Pimozide Injections into the <i>Nucleus accumbens</i> Disrupt Maternal Behaviour in Lactating Rats

Silva, Maria Rita P.; Bernardi, Maria Martha; Cruz‐Casallas, Pablo E.; Felício, Luciano Freitas

doi:10.1034/j.1600-0773.2003.930106.x

Cited by 57 publications

(51 citation statements)

References 35 publications

(33 reference statements)

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“…Dopamine system stimulation through the use of agonists, particularly D2 receptor agonists, has been shown to promote the release of peripheral oxytocin (Amico et al, 1992(Amico et al, , 1993Crowley et al, 1992;Parker and Crowley, 1992), while administration of dopamine antagonists results in a significant disruption in pup retrieval, nest building, and motor activity in general (Byrnes et al, 2002;Giordano et al, 1990;Keer and Stern, 1999;Silva et al, 2001Silva et al, , 2003Stern and Keer, 1999). As Stern and Keer (1999) suggest, this could potentially be due to the dopamine system involvement in motivation and reward.…”

Section: Introductionmentioning

confidence: 99%

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Johns

Joyner

McMurray

et al. 2005

Pharmacology Biochemistry and Behavior

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Studies using dopaminergic and serotonergic agonists or antagonists implicate involvement of these systems in various aspects of early maternal behavior and postpartum aggression towards an intruder in rats, both of which are associated with the presence of oxytocin in specific brain regions. It is unclear however, if or how long-term uptake inhibition of either neurotransmitter system alone or in combination, affects oxytocin system dynamics or maternal behavior/ aggression. Pregnant women frequently take drugs (antidepressants, cocaine) that induce longterm reuptake inhibition of dopamine and/or serotonin, thus it is important to understand these effects on behavior and biochemistry. Rat dams were treated throughout gestation with amfonelic acid, fluoxetine, or a combination of both, to investigate effects of reuptake inhibition of dopamine and serotonin systems respectively, on maternal behavior, aggression and oxytocin. The more appetitive aspects of maternal behavior (nesting, licking, touching) and activity were increased by the low dose of amfonelic acid, high dose of fluoxetine, or the high dose combination more than other treatments. Aggression was decreased by amfonelic acid and somewhat increased by fluoxetine. Dopamine uptake inhibition appears to have a strong effect on hippocampal oxytocin levels, while receptor dynamics may be more strongly affected by serotonin uptake inhibition.

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Section: Introductionmentioning

confidence: 99%

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Johns

Joyner

McMurray

et al. 2005

Pharmacology Biochemistry and Behavior

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show abstract

“…Manipulations of the dopamine system have been strongly associated with alterations in various aspects of maternal behavior and affect aspects of oxytocin. D2 receptor agonists particularly promote the release of peripheral oxytocin (Amico et al, 1992;Amico et al, 1993;Crowley et al, 1992;Parker and Crowley, 1992), while administration of dopamine antagonists results in a significant disruption in pup retrieval, nest building, and motor activity in general (Byrnes et al, 2002;Giordano et al, 1990;Keer and Stern, 1999;Silva et al, 2001;Silva et al, 2003;Stern and Keer, 1999).…”

Section: Discussionmentioning

confidence: 99%

Impact of gestational cocaine treatment or prenatal cocaine exposure on early postpartum oxytocin mRNA levels and receptor binding in the rat

et al. 2008

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Prior research reported decreased oxytocin levels in specific brain regions correlated with disruptions in maternal care following gestational cocaine treatment in rats. Similarly, prenatal exposure to cocaine impaired subsequent maternal behavior in adulthood, but behavioral alterations were not associated with decreases in oxytocin levels in the same brain regions as were found in their cocainetreated rat dams. To determine if other aspects of the oxytocin system are disrupted by cocaine treatment or prenatal exposure to cocaine during critical time points associated with maternal care, oxytocin mRNA transcription and receptor binding were examined on postpartum day two in relevant brain regions following gestational treatment with, or prenatal exposure to, either cocaine or saline. We hypothesized that oxytocin mRNA levels and receptor binding would be differentially affected by cocaine in the early postpartum period of dams and their offspring. Our findings indicate that gestational cocaine treatment resulted in significant increases in oxytocin mRNA levels in only the paraventricular nucleus of cocaine-treated dams, with almost significant increases in both generations in the supraoptic nucleus, but no significant effects of cocaine on receptor binding in either generation of dams. These findings indicate that in addition to oxytocin levels, cocaine treatment or prenatal exposure primarily affects oxytocin mRNA synthesis, with little effect on receptor binding in specific brain regions associated with maternal behavior in the early postpartum period of the rat.

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“…Thus, limbic dopaminergic pathways play a role in ongoing maternal behavior (Silva et al, 2001(Silva et al, , 2003. Projections from MPOA/vBNST neurons to the lateral septum (LS) appear to have functional implications in terms of promoting maternal behavior (Numan, 2006).…”

Section: Activation Pathwaysmentioning

confidence: 99%

Dynamics of mother–pup interactions: Tradeoff between environment and physiology.

Vasconcelos¹,

Klein²,

Cruz³

et al. 2012

Psychology & Neuroscience

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The emergence and maintenance of maternal behavior are under the influence of environmental cues such as light and dark periods. This article discusses the characteristic neurobiology of the behavioral patterns of lactating rats. Specifically, the hormonal basis and neurocircuits that determine whether mother rats show typical sequential patterns of behavioral responses are discussed. During lactation, rats express a sequential pattern of behavioral parameters that may be determined by hormonal variations. Sensorial signals emitted by pups, as well as environmental cues, are suggested to serve as conditioned stimuli for these animals. Finally, the expression of maternal behavior is discussed under neuroeconomic and evolutionary perspectives.

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Pimozide Injections into the Nucleus accumbens Disrupt Maternal Behaviour in Lactating Rats

Cited by 57 publications

References 35 publications

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Impact of gestational cocaine treatment or prenatal cocaine exposure on early postpartum oxytocin mRNA levels and receptor binding in the rat

Dynamics of mother–pup interactions: Tradeoff between environment and physiology.

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