Pinacol Coupling of Aromatic Aldehydes using La‐Ticl<sub>4</sub> in CH<sub>3</sub>COOEt under Ultrasound Irradiation

Li, Ji‐Tai; Sun, Xue-Li; Lin, Zheng‐Zhe; Li, Tong‐Shuang

doi:10.1155/2006/107491

Cited by 1 publication

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“…This is because the data showed the H-1 (δH 4.84) has a relationship with H-1' (δH 4.84). From the previously reported data by Ji-Tai Li in 2006 [16], resonance δH 4.84 is referring to meso-proton in the structure which can form meso stereoisomers. The DEPT spectrum obtained further verified the presence of seven carbons in each side of the meso compound.…”

Section: Structural Elucidation Of Compoundsmentioning

confidence: 99%

Antibacterial and Antiplasmodial Properties of Chemical Compounds Isolated from Bark of Phyllanthus acidus (L.) Skeels

2021

MJCHEM

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Phyllanthus acidus (L.) Skeels (Phyllanthaceae family) is a plant that is widely distributed in Asian countries, which is traditionally used as a medicinal plant to treat various ailments. Inspired by the uses of the plant, the aim of this study was to extract and isolate bioactive compounds from P. acidus as potential antimicrobials. The isolation and identification of phyllanthol (1) and meso-hydrobenzoin (2) from the dichloromethane bark extract of P. acidus are presented. The structures of these compounds were elucidated by extensive spectroscopic analyses. To the best of our knowledge, compound 1 is a known compound and compound 2 is the first report presented on the isolation and structural elucidation as a natural compound. The bark extract and the isolated compounds were evaluated for antibacterial activities against Escherichia coli, Enterococcus faecium, Pseudomonas aeruginosa, and Staphylococcus aureus by disc diffusion assay, minimal inhibitory concentration (MIC), and half-maximal inhibitory concentration (IC50). Compounds 1 and 2 showed significant activities against Escherichia coli (IC50 value = 0.42 and 0.47 μg/mL, respectively), Enterococcus faecium (IC50 value = 0.86 and 0.43 μg/mL, respectively), Pseudomonas aeruginosa (IC50 value = 0.45 and 0.44 μg/mL, respectively), and Staphylococcus aureus (IC50 value = 12.87 and 0.44 μg/mL, respectively). These compounds also showed significant antiplasmodial activities towards the 3D7 strain with IC50 value of 0.218 μM for compound 1 and 0.228 μM for compound 2, in vitro. All the isolated compounds were not active against MRC-5 cells with an IC50 value of more than 60 μg/mL. From the results obtained, P. acidus has been proven as a source of molecules with therapeutic potentials.

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Section: Structural Elucidation Of Compoundsmentioning

confidence: 99%

Antibacterial and Antiplasmodial Properties of Chemical Compounds Isolated from Bark of Phyllanthus acidus (L.) Skeels

2021

MJCHEM

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Pinacol Coupling of Aromatic Aldehydes using La‐Ticl₄ in CH₃COOEt under Ultrasound Irradiation

Abstract: Titanium tetrachloride can be reduced by lanthanum filings to the corresponding low valent titanium complex, which can induce some aromatic aldehydes to the corresponding pinacols in 28%-97% yields within 10-50 min in ethyl acetate at r.t. under ultrasound irradiation.

Cited by 1 publication

References 9 publications

Antibacterial and Antiplasmodial Properties of Chemical Compounds Isolated from Bark of Phyllanthus acidus (L.) Skeels

Antibacterial and Antiplasmodial Properties of Chemical Compounds Isolated from Bark of Phyllanthus acidus (L.) Skeels

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Pinacol Coupling of Aromatic Aldehydes using La‐Ticl4 in CH3COOEt under Ultrasound Irradiation

Abstract: Titanium tetrachloride can be reduced by lanthanum filings to the corresponding low valent titanium complex, which can induce some aromatic aldehydes to the corresponding pinacols in 28%-97% yields within 10-50 min in ethyl acetate at r.t. under ultrasound irradiation.

Cited by 1 publication

References 9 publications

Antibacterial and Antiplasmodial Properties of Chemical Compounds Isolated from Bark of Phyllanthus acidus (L.) Skeels

Antibacterial and Antiplasmodial Properties of Chemical Compounds Isolated from Bark of Phyllanthus acidus (L.) Skeels

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Pinacol Coupling of Aromatic Aldehydes using La‐Ticl₄ in CH₃COOEt under Ultrasound Irradiation