Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia

Abstract

Introduction: The hemoglobinopathies are a heterogeneous group of congenital anemias from Africa, Asia and the Medi­terranean. Due to the migration of this population have spread worldwide, especially in Latin America and the Caribbean region, which Cartagena de Indias is included, with a large proportion of people of African descent. The lack of routine programs that include an appropriate methodology for precise identification of those affected and carriers, impossible to know the real behavior of this disease in our country and an early and appropriate to the patients before the disease mani­fests itself and produce its serious consequences. Objective: To estimate the incidence and describe the epidemiological profile of hemoglobinopathies in newborns Rafael Calvo Maternity Clinic of Cartagena, in the period from January to June 2010. Methods: Prospective descriptive study of a population of 1729 newborns. Samples were collected cord blood on filter paper. Isoelectric focusing electrophoresis (IEF )was used to separate the haemoglobins. Results: 94.4% (1633samples) were normal (hemoglobinFA), 4.5% (78samples) were heterozygous for haemoglobin S (HbFAS), 1% (17samples) were heterozygous for haemoglobin C (hemoglobinFAC) and 0.1% (1 sample) was double hete­rozygous SC (hemoglobinFSC). Conclusion: Due to the high incidence of hemoglobinopathies found in this pilot study highlights the importance and necessity of establishing an obligatory neonatal screening in the city of Cartagena, in order to make a timely diagnosis and monitoring of affected and carrier.

Deficiencia de glucosa-6-fosfato-deshidrogenasa (G6PD) en individuos de la ciudad de Cartagena

“…Adicionalmente, esta frecuencia de 4,6% de deficientes de G6PD resulta similar al 4,7% descrito por Alvear y col para la presencia de rasgo falciforme en una muestra de 1729 recién nacidos en el periodo de enero a junio de 2019 en Cartagena de Indias (17). Frecuencias que están por encima de los 0,07 casos por 100.000 personas en 2016 y de los 0,32 casos en 2017, que reporta el Instituto Nacional de Salud para la prevalencia nacional de drepanocitosis (18).…”

Importance of early detection of hemoglobinopathies in the pediatric population in developing countries

“…Las tendencias migratorias mundiales han cambiado la epidemiología de las hemoglobinopatías. Los trastornos de Hb se originaron en África, Asia y la cuenca mediterránea, y se han distribuido en todo el mundo debido a la migración de estos grupos de población 12 . Esto ha provocado un cambio en el panorama demográfico y ha aumentado la aparición de esta condición en áreas donde la prevalencia es baja como en América del Norte y Europa 13 .…”

Sickle Cell Trait Induces Oxidative Damage on Plasmodium falciparum Proteome at Erythrocyte Stages

“…For this, donors with 36.4–43.0% of HbAS were identified by horizontal hemoglobin electrophoresis. A 6% prevalence was calculated in our random sample, establishing in the range of 5–10% reported for some regions of the Colombian territory [20,21]. Next, parasites were cultured and processed to obtain proteomes at ring, trophozoites and schizonts stages.…”