Pin18 Burden of Illness of Herpes Zoster in Colombia: An Observational Study

Rampakakis, Emmanouil; Monsanto, H; Stutz, Melissa; Psaradellis, Eliofotisti; Mejía, G.S.; Carillo, Andrés Eduardo Rico; Zapata-Cárdenas, Andrés; Molina, David; Salazar, D.I. Molina de; Pradilla, Oscar; Beltran-Rodriguez, C.; Johnson, Kelly

doi:10.1016/j.vhri.2019.08.249

Cited by 3 publications

(3 citation statements)

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“…The pooled proportion of PHN in immunosuppressed patients and the immunocompetent population was 22% (95% CI = 20%-25%; I 2 = 0%) and 16% (95% CI = 12%-21%; I 2 = 94%), respectively. Three studies (Rampakakis 2017, Rampakakis 2019 [ 56 ] and Vujacich 2016 [ 44 ]) were excluded from the meta-analysis, since all eligible patients included were those with pain associated with HZ (acute neuritis or PHN). Regarding OHZ, a pooled proportion of 3.4% was found in immunosuppressed patients (95% CI = 0.7% to 8%; I2 = 77.6%).…”

Section: Resultsmentioning

confidence: 99%

Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis

et al. 2021

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The epidemiology and burden of Herpes Zoster (HZ) are largely unknown, and there are no recent reviews summarizing the available evidence from the Latin America and Caribbean (LAC) region. We conducted a systematic review and meta-analysis to characterize the epidemiology and burden of HZ in LAC. Bibliographic databases and grey literature sources were consulted to find studies published (January 2000 –February 2020) with epidemiological endpoints: cumulative incidence and incidence density (HZ cases per 100,000 person-years), prevalence, case-fatality rates, HZ mortality, hospitalization rates, and rates of each HZ complication. Twenty-six studies were included with most studies coming from Brazil. No studies reported the incidence of HZ in the general population. In population at higher risk, the cumulative incidence ranged from 318–3,423 cases of HZ per 100,000 persons per year of follow-up. The incidence density was 6.4–36.5 cases per 1,000 person-years. Age was identified as a major risk factor towards HZ incidence which increase significantly in people >50 years of age. Hospitalization rates ranged from 3%–35.7%. The in-hospital HZ mortality rate ranged from 0%–36%. Overall, HZ mortality rates were found to be higher in females across all age groups and countries. The incidence of HZ complications (such as post-herpetic neuralgia, ophthalmic herpes zoster, and Ramsay Hunt syndrome) was higher in the immunosuppressed compared to the immunocompetent population. Acyclovir was the most frequently used therapy. Epidemiological data from Ministry of Health databases (Argentina, Brazil, Colombia, Chile y Mexico) and Institute for Health Metrics and Evaluation’s Global Burden of Disease project reported stable rates of hospitalizations and deaths over the last 10 years. High-risk groups for HZ impose a considerable burden in LAC. They could benefit from directed healthcare initiatives, including adult immunization, to prevent HZ occurrence and its complications.

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Section: Resultsmentioning

confidence: 99%

Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis

et al. 2021

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“…The risk of bias assessment of case series and cohort studies reporting resource usage has been reported elsewhere and is shown in Tables S1 and S2, respectively. Seventy-five percent of the cohort studies 49 , 56 , 61 , 67 and 91% of the case series/epidemiological surveillance studies 47 –48-50–51-53–55-57–66-68– 69 were assessed as having low risk of bias.…”

Section: Resultsmentioning

confidence: 99%

Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis

Balan

Bardach

Palermo

et al. 2022

Human Vaccines & Immunotherapeutics

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This systematic review describes herpes zoster (HZ) economic burden in terms of healthcare resource use and cost outcomes in the Latin America and Caribbean (LAC) region. We searched online databases from 1 January 2000 to 20 February 2020 to identify eligible publications. We identified 23 publications that reported direct costs, indirect costs, and resources associated with HZ and its complications. The primary direct medical resources reported in the different studies were visits to doctors, transportation, days in the hospital, nursing, medication schedules, and physical therapy. Direct total costs per patient ranged from $99.99 to $4177.91. The highest cost was found in Brazil. Direct costs are, in average, 81.39% higher than indirect costs. The cost per patient that includes postherpetic neuralgia treatment is 115% higher on average for the directs and 73% for the indirect costs. Brazil reported a higher total cost per patient than Argentina and Mexico, while for indirect costs per patient, Brazil and Argentina had higher costs than Mexico, respectively. A meta-analysis on the number of days due to HZ hospitalization, performed on non-immunosuppressed patients over 65 years of age from three studies, resulted in a cumulative measure of 4.5 days of hospitalization. In the LAC region, the economic burden of HZ and associated complications is high, particularly among high-risk populations and older age groups. Preventative strategies such as vaccination could help avoid or reduce the HZ-associated disease economic burden in the LAC region.

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“…The database search returned 651 records of which 142 duplicates were removed. 509 records were analyzed through title and abstract screening and 495 records were excluded, with a total of 14 records remaining for full text screening [26][27][28][29][30][31][32][33][34][35][36][37][38]. Additional 336 papers were retrieved by citation tracking, of which 11 full-text records were assessed [9,29,[39][40][41][42][43][44][45][46][47].…”

Section: Study Selectionmentioning

confidence: 99%

Multidimensional versus unidimensional pain scales for the assessment of analgesic requirement in the emergency department: a systematic review

Crisman,

Appenzeller-Herzog,

Tabakovic

et al. 2024

Intern Emerg Med

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Pain is a multidimensional experience, potentially rendering unidimensional pain scales inappropriate for assessment. Prior research highlighted their inadequacy as reliable indicators of analgesic requirement. This systematic review aimed to compare multidimensional with unidimensional pain scales in assessing analgesic requirements in the emergency department (ED). Embase, Medline, CINAHL, and PubMed Central were searched to identify ED studies utilizing both unidimensional and multidimensional pain scales. Primary outcome was desire for analgesia. Secondary outcomes were amount of administered analgesia and patient satisfaction. Two independent reviewers screened, assessed quality, and extracted data of eligible studies. We assessed risk of bias with the ROBINS-I tool and provide a descriptive summary. Out of 845 publications, none met primary outcome criteria. Three studies analyzed secondary outcomes. One study compared the multidimensional Defense and Veterans Pain Rating Scale (DVPRS) to the unidimensional Numerical Rating Scale (NRS) for opioid administration. DVPRS identified more patients with moderate instead of severe pain compared to the NRS. Therefore, the DVPRS might lead to a potential reduction in opioid administration for individuals who do not require it. Two studies assessing patient satisfaction favored the short forms (SF) of the Brief Pain Inventory (BPI) and McGill Pain Questionnaire (MPQ) over the Visual Analogue Scale (VAS) and the NRS. Limited heterogenous literature suggests that in the ED, a multidimensional pain scale (DVPRS), may better discriminate moderate and severe pain compared to a unidimensional pain scale (NRS). This potentially impacts analgesia, particularly when analgesic interventions rely on pain scores. Patients might prefer multidimensional pain scales (BPI-SF, MPQ-SF) over NRS or VAS for assessing their pain experience.

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Pin18 Burden of Illness of Herpes Zoster in Colombia: An Observational Study

Cited by 3 publications

References 0 publications

Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis

Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis

Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis

Multidimensional versus unidimensional pain scales for the assessment of analgesic requirement in the emergency department: a systematic review

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