Pilot Study Examining the Effects of Atropine on Performance during Uncompensable Heat Stress

Suyama, Joe; McEntire, Serina J.; Rittenberger, Jon C.; Rosalky, Deena S.; Reis, Steven E.; Hostler, David

doi:10.3109/10903127.2015.1076092

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…eliminate sudomotor responses to non-thermal stimuli(Machado-Moreira et al, 2012;Suyama et al, 2016) Thus, ACh receptors located on eccrine seat glands are not been copyedited and formatted.…”

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confidence: 99%

Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

et al. 2023

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Pharmacological agents used to treat or manage diseases can modify the level of heat strain experienced by chronically ill and elderly patients via different mechanistic pathways. Human thermoregulation is a crucial homeostatic process that maintains body temperature within a narrow range during heat stress through dry (i.e., increasing skin blood flow) and evaporative (i.e., sweating) heat loss, as well as active inhibition of thermogenesis, which is crucial to avoid overheating.Medications can independently and synergistically interact with ageing and chronic disease to alter homeostatic responses to rising body temperature during heat stress. This review focuses on the physiological changes, with specific emphasis on thermolytic processes, associated with medication use during heat stress. The review begins by providing readers with a background of the global chronic disease burden. Human thermoregulation and ageing effects are then summarised to give an understanding of the unique physiological changes faced by older adults. The effects of common chronic diseases on temperature regulation are outlined in the main sections. Physiological impacts of common medications used to treat these diseases are reviewed in detail, with emphasis on the mechanisms by which these medications alter thermolysis during heat stress. The review concludes by providing perspectives on the need to understand the effects of medication use in hot environments, as well as a summary table of all clinical considerations and research needs of the medications included in this review.

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confidence: 99%

Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

et al. 2023

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“…Atropine concomitantly increases blood flow in skin, and this anticholinergic agent can reduce sweating by approximately 45% . Atropine given via the intramuscular route tends to increase the heart rate, suppress weakness and hypotension, and inhibit the increase in gastric emptying during hypoglycaemia in humans and rats…”

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confidence: 99%

Use of atropine in four‐dimensional hysterosalpingo‐contrast sonography: Does it suppress pain during infertility examination?

et al. 2018

Clin Exp Pharma Physio

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This study aimed to ascertain if atropine is useful for suppressing the pain suffered during four-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy) when assessing infertility in women. A total of 252 patients were divided into 2 groups to receive or not receive atropine (0.5 mg) injection 30 minutes before 4D-HyCoSy. Pain was evaluated using a numerical rating scale (NRS): during 4D-HyCoSy; upon 2-dimensional transvaginal sonography; before catheter insertion; upon insertion and fixation of the catheter into the uterine cavity; 30 minutes after 4D-HyCoSy. According to the degree of patency of Fallopian tubes, the 6 patterns observed were integrated further into 3 patient groups: all-negative (both Fallopian tubes were negative), positive-and-negative (one Fallopian tube showed patency and the other showed stenosis or non-patency), and all-positive (both Fallopian tubes showed stenosis or non-patency). We compared the NRS scores and prevalence of side-effects other than pain between the atropine-injection and non-atropine-injection groups within the three groups mentioned above. The NRS score showed no significant differences among the groups at any time point (all P > .05). The different prevalence of side-effects other than pain was significant between the atropine-injection and atropine-non-injection groups (P = .012). These data suggest that atropine does not reduce pain in patients during 4D-HyCoSy. However, atropine may reduce the prevalence of other side-effects during 4D-HyCoSy, which needs a further, large, prospective, multi-cohort study to verify.

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Pilot Study Examining the Effects of Atropine on Performance during Uncompensable Heat Stress

Abstract: thermoregulation; cholinolytic; anticholinergic; reaction time.

Cited by 2 publications

References 15 publications

Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

Use of atropine in four‐dimensional hysterosalpingo‐contrast sonography: Does it suppress pain during infertility examination?

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