PIN60 Cost-Effectiveness of Quadrivalent Influenza Vaccine High Dose Versus Adjuvanted Standard Dose Trivalent Influenza Vaccine in England

Gibbons, I.; Davidson, Craig; Clark-Wright, J.; Miller, C.; Carroll, Stuart; Costa, M.; Bricout, Hélène; Álvarez, Francisco Blanco

doi:10.1016/j.jval.2020.08.901

Cited by 1 publication

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“…The rVE estimate of 24.2% for HD-TIV/HD-QIV versus TIV/QIV for LCI cases, based on results from the FIM12 RCT [50], was consistently used in CEA comparing HD-TIV/HD-QIV versus TIV/QIV, and used in CEA that indirectly compared the rVE of HD-TIV/HD-QIV versus aTIV/aQIV (Tables 2B and 3B; Figure 2). [65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81]. Note: no value indicates that a comparison was not evaluated.…”

Section: Comparison Between Cea For Enhanced and Standard Vaccinesmentioning

confidence: 99%

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Real-World Evidence in Cost-Effectiveness Analysis of Enhanced Influenza Vaccines in Adults ≥ 65 Years of Age: Literature Review and Expert Opinion

et al. 2023

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Influenza vaccination can benefit most populations, including adults ≥ 65 years of age, who are at greater risk of influenza-related complications. In many countries, enhanced vaccines, such as adjuvanted, high-dose, and recombinant trivalent/quadrivalent influenza vaccines (aTIV/aQIV, HD-TIV/HD-QIV, and QIVr, respectively), are recommended in older populations to provide higher immunogenicity and increased relative vaccine efficacy/effectiveness (rVE) than standard-dose vaccines. This review explores how efficacy and effectiveness data from randomized controlled trials and real-world evidence (RWE) are used in economic evaluations. Findings from published cost-effectiveness analyses (CEA) on enhanced influenza vaccines for older adults are summarized, and the assumptions and approaches used in these CEA are assessed alongside discussion of the importance of RWE in CEA. Results from many CEA showed that adjuvanted and high-dose enhanced vaccines were cost-effective compared with standard vaccines, and that differences in rVE estimates and acquisition price may drive differences in cost-effectiveness estimates between enhanced vaccines. Overall, RWE and CEA provide clinical and economic rationale for enhanced vaccine use in people ≥ 65 years of age, an at-risk population with substantial burden of disease. Countries that consider RWE when making vaccine recommendations have preferentially recommended aTIV/aQIV, as well as HD-TIV/HD-QIV and QIVr, to protect older individuals.

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Section: Comparison Between Cea For Enhanced and Standard Vaccinesmentioning

confidence: 99%

“…Figure 2. rVE as used in base-case analyses of HD-TIV/HD-QIV compared with TIV/QIV or aTIV/aQIV[65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81]. Note: no value indicates that a comparison was not evaluated.…”

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confidence: 99%