Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules

Haase, Anne‐Mette; Gregersen, Tine; Schlageter, Vincent; Scott, Mark; Demierre, Michel; Kučera, Pavel; Dahlerup, Jens Frederik; Krogh, Klaus

doi:10.1111/nmo.12461

Cited by 54 publications

(146 citation statements)

References 33 publications

(28 reference statements)

Supporting

Mentioning

144

Contrasting

Order By: Relevance

“…[16][17][18][19] Hence, the pan-enteric impact of opioid treatment can be accurately assessed, providing new insight into altered motility patterns. 20 However, opioid treated patients often suffer from comorbidities and concomitant drug use, which complicates evaluation of the underlying pathophysiological mechanisms. Consequently, an experimental model in healthy volunteers, where these limitations are minimized, is highly merited.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Opioid Treatment on Regional Gastrointestinal Transit

Poulsen

Nilsson

Brock

et al. 2016

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsTo employ an experimental model of opioid-induced bowel dysfunction in healthy human volunteers, and evaluate the impact of opioid treatment compared to placebo on gastrointestinal (GI) symptoms and motility assessed by questionnaires and regional GI transit times using the 3-dimensional (3D)-Transit system. MethodsTwenty-five healthy males were randomly assigned to oxycodone or placebo for 5 days in a double blind, crossover design. Adverse GI effects were measured with the bowel function index, gastrointestinal symptom rating scale, patient assessment of constipation symptom questionnaire, and Bristol stool form scale. Regional GI transit times were determined using the 3D-Transit system, and segmental transit times in the colon were determined using a custom Matlab ® graphical user interface. ResultsGI symptom scores increased significantly across all applied GI questionnaires during opioid treatment. Oxycodone increased median total GI transit time from 22.2 to 43.9 hours (P < 0.001), segmental transit times in the cecum and ascending colon from 5.7 to 9.9 hours (P = 0.012), rectosigmoid colon transit from 2.7 to 9.0 hours (P = 0.044), and colorectal transit time from 18.6 to 38.6 hours (P = 0.001). No associations between questionnaire scores and segmental transit times were detected. ConclusionsSelf-assessed GI adverse effects and increased GI transit times in different segments were induced during oxycodone treatment. This detailed information about segmental changes in motility has great potential for future interventional head-to-head trials of different laxative regimes for prevention and treatment of constipation.

show abstract

Section: Introductionmentioning

confidence: 99%

The Impact of Opioid Treatment on Regional Gastrointestinal Transit

Poulsen

Nilsson

Brock

et al. 2016

J Neurogastroenterol Motil

View full text Add to dashboard Cite

show abstract

“…18 Furthermore, the system has potential for detailed description of contraction patterns. The recent publication about 3D-Transit concluded that the system is safe, easy-to-use and provides valid data with only minimal data loss in healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

“…The patients with NET were generally older than the healthy subjects from our previous method study. 18 However, the oldest 4 subjects from our previous study were included in the present study along with another 11 healthy subjects of appropriate age. The study was conducted in accordance with the Declaration of Helsinki, approved by the local scientific ethics committee and the Danish Medical Agency (Eudract No.…”

Section: Patients and Healthy Volunteersmentioning

confidence: 99%

“…18 It consists of an electronic telemetric capsule for ingestion, a detector with four sensors mounted on the lower part of the abdomen, and dedicated software for real-time and post-experimental visualization and analysis (Fig. 1).…”

Section: D-transitmentioning

confidence: 99%

“…In a pilot study among healthy subjects, 3D-Transit was well-tolerated and provided valid information about GI transit times with only minimal data loss. 18 However, no data on the use of 3D-Transit has yet been published in any patient group. We hypothesized that 3D-Transit would be safe and well tolerated in this group of patients and that total GI transit times assessed with 3D-Transit are well correlated to those determined with standard radiopaque markers.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Regional Gastrointestinal Transit Times in Patients With Carcinoid Diarrhea: Assessment With the Novel 3D-Transit System

Gregersen

Haase

Schlageter³

et al. 2015

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsThe paucity of knowledge regarding gastrointestinal motility in patients with neuroendocrine tumors and carcinoid diarrhea restricts targeted treatment. 3D-Transit is a novel, minimally invasive, ambulatory method for description of gastrointestinal motility. The system has not yet been evaluated in any group of patients. We aimed to test the performance of 3D-Transit in patients with carcinoid diarrhea and to compare the patients' regional gastrointestinal transit times (GITT) and colonic motility patterns with those of healthy subjects. MethodsFifteen healthy volunteers and seven patients with neuroendocrine tumor and at least 3 bowel movements per day were investigated with 3D-Transit and standard radiopaque markers. ResultsTotal GITT assessed with 3D-Transit and radiopaque markers were well correlated (Spearman's rho = 0.64, P = 0.002). Median total GITT was 12.5 (range: 8.5-47.2) hours in patients versus 25.1 (range: 13.1-142.3) hours in healthy (P = 0.007). There was no difference in gastric emptying (P = 0.778). Median small intestinal transit time was 3.8 (range: 1.4-5.5) hours in patients versus 4.4 (range: 1.8-7.2) hours in healthy subjects (P = 0.044). Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012). Median frequency of pansegmental colonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045). ConclusionsThree-dimensional Transit allows assessment of regional GITT in patients with diarrhea. Patients with carcinoid diarrhea have

show abstract