Pilot series of radiofrequency ablation of Barrett’s esophagus with or without neoplasia

Abstract

In this study, Barrett's eradication rates were comparable to previously published reports. One case of buried Barrett's metaplasia was identified out of 247 biopsies and was eradicated with repeat ablation.

How Good Is the Neosquamous Epithelium?

“…For instance, one report of a large (127 patients) multicenter, prospective, sham-controlled randomized trial of radiofrequency ablation for dysplastic (low-/high-grade) BE [20] showed successful ablation and reepithelialization by NSE in 77%, with a 2% serious complication rate and no deaths. This and earlier favorable reports explain the growing popularity of radiofrequency ablation and its expanding utilization from high- to low-grade dysplasia and, more recently, to Barrett's metaplasia [8,21,22,23]. …”

A systematic review of the evidence for radiofrequency ablation for Barrett’s esophagus

“…In the end, nine studies (11 publications) with usable information, all published between 2007 and 2009, were included in our systematic review. Five of the studies (six publications [9,10,12,[17][18][19] [11,20,21]) examined patients who had Barrett's esophagus but without limitation, and one study (two publications [22,23]) examined patients with Barrett's esophagus containing intestinal metaplasia but no dysplasia. In six of the included studies, EMR was conducted before ablation in case of endoscopically visible abnormalities or nodules [9][10][11][17][18][19][20].…”

“…Radiofrequency ablation with the HALO system (BÂ RRX Medical Inc., Sunnyvale, CA), a new and promising option for treating Barrett's esophagus, has top actuality and initial results from case reports and mainly small studies recently have been published extensively in endoscopic journals [7][8][9][10][11][12][13]. Thus, RFA may provide a more efficient mode of treatment for intraepithelial dysplasia than other endoscopic options such as photodynamic therapy or Argon plasma coagulation, which have resulted in a high stricture rate and the formation of buried glands (''buried Barrett'') [14][15][16].…”

Diagnosis and Management of Barrett’s Esophagus with and Without Dysplasia

“…The results of these studies showed that eradication rate of IM, any dysplasia, including also HGD was in 46%-100%, and 71%-100% respectively. [230,232,[234][235][236][237][238][239][240]. In one study 44 patients with LGD, HGD, or IMC treated with RFA (31 patients had prior EMR for visible lesions before RFA) were evaluated [237].…”