Pilot study on the perfluorooctanesulfonate and perfluorooctanoate exposure of the German general population

Midasch, O; Schettgen, Thomas; Angerer, Jürgen

doi:10.1016/j.ijheh.2006.06.002

Cited by 98 publications

(51 citation statements)

References 43 publications

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“…[32] Similarly, in a German pilot study the PFOS concentrations in male plasma were 430% higher than in female plasma, whereas the difference in PFOA concentrations was o10%. [50] Investigations on Chinese blood samples also confirmed these observations. [41] Two main explanations for this trend were assumed.…”

Section: Levels and Trends In Humansmentioning

confidence: 73%

Trends of polyfluoroalkyl compounds in marine biota and in humans

Sturm

Ahrens

2010

Environ. Chem.

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Environmental context. Polyfluoroalkyl compounds are used in a variety of industrial and consumer applications, including polymer production and for surface treatment of textiles and paper. Research over the last 10 years has shown that these compounds are ubiquitous environmental contaminants -they are extremely persistent, show toxic effects and accumulate in the food chain. We evaluate global, temporal and spatial trends of these important emerging contaminants.Abstract. This review gives an overview of existing knowledge of polyfluoroalkyl compounds (PFCs) in humans and in marine biota. Temporal trends and spatial distribution of PFCs were globally compared in humans, marine mammals, seabirds and fish. In general, PFC concentrations in the environment have increased significantly from the beginning of the production up to the 1990s. After the phase-out of perfluorooctane sulfonyl fluoride (POSF) production starting in 2000, PFC concentrations in humans generally decreased. In marine biota no clear temporal trends were observed. The temporal trends depended on the species, their trophic levels and the geographical locations. PFC patterns in humans and in marine wildlife species were compared regarding perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), their shorter and longer chain homologues (C 4 -C 15 ) and precursor compounds. Finally knowledge gaps were identified and recommendations for future work were presented.

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Section: Levels and Trends In Humansmentioning

confidence: 73%

Trends of polyfluoroalkyl compounds in marine biota and in humans

Sturm

Ahrens

2010

Environ. Chem.

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“…Half-lives of approximately 5 years (PFOS) and 4 years (PFOA) are reported (Olsen et al 2005). Due to their widespread use and their bioaccumulative properties PFOS and PFOA can be detected in serum samples of the general population around the world (Calafat et al 2005;Fromme et al 2006;Guruge et al 2005;Harada et al 2004;Inoue et al 2004;Kannan et al 2004;Kärrman 2004;Kubwabo et al 2004;Kuklenyik et al 2004;Midasch et al 2006;Olsen et al 2003aOlsen et al , b, 2004UBA 2004;Yeung et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study

Midasch

Drexler

Hart

et al. 2007

Int Arch Occup Environ Health

245

154

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For both substances a crossing of the placental barrier could be shown. For PFOS we observed a decrease from maternal to cord plasma concentrations by a factor of 0.41-0.80. To the contrary, PFOA crosses the placental barrier obviously unhindered. These findings show that neonates are exposed to PFOS and PFOA via their mothers' blood. Given the current situation that only little is known about the consequences of PFOS and PFOA exposure in the early state of development of humans and the fact that in animal studies both substances showed developmental toxic effects further research regarding human health effects is indispensable.

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“…8 Inoue et al 18 were the first to report the presence of PFCs in human maternal and cord blood samples, and several other studies followed. [19][20][21] Furthermore, recent epidemiological studies in Denmark, USA and Japan [21][22][23] have investigated possible adverse effects of PFCs on the foetus. In the Danish cohort they found an inverse association between maternal PFOA concentration and birth weight.…”

mentioning

confidence: 99%

Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study

et al. 2010

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There is limited information about both environmental and human perfluorinated compounds (PFCs) concentrations in the southern hemisphere, and for the first time, concentrations of these compounds are reported in maternal serum and cord blood of South African women. The majority of the participants were of African Black ethnicity, with a similar socioeconomic status. In maternal serum perfluorooctane sulfonate (PFOS) was found to be the most abundant PFC (1.6 ng mL ) and perfluorohexane sulfonate (PFHxS: 0.5 ng mL À1 ); however, in cord blood PFOA was the most abundant compound (1.3 ng mL À1) followed by PFOS (0.7 ng mL À1) and PFHxS (0.3 ng mL À1). Linear PFOS constituted 58% of the sum of PFOS, comparable with a reported percentage from Australia. Differences in PFC concentrations between communities were found, with the highest concentrations in urban and semi-urban areas. The median maternal PFOS concentration was lower than has been reported in other studies, whereas the PFOA concentration was the same. This clearly indicates that the exposure pathway is different from the western world. Significant differences in housing quality were observed and the urban and sub-urban community had the highest living and housing standards. Possible exposure pathways could be different from those elucidated in the western world with the exception of the urban community in our study that showed higher living standards in general and easier access to modern consumer products.

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Pilot study on the perfluorooctanesulfonate and perfluorooctanoate exposure of the German general population

Cited by 98 publications

References 43 publications

Trends of polyfluoroalkyl compounds in marine biota and in humans

Trends of polyfluoroalkyl compounds in marine biota and in humans

Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study

Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study

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