Pineal Cyst Simulating Pinealoblastoma in 11 Children With Retinoblastoma

Karatza, Ekaterini C.

doi:10.1001/archopht.124.4.595

Cited by 17 publications

(6 citation statements)

References 5 publications

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“…Pineal cysts in retinoblastoma patients have a reported incidence ranging between 5 and 37%, with some authors indicating an association with hereditary disease (Beck Popovic et al, 2006;Ruiz Del Rio et al, 2014), whereas others do not (Ramasubramanian et al, 2013). They are comparable in size with cysts in age-matched healthy controls (Pham et al, 2015), and do not progress to a tumor (Barboriak et al, 2001;Beck Popovic et al, 2006;Karatza et al, 2006;Ramasubramanian et al, 2013).…”

Section: Differential Diagnosis: Pineal Cystsmentioning

confidence: 99%

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Munier

Beck‐Popovic

Chantada

et al. 2019

Progress in Retinal and Eye Research

160

157

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Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by the first eye salvage attempts with radiotherapy. This led to the empiric delineation of a window for conservative management subject to a "state of metastatic grace" never to be violated. Over the last two decades, conservative management of retinoblastoma witnessed an impressive acceleration of improvements, culminating in two major paradigm shifts in therapeutic strategy. Firstly, the introduction of systemic chemotherapy and focal treatments in the late 1990s enabled radiotherapy to be progressively abandoned. Around 10 years later, the advent of chemotherapy in situ, with the capitalization of new routes of targeted drug delivery, namely intra-arterial, intravitreal and now intracameral injections, allowed significant increase in eye preservation rate, definitive eradication of radiotherapy and reduction of systemic chemotherapy. Here we intend to review the relevant knowledge susceptible to improve the conservative management of retinoblastoma in compliance with the "state of metastatic grace", with particular attention to (i) reviewing how new imaging modalities impact the frontiers of conservative management, (ii) dissecting retinoblastoma genesis, growth patterns, and intraocular routes of tumor propagation, (iii) assessing major therapeutic changes and trends, (iv) proposing a classification of relapsing retinoblastoma, (v) examining treatable/preventable disease-related or treatment-induced complications, and (vi) appraising new therapeutic targets and concepts, as well as liquid biopsy potentiality.

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Section: Differential Diagnosis: Pineal Cystsmentioning

confidence: 99%

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Munier

Beck‐Popovic

Chantada

et al. 2019

Progress in Retinal and Eye Research

160

157

View full text Add to dashboard Cite

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“…It was anticipated that about 5-15 of these patients should have manifested pinealoblastoma, but the chemotherapy may have prevented the development of the condition. It should be noted that benign pineal cyst can simulate pinealoblastoma and can best be differentiated using high-resolution magnetic resonance imaging (MRI) [12]. Pineal cysts require no treatment and should not be confused with pinealoblastoma.…”

Section: Let's Review the Terminology For Retinoblastomamentioning

confidence: 99%

Basic understanding of current classification and management of retinoblastoma

Jones

Rhee

2006

Current Opinion in Ophthalmology

398

201

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It is essential that the clinician understand the specific strengths and weaknesses of each technique so that only good quality retinal nerve fiber layer information will be used in conjunction with careful clinical examination and visual function testing for glaucoma management decisions. Longitudinal studies are needed to evaluate the ability of these instruments to document retinal nerve fiber layer change over time.

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“…This finding can cause confusion in the diagnosis of pineoblastoma, and it could have been erroneously diagnosed as a pineal cyst, with severe clinical consequences. 8 This has been reported only once before. Sugiyama et al 26 reported a case of a pineoblastoma with a large central cyst, histopathologically due to central necrosis.…”

Section: Discussionmentioning

confidence: 88%

“…The combination of retinoblastoma, suprasellar tumor, and pineal cystis is also reported, which, according to Popovic et al, 7 further adds to a possible relationship between hereditary retinoblastoma and pineal lesions. Karatza et al 8 reported 11 patients with retinoblastoma with pineal cysts simulating pineoblastoma. They recommended that clinicians should be aware of the presence of this benign lesion when performing routine neuroimaging, especially in patients with bilateral disease.…”

mentioning

confidence: 99%

Brain Abnormalities on MR Imaging in Patients with Retinoblastoma

Rodjan

Graaf

Moll

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Although pineoblastoma is the main brain abnormality associated with hereditary retinoblastoma, recent studies suggest an association with pineal cysts. This association is important because some pineoblastomas mimic pineal cysts. If there is a relationship, then radiologists should be aware of it because diagnostic confusion is possible. Mental retardation and congenital brain anomalies are also reported in patients with retinoblastoma, mostly in combination with 13q deletion syndrome. In this retrospective study, the presence of brain abnormalities on MR images in a large group of consecutive patients with retinoblastoma is evaluated.

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Pineal Cyst Simulating Pinealoblastoma in 11 Children With Retinoblastoma

Cited by 17 publications

References 5 publications

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Basic understanding of current classification and management of retinoblastoma

Brain Abnormalities on MR Imaging in Patients with Retinoblastoma

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