Pilot of Three Objective Markers of Physical Health and Chemotherapy Toxicity in Older Adults

Hsu, Tina; Chen, R.; Lin, Stephanie; Djalalov, Sarvar; Horgan, Anne M.; Le, Lisa W.; Leighl, Natasha B.

doi:10.3747/co.22.2623

Cited by 12 publications

(16 citation statements)

References 43 publications

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“…Sample sizes ranged from 24 [39] to 12,979 [52]. Studies were globally represented; 24 studies from Asia [40-43, 46-48, 50, 53-56, 58-66, 68, 70], 14 from Europe [31-36, 38, 44, 45, 51, 57, 69, 71, 72], and 5 from North America [37,39,49,52,67].…”

Section: Resultsmentioning

confidence: 99%

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis

et al. 2020

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Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer are a complex, growing population at high risk of weight-losing conditions. A number of malnutrition screening tools exist, however the best screening tool for this group is unknown. The aim was to systematically review the published evidence regarding markers and measures of nutritional status in older adults with cancer (age ≥ 70). A systematic search was performed in Ovid Medline, EMBASE, Web of Science, CINAHL, British Nursing Database and Cochrane CENTRAL; search terms related to malnutrition, cancer, older adults. Titles, abstracts and papers were screened and quality-appraised. Data evaluating ability of markers of nutritional status to predict patient outcomes were subjected to meta-analysis or narrative synthesis. Forty-two studies, describing 15 markers were included. Meta-analysis found decreased food intake was associated with mortality (OR 2.15 [2.03–4.20] p = < 0.00001) in univariate analysis. Prognostic Nutritional Index (PNI) was associated with overall survival (HR 1.89 [1.03–3.48] p = 0.04). PNI markers (albumin, total lymphocyte count) could be seen as markers of inflammation rather than nutrition. There a suggested relationship between very low body mass index (BMI) (<18 kg/m2) and clinical outcomes. No tool was identified as appropriate to screen for malnutrition, as distinct from inflammatory causes of weight-loss. Risk of cancer-cachexia and sarcopenia in older adults with cancer limits the tools analysed. Measures of food intake predicted mortality and should be included in clinical enquiry. A screening tool that distinguishes between malnutrition, cachexia and sarcopenia in older adults with cancer is needed.

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Section: Resultsmentioning

confidence: 99%

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis

et al. 2020

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“…Characteristics of included studies are presented in Table 1 . Eighteen studies were prospective cohort studies [24][25][26][27][28][29][30][31][32][33][34][35]38,41,43,[45][46][47][48][49]51,52], and nine were retrospective studies [36,37,39,40,42,44,50,51,53].…”

Section: Resultsmentioning

confidence: 99%

“…Mobility problems (i.e. walking impairment, and inability to walk more than one block) was associated with chemotherapy toxicity in two out of four studies [29,41]. Three out of nine studies [31,35,37] reported that having severe comorbid conditions was associated with chemotherapy toxicity.…”

Section: Chemotherapy Toxicitymentioning

confidence: 96%

“…The results regarding chemotherapy toxicity grade 3 to 5 are presented in Table 2 [28,29,31,32,[36][37][38]40,41,[43][44][45][46]48,[51][52][53].…”

Section: Chemotherapy Toxicitymentioning

confidence: 99%

“…The results regarding not completing the planned number of chemotherapy cycles are reported in 13 studies and listed in Table 3 [26,30,31,35,36,[39][40][41][42]44,49,50,52].…”

Section: Chemotherapy Discontinuationmentioning

confidence: 99%

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Patient- and tumor-related predictors of chemotherapy intolerance in older patients with cancer: A systematic review

Abbema

Akker

Janssen‐Heijnen

et al. 2019

Journal of Geriatric Oncology

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Physical and functional evaluations in oncological patients elective to medium and large operations

Vieira

Machado

Faria

et al. 2023

Support Care Cancer

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Purpose: To evaluate the physical and functional capacity and the risk of sarcopenia on the length of hospital stay and deaths in preoperative cancer patients. Methods: Preoperative patients admitted to the Cancer Hospital of Mato Grosso comprised the sample. Sociodemographic data, lifestyle data, and a questionnaire for sarcopenia screening were collected. Subsequently, total body mass, height, muscle strength, muscle mass, and physical performance were evaluated. The data were tabulated and analyzed using the statistical software SPSS (25.0). The signi cance level was 5%. Results: We observed 12 (7.4%) patients with low muscle strength, 20 (12.3%) patients with low muscle mass, 11 (6.8%) patients with low physical performance, and 18 (11.1%) patients with scores for possible sarcopenia. When the risk of sarcopenia was observed, 44 (27.2%) patients had at least one risk related to muscle disorder. When analyzing the prevalence and association of sarcopenia with sociodemographic variables, we observed that education level was associated with sarcopenia (p = 0.031). In addition, there was an association between preoperative sarcopenia and postoperative death (p = 0.006). Finally, there were important correlations between muscle strength and physical performance (p <0.05), between muscle strength and the sarcopenia questionnaire (p <0.001), and between physical performance and the sarcopenia questionnaire (p <0.05). Conclusion: The results suggest the need for counseling and the need to evaluate patients for risk of sarcopenia, since early intervention, such as dietary supplementation and physical exercise, may favor a better postoperative prognosis, possibly corresponding to shorter hospital stays and longer survival and quality of life for patients, especially those who will undergo surgical procedures.

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Pilot of Three Objective Markers of Physical Health and Chemotherapy Toxicity in Older Adults

Abstract: Background Patient function is a key part of the clinical decision to offer chemotherapy and has, in earlier studies,

Cited by 12 publications

References 43 publications

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis

Patient- and tumor-related predictors of chemotherapy intolerance in older patients with cancer: A systematic review

Physical and functional evaluations in oncological patients elective to medium and large operations

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