Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation
Jessica Jeong,
Muhammad Usman,
Yitong Li
et al.
Abstract:The unique prolyl isomerase Pin1 binds to and catalyzes cis–trans conformational changes of specific Ser/Thr-Pro motifs after phosphorylation, thereby playing a pivotal role in regulating the structure and function of its protein substrates. In particular, Pin1 activity regulates the affinity of a substrate for E3 ubiquitin ligases, thereby modulating the turnover of a subset of proteins and coordinating their activities after phosphorylation in both physiological and disease states. In this review, we highlig… Show more
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