Mining often results in the contamination of groundwater by metal, sulphate and radionuclide ions following their percolation from tailings impoundments. This chapter discusses the processes by which elements within tailings are transformed and translocated to groundwater and the role of aquifer characteristics and colloids in these processes. The prevention and remediation of contaminated groundwater is also discussed, with particular attention given to the use of permeable reactive barriers and sulphate reducing bacteria.