Pimozide combined with behavior therapy in the short‐term treatment of anorexia nervosa

Vandereycken, Walter; Pierloot, Roland

doi:10.1111/j.1600-0447.1982.tb04501.x

Cited by 149 publications

(62 citation statements)

References 17 publications

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“…On long-term study, chlor pro maz ine yielded no greater weight gain than that noted in his tori cal con trol groups. Other do pa mine an tago nists were ex am ined in double-blind placebo-controlled stud ies (pimozide [8] and sul piride [9]). While pi mozide re sulted in some weight gain over pla cebo, sul piride pro vided no sig nificant bene fit.…”

Section: An Tipsy Chot Icsmentioning

confidence: 99%

Pharmacologic Treatment of Eating Disorders

2002

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Key Words: phar ma cologic treat ment, eat ing dis or ders, ano rexia ner vosa, bu li mia nervosa, binge eat ing dis or der, BEDA no rexia ner vosa (AN), bu li mia ner vosa (BN), and binge eat ing dis or der (BED) are se ri ous con di tions that im pair both psy cho logi cal and physi cal health. More preva lent in indus tri al ized na tions, these ill nesses af fect all so cio eco nomic classes of every eth nic ity in North Amer ica (1). Eat ing dis orders (EDs) af fect pri mar ily women, with only 5% to 15% of AN and BN pa tients and 40% of BED pa tients be ing boys or men (2,3). Three per cent of women will be af fected by EDs over their life time (4). Col lec tively, EDs are char ac ter ized by se vere dis tur bances in eat ing be hav iour as well as dis tress over body shape and weight.While the eti ol ogy of ED re mains elu sive, cul tural, en vi ronmental, de vel op men tal, bio logi cal, and ge netic fac tors may all play a role in their de vel op ment. In ad di tion to stud ies of the physio logi cal and psy cho so cial as pects of ED, much re search has been de voted to their phar ma cologic ther apy. This pa per re views the role of medi ca tion in the treat ment of AN, BN, and BED. Ano rexia Ner vosaAN is ar gua bly the most le thal of psy chi at ric ill nesses (5). The key di ag nos tic fea tures of AN com prise re fusal to main tain at least 85% of nor mal body weight, dis tur bances in body im age, in tense fear of be com ing fat, and ame nor rhea in post men archal girls and women. DSM-IV sug gests 2 cate go ries of AN: the re strict ing sub type and the binge or purge sub type. Patients usu ally ap pear ema ci ated, and the vi cious cy cle of di eting and weight loss can lead to se ri ous physio logi cal dis rup tions, in clud ing leu ko penia, ar rhyth mias, pro longed QT in ter val, en do crine ab nor mali ties, and os teo po ro sis. As Ob jec tive: Eat ing dis or ders are a se ri ous group of con di tions that af fect 3% of women in in dus tri al ized na tions over their life times. Re cent years have seen con sid er able prog ress in the treat ment of these dis or ders. This ar ti cle re views the cur rent body of evi dence for the phar ma cologic treat ment of eat ing dis or ders Method:We un der took a lit era ture re view.Re sults: For pa tients with ano rexia ner vosa (AN), drug tri als have been dis ap point ing. In con trast, nu mer ous stud ies have dem on strated a clear role for an ti de pres sants in the treatment of bu li mia ner vosa (BN). Phar ma cologic in ves ti ga tions of binge eat ing dis or der (BED), a more re cently de fined en tity, have iden ti fied sev eral prom is ing drugs. There is also sup port for the util ity of com bined medi ca tion and psy cho ther apy. Con clu sion:Con tin ued re search ef forts are nec es sary, par ticu larly re gard ing the long-term ef fects of ther apy and the de vel op ment of new phar ma cologic strate gies.(Can J Psy chia try 2002;47:227-234) Clini cal Im pli ca tion• Medi ca tion treat ment has es tab lished util ity in cases of bu l...

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Section: An Tipsy Chot Icsmentioning

confidence: 99%

Pharmacologic Treatment of Eating Disorders

2002

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“…The anorexics on com bined treatment maintained their body weights for a lon ger time after the end of the trial. Vandereeycken and Pierloot [8] treated 20 hospitalized anorexics with a short term combination of pimozide and behavior therapy, with the drug apparently enhancing the effect of the psy chological treatment. The same phenomenon was ob served by Munford et al [9], who administered imipra mine and behavior therapy for a short period to one hos pitalized anorexic patient, the drug enhancing the im provement of depression.…”

Section: Introductionmentioning

confidence: 99%

Combined Cognitive-Behavioral, Psychopharmacological and Nutritional Therapy in Eating Disorders

et al. 1995

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Twenty-two female patients with anorexia nervosa, restricted type, 14–35 years old, were treated with a 4-month course of combined cognitive-behavioral therapy, nutritional counselling and antidepressant drugs (nortriptyline for 7, fluoxetine for 15). Patients were monitored for body mass index (BMI), for eating disorder symptoms by the Eating Disorder Inventory (EDI) and the Bulimic Investigation Test (BITE) and for depression and anxiety by the Hamilton Rating Scales for Depression and for Anxiety (HRS-D and -A). The scores were determined before and after 1, 2 and 4 months of therapy. BMI, depression, anxiety and EDI scores improved significantly and equally in both groups during the 4 months of therapy, while BITE scores did not change.

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“…Controlled studies on chlorpromazine (Dally and Sargant 1966) and pimozide (Vandereycken and Pierloot 1982) showed increased weight gain and a more positive attitude of AN patients toward treatment, whereas the atypical antipsychotic sulpiride did not significantly influence body weight gain and eating and body attitudes in AN patients (Vandereycken 1984).…”

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confidence: 99%