Pincer Ligands as Multifunctional Agents for Alzheimer's Copper Dysregulation and Oxidative Stress: A Computational Evaluation
Nicolás Puentes‐Díaz,
Diego Chaparro,
David Morales‐Morales
et al.
Abstract:Alzheimer’s disease (AD) is the most common form of dementia worldwide, affecting millions of people around the globe. AD is characterized by different pathologies being beta‐amyloid (Aβ) plaque formation, metal ion dysregulation, and oxidative stress central topics under investigation. Copper‐Aβ complexes have been shown to induce catalytic hydrogen peroxide formation and increase OS in the brain leading to neuronal death. Pincer‐type compounds are tridentate ligands that coordinate metals in a planar fashion… Show more
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