Pilot Study Evaluating Physical Activity and Fatigue in Adolescent Oncology Patients and Survivors During Summer Camp

Withycombe, Janice S.; Baek, Min Joo; Jordan, Dorothy; Thomas, Nimmy J.; Hale, Sally

doi:10.1089/jayao.2017.0074

Cited by 10 publications

(3 citation statements)

References 25 publications

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“…Our comparison of movement behaviours indicators revealed a significant difference in LPA during SW, with the girls accumulating more minutes of PA of light intensity than the boys. This finding is in contrast with the results published previously ( 16 , 22 ), which showed higher levels of PA rather in boys.…”

Section: Discussioncontrasting

confidence: 99%

“…Less attention was paid to the influence of recovery camps on movement behaviours. Self-reported data suggest that the camps may temporarily contribute to an increase in PA levels ( 22 , 23 ). However, there are no known studies which have examined movement behaviours of PCS objectively during recovery camps and the following habitual school weeks.…”

Section: Introductionmentioning

confidence: 99%

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Movement behaviours in paediatric cancer survivors during recovery and school weeks

Vyhlídal

Dygrýn²,

Pelclová³

et al. 2022

Front. Oncol.

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PurposePaediatric cancer survivors (PCS) are a high-risk population, who can suffer from late effects of their treatment, such as metabolic syndrome, cardiovascular conditions, secondary tumours. Optimal movement behaviours (e.g., limited sedentary behaviour [SB] and sufficient physical activity [PA]) can reduce the side effects or avoid late effects of their treatment. The aims of this study were to analyse movement behaviours and meeting the recommendation of 60 minutes of moderate-to-vigorous physical activity (MVPA) a day in Czech PCS, and to compare their movement behaviours during recovery and school weeks in relation to gender, age, and cancer type.MethodsTwenty-six PCS aged 7-15 years in remission stage took part in the cross-sectional study. Movement behaviours were measured with Actigraph wGT3X+ accelerometers worn 24 hour/day for 20 consecutive days covering recovery week (13 days at recovery camp) and school week (7 days). Based on cancer types, the PCS were categorized into haematological malignancy or solid tumours group.ResultsIn the PCS, movement behaviours differed between recovery and school weeks. During recovery week, the PCS showed less SB (451.8 vs. 552.3 min/day, p < 0.001) and spent more time on light PA (350.3 vs. 255.1 min/day, p < 0.001), moderate PA (73.2 vs. 37.4 min/day, p < 0.001), and vigorous PA (10.3 vs. 4.0 min/day p < 0.001) than during school week. The PA recommendation was met by 77% (n = 20) PCS during recovery week, but only by 15% (n = 4) individuals during school week.ConclusionsThe PCS recorded higher levels of PA and lower levels of SB during recovery week than during school week. If provided with appropriate conditions, PCS in the remission stage are able to reach the PA level recommended for the healthy population. Recovery week can be a suitable platform for gaining experience that PCS are able to meet the recommended PA level and could be an integral part of reconditioning and resocialization programmes for PCS after the completion of their treatment.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Movement behaviours in paediatric cancer survivors during recovery and school weeks

Vyhlídal

Dygrýn²,

Pelclová³

et al. 2022

Front. Oncol.

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“…Physical activity, a broad term that includes movement activities such as structured exercise, walking, and yoga, has been associated with reduced cancer-related fatigue in both adults and, to a lesser degree, children (Hilfiker et al, 2018; Huang et al, 2019; Huang & Ness, 2011; Tomlinson et al, 2014; Withycombe et al, 2018). The biological explanation for the relationship between fatigue and physical activity may be explained, in part, by cytokine gene expression changes that reduce inflammation, mind–body interactions that decrease cortisol levels, and maintenance of muscle mass which assists with production of ATP (Kinney et al, 2019); However, the precise biological connections between fatigue and physical activity during and after childhood cancer therapy are still relatively unknown.…”

mentioning

confidence: 99%

Metabolites Associated With Fatigue and Physical Activity in Childhood Cancer

Withycombe

Eldridge

Jin

et al. 2022

Biological Research For Nursing

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Introduction: Children and adolescents with cancer report increased fatigue and decreased physical activity, introducing risk factors for chronic disease and suppressed quality of life. Research suggests an inverse relationship between fatigue and physical activity, but the biological explanation is not well understood. The purpose of this study was to 1) explore metabolites associated with fatigue or physical activity and 2) to identify any shared metabolomic elements. Methods: Children, ages 8–17 years, attending a pediatric oncology summer camp provided Patient-Reported Outcome Measurement System® (PROMIS) Pediatric Fatigue assessments, physical activity data (steps/day), and urine samples pre- and post-camp. Differences in PROMIS Pediatric Fatigue scores and average daily steps were calculated using paired t-tests. Liquid chromatography-tandem mass spectrometry was conducted using a targeted metabolomic approach. Results: Thirty-two enrolled children had complete data. Fatigue scores decreased (pre-camp 45.1; post-camp 42.1; p = 0.04) while steps-per-day increased (pre-camp 6699; post-camp 16,021; p < 0.001). Twenty-seven metabolites significantly differentiated (false discovery rate <0.20) between low, medium, or high physical activity, while 8 metabolites discriminated between high and low fatigue. Indole-3-lactic acid, a tryptophan metabolite, was significantly associated with both physical activity and fatigue. Conclusion: This study provides evidence of metabolome associations with fatigue and physical activity in children with cancer. Overlapping metabolomic elements provide evidence of biological inter-connectivity and suggest areas for future research. Given the known evidence regarding the benefits of physical activity, and the potential interaction with fatigue, nurses should routinely assess patient reports of these elements and provide patient/family education related to fatigue management and physical activity goals.

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Severe fatigue after treatment for childhood cancer

Deuren

Boonstra

Broeder

et al. 2020

Cochrane Database of Systematic Reviews

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BackgroundTreatment strategies for childhood cancer are improving, resulting in higher survival rates. However, the consequences of childhood cancer do not end with the successful completion of cancer treatment. Most patients will develop late e ects a er cessation of treatment. Severe fatigue is seen as a common and debilitating late e ect in cancer survivors. Although most research on fatigue has been performed in patients a er adult-onset cancer, our review focuses on fatigue a er childhood cancer. ObjectivesTo estimate the prevalence of severe fatigue a er treatment for childhood cancer. Secondary objectives are to describe the course of severe fatigue following cancer treatment and to examine risk factors for fatigue, or factors associated with it.Severe fatigue a er treatment for childhood cancer (Review)

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Pilot Study Evaluating Physical Activity and Fatigue in Adolescent Oncology Patients and Survivors During Summer Camp

Cited by 10 publications

References 25 publications

Movement behaviours in paediatric cancer survivors during recovery and school weeks

Movement behaviours in paediatric cancer survivors during recovery and school weeks

Metabolites Associated With Fatigue and Physical Activity in Childhood Cancer

Severe fatigue after treatment for childhood cancer

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