).…”

Section: Morphological Structurementioning

confidence: 99%

Recent descriptions on physiological concepts of the pineal gland: what's new?

Hoz¹,

Viracacha-López²,

Sarmiento-Palma³

et al. 2021

roneuro

View full text Add to dashboard Cite

The pineal gland is an endocrine organ located in the cranial vault. Its endocrine function has been extensively studied and has been found to be the cause of important regulatory functions in the physiology of the human body. Although the initial approaches to the suggestive action of this organ on the organism were of a philosophical and spiritual nature, in the last century technological advances have made it possible to clearly elucidate its effector function as an endocrine gland. In this order of ideas, the objective of this review is to address basic and recent descriptions of the physiology of the pineal gland.

show abstract

Tumors of Glial Origin

Florian

Tronciu

2020

Pineal Region Lesions

View full text Add to dashboard Cite

Pineal gliosarcoma in a 5-year-old girl

Cited by 5 publications

References 9 publications

Gliosarcoma in patients under 20 years of age. A clinicopathologic study of 11 cases and detailed review of the literature

Gliosarcoma in patients under 20 years of age. A clinicopathologic study of 11 cases and detailed review of the literature

Recent descriptions on physiological concepts of the pineal gland: what's new?

Tumors of Glial Origin

Contact Info

Product

Resources

About