Pilot study evaluating inhalation and dermal glyphosate exposure resulting from simulated heavy residential consumer application of Roundup^®

Risk Assessment of Glyphosate Exposures from Pilot Study with Simulated Heavy Residential Consumer Application of Roundup® using a Margin of Safety (MOS) Approach

“…As had been previously reported, urinary glyphosate, AMPA, and “effective glyphosate” concentrations across the applicators followed similar temporal trajectories with concentrations generally peaking at three hours or six hours postapplication and returning to preapplication concentrations by 24 hours postapplication (see Pierce et al., 2020).…”

“…In comparison to the 11 identified studies with occupational application‐related exposures, though exposure duration and sampling time after application varies across the studies, the current study includes urinary glyphosate data from applicators simulating heavy residential consumer application in Pierce et al. (2020) that is similar to or in most circumstances greater than those in occupational applicators. In particular, while this study has the highest reported urinary glyphosate concentration of 310.9 μg/L following the application of a glyphosate‐based herbicide (Pierce et al., 2020), only one of the 11 studies on occupational application‐related exposures has relatively higher urinary glyphosate concentrations: Acquavella et al.…”

“…An IRB‐approved biomonitoring study involving the collection of individual urinary void spot samples was completed and previously reported (Pierce et al., 2020). In brief, the study was conducted during a single day in July of 2019 in a gravel and asphalt yard in Monee, IL.…”

“…While the general population may be exposed to glyphosate in the air and in foods and drinking water, these environmental and dietary exposures are considered low in comparison to exposures that may occur during application of glyphosate‐containing herbicides (ATSDR, 2019). To date only one pilot study, which we recently conducted, has characterized exposures to glyphosate following simulated heavy residential consumer application of a glyphosate‐containing herbicide (see Pierce et al., 2020). In this previous study, we demonstrated that urinary glyphosate concentrations in these applicators generally peaked within six hours following application and were similar to or in some circumstances greater than those in occupational applicators, likely due to the nature of the simulation study, which ensured a heavy application protocol.…”

Chimeric Antigen Receptor T-cell Therapy for Multiple Myeloma

“…New studies of amenity horticulturists using GBFs for recreational or ornamental purposes found urine levels similar to those seen in farmers 7,8 . In a recent pilot study 9 evaluating inhalation and dermal exposures resulting from simulated heavy residential consumer application of Roundup, urinary glyphosate levels were elevated in all applicators and usually peaked within six hours following application, but were usually similar to background levels at 24 hours post application. Peak urinary glyphosate levels ranged from 5.55 -310.91 µg/L (ppb) in the dermal exposure group, and from 3.79-17.23 µg/L in the inhalation group.…”