PINCH Expression and Its Clinicopathological Significance in Gastric Adenocarcinoma

Zhu, Zhen-Long; Yan, Bowei; Yang, Yongfeng; Wang, Zhengmin; Zhang, Hongzhen; Wang, Mingwei; Zhang, Xianghong; X, Sun

doi:10.1155/2012/895713

Cited by 6 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PINCH-1 promotes B-cell lymphoma (Bcl)-2-dependent survival signalling and inhibits c-Jun N-terminal kinase (JNK)-mediated apoptosis in the PrE (13). Although the function of PINCH remains unknown, increasing numbers and accumulating evidence indicates that PINCH has been correlated with cancer development, invasion and metastasis in malignant cells, including breast cancer (14), pseudomyxoma peritonei (15), gastric adenocarcinoma (16) and rectal cancer (17). For example, PINCH is demonstrated to protect tumor cells from apoptosis by increasing the activity of the pro-survival protein extracellular signal-regulated kinase (ERK)1/2 and Akt (18).…”

Section: Introductionmentioning

confidence: 99%

Particularly interesting Cys-His-rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture

Peng

Shi

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Particularly interesting Cys-His-rich protein (PINCH) has several biological functions in cancer development, invasion and metastasis in malignant cells, and the expression of PINCH is upregulated in several cancer types, including breast cancer, gastric adenocarcinoma and rectal cancer. However, the contribution of PINCH to human cerebral aneurysms remains largely unknown. Therefore, the significance of PINCH expression in cerebral aneurysm growth and rupture was examined in the present study. The protein expression levels of alpha-smooth muscle actin, osteopontin (OPN), matrix metalloproteinase (MMP) 9 and PINCH were evaluated using immunohistochemistry and western blot analyses. The results demonstrate that the protein expression levels of OPN, MMP9 and PINCH in the unruptured intracranial aneurysm (UA) and ruptured intracranial aneurysm (RA) groups were markedly higher than those of the control group, whereas OPN and PINCH expression levels were decreased in the RA group compared to those of the UA group. In addition, there was a strong correlation between PINCH and tumor size (r=0.650 and P=0.0026), as well as between PINCH and OPN (r=0.639 and P=0.0033) in the unruptured cerebral aneurysms. However, the correlation between PINCH and tumor size (r=0.450 and P=0.1393) and between PINCH and OPN (r=0.366 and P=0.2426) revealed no obvious difference in the ruptured cerebral aneurysms. In conclusion, PINCH was highly expressed in the UAs, which may be a critical factor for preventing aneurysmal rupture. Moreover, PINCH may facilitate intracranial aneurysm progression, at least partially, through the activation of extracellular signal-regulated kinase signaling and the suppression of c-Jun N-terminal kinase signaling.

show abstract

Section: Introductionmentioning

confidence: 99%

Particularly interesting Cys-His-rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture

Peng

Shi

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Among the top 10 DRGs for Chinese (GSE54129), six genes have been reported to be gastric cancer (GC) related (REG4 [ 34 ], ANXA13 [ 35 ], C7 [ 36 ], ASS1 [ 37 ], MSMB [ 38 ], CREB1 [ 39 ]) and the rest four were directly regulated by known gastric cancer genes in our GRNs, in which two genes are also cancer related (BPTF [ 40 ], CLCA1 [ 41 ]). Among the top 10 DRGs identified for Korean (GSE24375), six genes are GC related (ESRRG [ 42 ], LIMS1 [ 43 , 44 ], GATA3 [ 45 ], GATA6 [ 46 ], SOX9 [ 47 ], POU2F1 [ 48 ]) and the other four are cancer related (IRF2 [ 49 ], RGS3 [ 50 ], MRPL36 [ 51 ], FOSB [ 52 ]). Among the top 10 DRGs identified from TCGA-STAD dataset, six are GC related (E2F1 [ 50 ], AK1B10 [ 51 ], CEBPA [ 52 ], PTK7 [ 53 ], RASAL1 [ 54 ], GKN [ 55 ]), and three are cancer related (DPCR1 [ 56 ], GGT6 [ 57 ], RAB25 [ 58 ]).…”

Section: Resultsmentioning

confidence: 99%

Differential networking meta-analysis of gastric cancer across Asian and American racial groups

Dai

Liu

et al. 2018

BMC Syst Biol

View full text Add to dashboard Cite

BackgroundGastric Carcinoma is one of the most lethal cancer around the world, and is also the most common cancers in Eastern Asia. A lot of differentially expressed genes have been detected as being associated with Gastric Carcinoma (GC) progression, however, little is known about the underlying dysfunctional regulation mechanisms. To address this problem, we previously developed a differential networking approach that is characterized by involving differential coexpression analysis (DCEA), stage-specific gene regulatory network (GRN) modelling and differential regulation networking (DRN) analysis.ResultIn order to implement differential networking meta-analysis, we developed a novel framework which integrated the following steps. Considering the complexity and diversity of gastric carcinogenesis, we first collected three datasets (GSE54129, GSE24375 and TCGA-STAD) for Chinese, Korean and American, and aimed to investigate the common dysregulation mechanisms of gastric carcinogenesis across racial groups. Then, we constructed conditional GRNs for gastric cancer corresponding to normal and carcinoma, and prioritized differentially regulated genes (DRGs) and gene links (DRLs) from three datasets separately by using our previously developed differential networking method. Based on our integrated differential regulation information from three datasets and prior knowledge (e.g., transcription factor (TF)-target regulatory relationships and known signaling pathways), we eventually generated testable hypotheses on the regulation mechanisms of two genes, XBP1 and GIF, out of 16 common cross-racial DRGs in gastric carcinogenesis.ConclusionThe current cross-racial integrative study from the viewpoint of differential regulation networking provided useful clues for understanding the common dysfunctional regulation mechanisms of gastric cancer progression and discovering new universal drug targets or biomarkers for gastric cancer.Electronic supplementary materialThe online version of this article (10.1186/s12918-018-0564-z) contains supplementary material, which is available to authorized users.

show abstract

“…Three levels were used to categorize the staining diffuseness (0-3): "grade 0" indicated less than or equal to 5%, "grade 1" between 6% and 34%, "grade 2" between 35% and 49%, and "grade 3" more than 50%. Additionally, the intensity was assessed using a scale ranging from negative (0), mild (+1), moderate (+2), and strong (+3) (Figure 1) (9,(19)(20)(21).…”

Section: Immunohistochemistrymentioning

confidence: 99%

Over Seröz Karsi̇nomunda Ve Borderli̇ne Seröz Tümörde İmmünhi̇stoki̇myasal Pinch/Lims-1 Anti̇kor Ekspresyonunun Kli̇ni̇kopatoloji̇k Değeri̇

ERTUNÇ,

ERDEM,

KAYMAK

2023

SDÜ Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Objective: Particularly interesting cys-his rich protein (PINCH), a protein implicated in cell adhesion, is assumed to oversee the development and invasion of cancer cells in tumors and tumor-associated stroma. This study aimed to assess PINCH-1 expression in serous borderline tumor (SBT) and serous carcinoma (SC) in the tumor and peritumoral stroma and scrutinize any associations between its expression and various clinical and pathological parameters. Material and Methods: In this study, the expression of the PINCH-1 antibody was analyzed in 21 cases of SBT and 89 cases of SC using the indirect immunoperoxidase technique with streptavidin/HRP-biotin. The staining pattern of PINCH-1 in the tumor and peritumoral stroma was evaluated using a semiquantitative scoring method. The staining method used in the study allowed for accurate identification of PINCH-1 expression, and the data obtained through the semiquantitative scoring method provided a reliable of assessing the degree and intensity of PINCH-1 staining. Thus, the correlation between PINCH-1 expression and various pathologic factors such as patient age, tumor size, FIGO stage, intra-abdominal washing cytology, capsule invasion, tumor location in the ovary, tumor grade, and CA125 levels at the time of diagnosis was examined. Results: The study found that PINCH-1 was more prevalent in cases of SC than in SBT cases. The tumors in SC cases had stronger staining than those in SBT cases (p

show abstract

PINCH Expression and Its Clinicopathological Significance in Gastric Adenocarcinoma

Cited by 6 publications

References 24 publications

Particularly interesting Cys-His-rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture

Particularly interesting Cys-His-rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture

Differential networking meta-analysis of gastric cancer across Asian and American racial groups

Over Seröz Karsi̇nomunda Ve Borderli̇ne Seröz Tümörde İmmünhi̇stoki̇myasal Pinch/Lims-1 Anti̇kor Ekspresyonunun Kli̇ni̇kopatoloji̇k Değeri̇

Contact Info

Product

Resources

About