Pindolol potentiates the panicolytic effect of paroxetine in the elevated T-maze

Abstract

the present results show that the combination of the ineffective doses of pindolol and paroxetine significantly increased escape latency, indicating a selective panicolytic effect. These findings give preclinical support for the use of this drug combination in the treatment of panic disorder (PD).

Molecular Docking and Panicolytic Effect of 8-Prenylnaringenin in the Elevated T-Maze

“…21) As a consequence, the ETM is considered a sound animal model of both anxiety and panic. 22,23) Regarding panic, performance of the one-way escape in the ETM has been shown to be impaired by several antidepressant drugs following chronic, but not acute, administration, paralleling the therapeutic response.…”