Pineal Gland Lymphoma: Case Report and Literature Review

Gupta, Akshya; Johnson, Mahlon D.; Hussain, Ali

doi:10.4103/2156-7514.166350

Cited by 5 publications

(7 citation statements)

References 7 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The frontal and parietal lobes are the most commonly involved sites followed by the periventricular region, corpus callosum, basal ganglia, and cerebellum. [ 3 , 5 ] Few have reported PCNSL infiltration of the suprasellar[ 11 ] or pineal[ 6 ] regions making simultaneous involvement an exceptionally unusual and, to the authors’ knowledge, a previously unreported finding. One case of nodal non-Hodgkin lymphoma metastasizing to both the suprasellar and pineal regions has previously been described.…”

Section: Discussionmentioning

confidence: 98%

Neurolymphomatosis of the brachial plexus from atypical primary central nervous system lymphoma lesions: A case report and review of the literature

Kizek

Goethe

Karas

et al. 2022

Surgical Neurology International

View full text Add to dashboard Cite

Background: Primary central nervous system lymphoma (PCNSL) is an aggressive and extranodal non-Hodgkin lymphoma limited to the neuroaxis. In immunocompetent individuals, PCNSL is more common in older adults and lacks the association with the Epstein–Barr virus found in individuals with AIDS-associated PCNSL. Because the clinical presentation and radiographic findings of PCNSL are highly variable, stereotactic brain biopsy is typically required for definitive diagnosis. High-dose methotrexate, in combination with other chemotherapeutic agents with or without whole brain radiation, is the mainstay of treatment. Case Description: A 70-year-old HIV-negative woman presented with confusion, acute flaccid left arm weakness, and left hand numbness. Head computed tomography without contrast demonstrated a 1 cm hyperdense round lesion in the suprasellar cistern that prompted further evaluation. Gadolinium-enhanced brain magnetic resonance imaging demonstrated enhancing lesions with heterogeneous signal intensity in the suprasellar, pineal, and right periatrial regions that did not explain the limb weakness and numbness. Serum and cerebrospinal fluid (CSF) studies were unrevealing, and a diagnosis of PCNSL was made following stereotactic biopsy. The patient’s liver cirrhosis precluded chemotherapy, but treatment with whole-brain radiation was pursued. Conclusion: The myriad clinical presentations and insidious course of PCNSL contribute to diagnostic difficulties, delays in treatment, and poor outcomes. Stereotactic brain biopsy is the primary method of PCNSL diagnosis since malignant cells are typically not detected in CSF. PCNSL should be considered in the differential diagnosis when immunocompetent elderly patients present with multiple intracranial lesions, even in the presence of lower motor neuron findings.

show abstract

Section: Discussionmentioning

confidence: 98%

Neurolymphomatosis of the brachial plexus from atypical primary central nervous system lymphoma lesions: A case report and review of the literature

Kizek

Goethe

Karas

et al. 2022

Surgical Neurology International

View full text Add to dashboard Cite

show abstract

“…Kim et al reviewed reported cases of primary and secondary pineal lymphoma in 2016 and found 10 cases, of whom 2 were secondary, with 1 retroperitoneal primary and 1 gastric primary (10). Since then, two additional cases of pineal lymphoma have been reported, one presenting with masses in the adrenal gland, the other one presenting as primary pineal lymphoma (11,12). When we look at the literature, pineal gland metastases are observed less frequently.…”

Section: Discussionmentioning

confidence: 99%

Pineal Metastazların Manyetik Rezonans Görüntüleme Bulguları

Aydın

Şaylısoy

Yıldız

2022

Osmangazi̇ Journal of Medicine

View full text Add to dashboard Cite

Pineal bez metastazları oldukça nadirdir. Çalışmamızın amacı, pineal bez metastazlarının manyetik rezonans görüntüleme bulgularını değerlendirmektir. Bu çalışmada Eylül 2010 ile Aralık 2019 tarihleri arasında hastane/ radyoloji arşivindeki beyin manyetik rezonans görüntülemelerinin raporları retrospektif olarak tarandı. Olgular belirlendikten sonra, hastaların cinsiyet, yaş, tanı, sağkalım süresi gibi özellikleri ve boyut (en büyük kesit çap), T1 ağırlıklı, T2 ağırlıklı sinyaller, kontrast tutulumu, ek beyin metastatik tutulum alanları gibi özellikler değerlendirildi. Araştırmamızda pineal metastazlı 7 hasta tespit edildi. Altta yatan maligniteler akciğer (N 2), meme (N 2), prostat kanseri (N 1), nöroblastom (N 1), non-Hodgkin lenfoma (N 1) idi. Pineal metastaz saptandıktan sonra ortalama yaşam süresi 3.14 aydı. Lezyonların boyutları 0.8 ile 1.8 cm arasında değişiyordu. Altı tümör, hem T1 ağırlıklı hem de T2 ağırlıklı olarak gri cevhere göre izointens idi. Biri T1 ağırlıklı ve T2 ağırlıklı görüntülerde heterojen sinyal intensitesi gösterdi. 7 tümörden 6'sı homojen solid kontrastlanma gösterirken, bir tümör nekroza bağlı heterojen kontrastlanma gösterdi. İki hastada leptomeningeal, bir hastada hipofiz sapı, bir hastada parankim, bir hastada kalvaryum-dural metastaz vardı. Kalan 3 hastada ise beyinde eşlik eden metastaz izlenmedi. Bilinen malignitesi olan hastalarda pineal lezyonların varlığı metastatik tutulum şüphesini artırmalıdır.

show abstract

“…These include several acute symptoms, such as increased intracranial pressure syndrome from obstruction of the aqueduct of Sylvius and consequent hydrocephalus, and Parinaud syndrome. Parinaud syndrome is caused by the compression or invasion of the tectal plate and is characterized by supranuclear vertical gaze disturbance (often manifesting with diplopia), mydriasis, failed ocular convergence, and blepharospasm (52)(53)(54). As a result of increased intracranial pressure patients also present headache, nausea, and vomiting.…”

Section: Signs and Symptoms Of Pineal Gland Pathologymentioning

confidence: 99%

“…CNS lymphoma rarely involves the pineal gland, and few cases are reported in the literature (53). Headache is one of the most common presenting symptoms in these patients, although acute symptoms such as focal neurologic deficits, fever, diplopia, altered mental status, and seizure are also described.…”

Section: Pineal Cystsmentioning

confidence: 99%

See 1 more Smart Citation

Neuroimaging in emergency: a review of possible role of pineal gland disease

et al. 2019

View full text Add to dashboard Cite

The pineal gland can be involved in a variety of neoplastic and congenital masses and tumors. Pineal gland neoplasms occur more frequently in children, accounting for 3-8% of intracranial tumors in the pediatric population. Pineal cysts are small lesions usually asymptomatic and encountered incidentally.Pathologic processes involving the pineal region produce signs and symptoms related to the mass effect on the adjacent structures and invasion of surrounding structures. These include several acute symptoms, such as increased intracranial pressure syndrome from obstruction of the aqueduct and consequent hydrocephalus, and Parinaud syndrome. Pineal apoplexy is rare and refers to the sudden neurological deterioration following hemorrhage in the pineal gland, most commonly into a pineal cyst. Knowledge of the clinical presentation and imaging features of these lesions is essential to narrow the differential diagnosis, especially when presenting with acute onset.

show abstract

Pineal Gland Lymphoma: Case Report and Literature Review

Cited by 5 publications

References 7 publications

Neurolymphomatosis of the brachial plexus from atypical primary central nervous system lymphoma lesions: A case report and review of the literature

Neurolymphomatosis of the brachial plexus from atypical primary central nervous system lymphoma lesions: A case report and review of the literature

Pineal Metastazların Manyetik Rezonans Görüntüleme Bulguları

Neuroimaging in emergency: a review of possible role of pineal gland disease

Contact Info

Product

Resources

About