Pilot Study to Evaluate the Efficacy of Hyperbaric Oxygen Therapy in Improving the Survival of Reattached Auricular Composite Grafts in the New Zealand White Rabbit

McClane, Stacie D.; Renner, Gregory J.; Bell, Patricia L.; Early, Elizabeth; Shaw, Bharat

doi:10.1067/mhn.2000.109473

Cited by 19 publications

(18 citation statements)

References 20 publications

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“…In support of this argument was the investigation by McClane et al 17 Again, using rabbits, they either amputated the tip as in the Henrich et al study 12 or performed a rectangular cut out from the lateral border of the ear (1.5 cm wide ϫ 4.0 cm long). In the latter case, there are now three borders from which the composite graft can acquire blood flow, and although the graft is 4 cm long, no area is less than 1.5 cm from a potential blood supply.…”

Section: Animal Studiesmentioning

confidence: 84%

An Evidence-Based Appraisal of the Use of Hyperbaric Oxygen on Flaps and Grafts

Friedman

Fitzmaurice

Lefaivre

et al. 2006

Plastic and Reconstructive Surgery

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Hyperbaric oxygen has been advocated, both as an adjunctive or primary form of treatment, for a variety of disorders, including gas gangrene, osteoradionecrosis, and carbon monoxide poisoning. It has also been used to improve ischemic wounds before skin grafting and to support ischemic flaps. In this review, we analyze the available literature that investigates the use of hyperbaric oxygen for composite grafts, skin grafts, random flaps, distant flaps, and free flaps. An appraisal of the level of evidence for each of these uses of hyperbaric oxygen is offered. Although there are a significant amount of animal data supporting the application of hyperbaric oxygen for grafts and flaps, there is very little clinical information other than case reports and series to sustain its choice over other modalities of therapy. Multicenter prospective clinical studies are clearly needed comparing hyperbaric oxygen to other mechanical or pharmacologic interventions to improve wound healing for grafting or to support flap survival.

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Section: Animal Studiesmentioning

confidence: 84%

An Evidence-Based Appraisal of the Use of Hyperbaric Oxygen on Flaps and Grafts

Friedman

Fitzmaurice

Lefaivre

et al. 2006

Plastic and Reconstructive Surgery

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“…Composite grafts at the base edge of the ear fared better, with a mean of 15.97% graft survival in HBO-treated rabbits. 26 In-growth of new blood vessels from 360°around the composite graft in the current study may have been a critical advantage. Second, the difference in HBO regimens may have contributed to the better outcome.…”

Section: Discussionmentioning

confidence: 86%

“…9,[13][14][15][16][17][18][19][20][21][22][23][24] In addition, several studies in animal models have shown some success in improving composite graft survival. 18,25,26 None of the studies to date have determined the maximum dimensions of composite grafts for HBO to be beneficial. The purpose of the current study is to establish a reproducible animal model for chondrocutaneous composite grafts and to study the effects of HBO therapy on graft survival at increasing graft diameters.…”

mentioning

confidence: 98%

The Effect of Hyperbaric Oxygen Therapy on Composite Graft Survival

Menon

Rodriguez³

et al. 2004

Annals of Plastic Surgery

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Auricular composite grafts are a useful reconstructive option, particularly for nasal reconstruction. This study evaluates the effect of hyperbaric oxygen (HBO) therapy on auricular composite graft survival in rabbits. Circular chondrocutaneous composite grafts of 0.5, 1, or 2 cm in diameter were resected from the ears of rabbits. The grafts were sutured back into position. Half the rabbits in each group received HBO postoperatively, consisting of 90 minutes at 2.4 atm. Rabbits received 7 treatments in 5 days. Control rabbits did not receive HBO. On day 21 the percentage area of graft survival was calculated from gross and histologic examination. Two-centimeter grafts treated with HBO (n = 8) had a mean graft survival rate of 85.8 +/- 15.7% compared with a survival rate of 51.31 +/- 38.5% for the control group (n = 8; P = 0.0478). There was no such benefit in smaller grafts. HBO could prove clinically useful for larger composite grafts.

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“…HBO improved the area of survival of reattached auricular composite grafts in New Zealand rabbits [15,16]. In their animal study on tracheal reconstruction with auricular cartilage grafts and HBO as an adjuvant, Gungor et al [14] found less inflammation, fibrosis, and necrosis, and earlier neovascularisation.…”

Section: Discussionmentioning

confidence: 96%

Effect of hyperbaric oxygen on survival of composite grafts in rats

Fodor

Ramon

Meilik

et al. 2006

Scandinavian Journal of Plastic and Reconstructive Surgery and

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Most treatment with hyperbaric oxygen (HBO) in plastic surgery is for wounds, burns, crush injuries, and infections. We aimed to find out if HBO increases the survival of composite grafts in rats. Twenty Sprague-Dawley rats were randomly assigned to two equal groups (treatment and control). A template 30 x 30 mm was placed on the skin and a composite graft taken from the upper back was harvested and then resutured to the fascia in situ. The treated group was placed in a hyperbaric chamber set at 202 kPa and 100% oxygen for 90 minutes daily for two weeks. Control animals were given no treatment. After death the mean surviving internal surface area of the graft was 372.5 (117.9) mm2 in the control group and 561.3 (85.7) mm2 in the experimental group (p=0.001). Treatment with HBO improved the surviving area of composite grafts in rats, and the beneficial effect was prominent only on the inner surface of the graft.

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Pilot Study to Evaluate the Efficacy of Hyperbaric Oxygen Therapy in Improving the Survival of Reattached Auricular Composite Grafts in the New Zealand White Rabbit

Cited by 19 publications

References 20 publications

An Evidence-Based Appraisal of the Use of Hyperbaric Oxygen on Flaps and Grafts

An Evidence-Based Appraisal of the Use of Hyperbaric Oxygen on Flaps and Grafts

The Effect of Hyperbaric Oxygen Therapy on Composite Graft Survival

Effect of hyperbaric oxygen on survival of composite grafts in rats

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