BACKGROUND Opioids have been the mainstay of cancer pain relief for the past 40 years, but a multidimensional, biopsychosocial approach to assessment and treatment is now recommended. 1 The intensity of cancer pain and the distress it causes are well known, but it is less clear what patients with cancer think about their pain and how they cope with it. The electronic Persistent Pain Outcomes Collaboration (ePPOC) is an integrated pain outcomes center established in Australia and New Zealand (ANZ) in 2013 to standardize data collection from patients attending outpatient pain clinics. Before their first clinic visit, patients self-report their demographics, clinical status (pain history, including a checklist for how they think their pain began; comorbidities; medications; health care utilization), and responses to four validated questionnaires-Brief Pain Inventory short form (BPI-SF), Depression Anxiety Stress Scales-21 (DASS-21), Pain Self-Efficacy Questionnaire (PSEQ), and Pain Catastrophizing Scale (PCS). The aim of this study was to interrogate the ePPOC dataset to determine (1) pain intensity, pain interference, mood, and pain cognitions in patients with cancer-related pain (CRP), (2) how these data compare to those in patients with chronic non-cancer pain, and (3) whether demographic or clinical variables predict self-efficacy and catastrophizing in patients with CRP. 2 | METHODS 2.1 | Participants Ambulatory patients with chronic pain attending specialist pain clinics participating in the ePPOC initiative between June 2013 and December 2016 and who completed the pre-consultation questionnaire were included. Patients were identified as having CRP if they selected "related to cancer" from the how-pain-began checklist. The study was approved by the University of Sydney Human Research Ethics Committee. 2.2 | Questionnaires and their categorization Patients self-reported responses to the following questionnaires: • BPI-SF: assesses pain intensity and interference with activity and enjoyment of life in the past week. Clinically relevant cut-points for patients with cancer are 0 to 4 for mild, 5 to 6 for moderate and 7 to 10 for severe. 2 • DASS-21: assesses severity of depression, anxiety, and stress over the past week. For each subscale, scores are classified either as normal (0-9 for depression, 0-7 for anxiety, 0-14 for stress), mild (10-13 for depression, 8-9 for anxiety, 15-18 for stress), moderate (14-20 for depression, 10-14 for anxiety, 19-25 for stress), severe (21-27 for depression, 15-19 for anxiety, 26-33 for stress), or extremely severe (≥28 for depression, ≥20 for anxiety, ≥34 for stress). 3 • PSEQ: assesses how strongly the patient believes he or she can perform a range of activities despite pain. Lower scores indicate less confidence to perform. In this study, self-efficacy was categorized as 0 to 19 for severe, 20 to 30 for moderate, 31 to 40 for mild, ≥41 for minimal. 4 • PCS assesses helplessness, magnification, and rumination in relation to pain, higher scores being worse. The cut points used ...