Pilot study to determine whether reduced-dose photon-counting detector chest computed tomography can reliably display Brody II score imaging findings for children with cystic fibrosis at radiation doses that approximate radiographs

Horst, Kelly K.; Hull, Nathan C.; Thacker, Paul G.; Demirel, Nadir; Yu, Lifeng; McDonald, Jennifer S.; Larson, Nicholas B.; McCollough, Cynthia H.; Fletcher, Joel G.

doi:10.1007/s00247-022-05574-6

Cited by 11 publications

(2 citation statements)

References 53 publications

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“…Die höhere räumliche Auflösung und das bessere Kontrast-Rausch-Verhältnis, verglichen mit EID, verbessern die Sichtbarkeit anatomischer Strukturen bei Kindern mit hoher Dosiseffizienz [ 33 ]. Durch diese höhere Dosiseffizienz wird eine diagnostische Umstellung von Röntgenaufnahmen hin zu Niedrig-Dosis CT ermöglicht [ 34 ].…”

Section: Hintergrundunclassified

CT technology: photon-counting detector computed tomography

Layer¹,

Kravchenko²,

Dell³

et al. 2023

Radiologie

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Hintergrund Die photonenzählende Computertomographie („photon-counting detector computed tomography“, PCD-CT) ist eine Technologie, die viele Einschränkungen der herkömmlichen Detektoren überwindet. Eine direkte Umwandlung der auf den Detektor eintreffenden Photonen in elektrische Signale, verbunden mit einer sensitiveren und präziseren Photonerfassung ermöglicht eine spektrale Auswertung sowie eine potenziell verringerte Strahlenexposition des Patienten. Durch die Kombination von angewandten Energieschwellenwerten und den Verzicht auf Detektorsepten kann elektronisches Rauschen reduziert, die Ortsauflösung erhöht und die Dosiseffizienz gesteigert werden. Bewertung Aktuelle Forschungsarbeiten bestätigen deutlich reduziertes Bildrauschen, reduzierte Strahlendosis, erhöhte Ortsauflösung, verbessertes Jodsignal sowie eine Reduktion von Artefakten. Die spektrale Auswertung potenziert diese Effekte und ermöglicht auch retrospektiv die Errechnung virtuell-monoenergetischer Bilder, virtuell-nativer Bilder oder Jodkarten. Perspektivisch ergibt sich durch die photonenzählende Technologie die Möglichkeit zur Anwendung diverser Kontrastmittel, mit der Aussicht auf einzeitige Mehrphasenbildgebung oder zur Visualisierung bestimmter Stoffwechselprozesse. Bis zum klinischen Einsatz sind hierzu weitere Grundlagenforschung sowie ergänzende Zulassungsprozesse notwendig. Schlussfolgerung Das bisher einzige am Markt verfügbare PCD-CT-Gerät erhielt 2021 die Zulassung. Es bleibt abzuwarten, welche weitere Anwendungen durch Verbesserungen von Hardware und Software möglich werden. Insbesondere für hochauflösende Bildgebung bei detaillierten Fragestellungen und Untersuchungen mit hoher Strahlenbelastung zeigt die Technologie bereits heute eine eindrucksvolle Überlegenheit gegenüber dem vorherigen Technologiestandard.

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Section: Hintergrundunclassified

CT technology: photon-counting detector computed tomography

Layer¹,

Kravchenko²,

Dell³

et al. 2023

Radiologie

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“…While several reports comparing the accuracy of VMI from PCD-CT to dual-energy CT and studies describing the clinical utility PCD-CT system can be found in the literature (Liu et al 2022, Allmendinger et al 2022, Hagen et al 2022, Rajendran et al 2022, Horst et al 2023, investigations evaluating the performance of the automatic VMI energy level selection tool, a vital component of the PCD-CT scanner for optimizing image quality and radiation dose, have not been reported thus far to the best of our knowledge. Furthermore, a parameter termed 'image quality (IQ) level' has been introduced on the clinical PCD-CT system for tube current modulation.…”

Section: Introductionmentioning

confidence: 99%

Task-based automatic keV selection: leveraging routine virtual monoenergetic imaging for dose reduction on clinical photon-counting detector CT^*

Rajendran,

Bruesewitz,

Swicklik

et al. 2024

Phys. Med. Biol.

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Objective: Photon-counting detector (PCD) CT enables routine virtual-monoenergetic image (VMI) reconstruction. We evaluated the performance of an automatic VMI energy level (keV) selection tool on a clinical PCD-CT system in comparison to an automatic tube potential (kV) selection tool from an energy-integrating-detector (EID) CT system from the same manufacturer. Approach: Four torso-shaped phantoms (20-50 cm width) containing iodine (2, 5, and 10-mg/cc) and calcium (100 mg/cc) were scanned on PCD-CT and EID-CT. Dose optimization techniques, task-based VMI energy level and tube-potential selection on PCD-CT (CARE keV) and task-based tube potential selection on EID-CT (CARE kV), were enabled. CT numbers, image noise, and dose-normalized contrast-to-noise ratio (CNRd) were compared. Main results: PCD-CT produced task-specific VMIs at 70, 65, 60, and 55 keV for non-contrast, bone, soft tissue with contrast, and vascular settings, respectively. A 120 kV tube potential was automatically selected on PCD-CT for all scans. In comparison, EID-CT used x-ray tube potentials from 80 kV to 150 kV based on imaging task and phantom size. PCD-CT achieved consistent dose reduction at 9%, 21% and 39% for bone, soft tissue with contrast, and vascular tasks relative to the non-contrast task, independent of phantom size. On EID-CT, dose reduction factor for contrast tasks relative to the non-contrast task ranged from a 65% decrease (vascular task, 70 kV, 20 cm phantom) to a 21% increase (soft tissue with contrast task, 150 kV, 50 cm phantom) due to size-specific tube potential adaptation. PCD-CT CNRd was equivalent to or higher than those of EID-CT for all tasks and phantom sizes, except for the vascular task with 20 cm phantom, where 70 kV EID-CT CNRd outperformed 55 keV PCD-CT images. Significance: PCD-CT produced more consistent CT numbers compared to EID-CT due to standardized VMI output, which greatly benefits standardization efforts and facilitates radiation dose reduction.

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Feasibility of photon-counting CT for femoroacetabular impingement syndrome evaluation: lower radiation dose and improved diagnostic confidence

et al. 2023

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Pilot study to determine whether reduced-dose photon-counting detector chest computed tomography can reliably display Brody II score imaging findings for children with cystic fibrosis at radiation doses that approximate radiographs

Cited by 11 publications

References 53 publications

CT technology: photon-counting detector computed tomography

CT technology: photon-counting detector computed tomography

Task-based automatic keV selection: leveraging routine virtual monoenergetic imaging for dose reduction on clinical photon-counting detector CT^*

Feasibility of photon-counting CT for femoroacetabular impingement syndrome evaluation: lower radiation dose and improved diagnostic confidence

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Pilot study to determine whether reduced-dose photon-counting detector chest computed tomography can reliably display Brody II score imaging findings for children with cystic fibrosis at radiation doses that approximate radiographs

Cited by 11 publications

References 53 publications

CT technology: photon-counting detector computed tomography

CT technology: photon-counting detector computed tomography

Task-based automatic keV selection: leveraging routine virtual monoenergetic imaging for dose reduction on clinical photon-counting detector CT *

Feasibility of photon-counting CT for femoroacetabular impingement syndrome evaluation: lower radiation dose and improved diagnostic confidence

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Task-based automatic keV selection: leveraging routine virtual monoenergetic imaging for dose reduction on clinical photon-counting detector CT^*