Pilonidal Sinus Carcinoma dying from Squamous Cell Carcinoma within 14 months after Diagnosis.

Dettmer, Marius; Bonni, M.; Degiannis, Konstantinos; Maak, Matthias; Doll, Dietrich; Iesalnieks, Igors

doi:10.32391/ajtes.v6i1.255

Cited by 3 publications

(7 citation statements)

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“…Concerning the cases reported from Germany, only six patients were found over the study interval: two old cases published before 1940 [ 1 , 10 ], two cases that were published recently [ 11 , 12 ], and the two non-documented cases that were found through direct communication as mentioned above.…”

Section: Resultsmentioning

confidence: 99%

Demographic overview of pilonidal sinus carcinoma: updated insights into the incidence

Safadi

Dettmer

Berger³

et al. 2023

Int J Colorectal Dis

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Purpose There are only rough estimates of the worldwide incidence of pilonidal sinus carcinoma. The purpose of the study is to explore the demographic characteristics of this disease and to provide more precise information about its incidence. Methods The study included questioning the surgeons and pathologists in Germany in addition to a literature research. The literature investigation included all published articles about pilonidal carcinoma in all languages. The questionnaire included 1050 pathologists and all 834 hospitals with a surgical division in Germany. The outcome measures included the total number of cases, the language of publication, gender, age, country of origin, interval until the diagnosis of carcinoma, and reported incidence based on local studies. Results From 1900 to 2022, we found 140 cases of pilonidal sinus carcinoma in 103 articles. The investigation revealed two additional unpublished cases from Germany. The male-to-female ratio was 7.75:1. The countries with the most cases were the USA (35 cases, 25.0%), Spain (13 cases, 9.3%), and Turkey (11 cases, 7.6%). The average age was 54.0 ± 11.8 years and the interval between the diagnosis of the disease and the development of carcinoma was 20.1 ± 14.1 years. There was a parallel increase in reported cases of pilonidal sinus disease and pilonidal carcinoma over the last century. The reported incidence varied from 0.03% to 5.56%. The worldwide calculated incidence equaled 0.17%. Conclusion Due to underreporting and other causes, the incidence of carcinoma emerging on the background of pilonidal sinus disease is higher than reported.

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Section: Resultsmentioning

confidence: 99%

Demographic overview of pilonidal sinus carcinoma: updated insights into the incidence

Safadi

Dettmer

Berger³

et al. 2023

Int J Colorectal Dis

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Section: Discussionmentioning

confidence: 99%

“…The preformed fistula tracts, where carcinogenesis occurs, may serve as a pathway for local and systemic metastases. 11,19 The continuous shear forces through local pressure and friction in the sacral and gluteal region during walking can drive the tumor cells to leave their site of origin and disseminate more quickly, the same concept that underlies the principle of "no-touch technique" in oncologic surgery. 20 Surprisingly, our study showed no benefit of adjuvant treatment in PSDCA.…”

Section: Discussionmentioning

confidence: 99%

“…Although the locally or systemically advanced disease is already considered a poor prognostic factor in PSDCA, 7,11 the results regarding tumor grade were sometimes biased because of the small sample size. Some authors found no association between tumor differentiation and survival, calling this an “unexpected finding.” 12 In our study, long‐term survival in the G1‐group (47.0%, analysis of the only 54 patients with available grade data) was less than the overall 5‐year survival (53.6%, analysis of all 111 patients).…”

Section: Discussionmentioning

confidence: 99%

“…Further particular anatomical and mechanical factors may also contribute to the ability of these tumors to disseminate. The preformed fistula tracts, where carcinogenesis occurs, may serve as a pathway for local and systemic metastases 11,19 . The continuous shear forces through local pressure and friction in the sacral and gluteal region during walking can drive the tumor cells to leave their site of origin and disseminate more quickly, the same concept that underlies the principle of “no‐touch technique” in oncologic surgery 20 …”

Section: Discussionmentioning

confidence: 99%

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Pilonidal sinus disease carcinoma: Survival and recurrence analysis

Safadi

Degiannis

Doll

2023

Journal of Surgical Oncology

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BackgroundThe study aims to determine the survival and recurrence rates of pilonidal sinus disease (PSD) carcinoma.MethodsThe data were collected retrospectively by searching the worldwide literature for all reports of carcinoma developing on the background of PSD. The results were presented using Kaplan–Meier curves.ResultsBetween 1900 and 2022, 140 cases of PSD carcinoma were published in 103 papers, with follow‐up data available in 111 cases. Squamous cell carcinoma constituted 94.6% of the cases (n = 105). The disease‐specific survival rate was 61.7% for 3 years, 59.8% for 5 years, and 53.2% for 10 years. There was a significant survival difference between stages: 80.0% in stages I and II, 70.8% in stage III, and 47.8% in stage IV (p = 0.01). The 5‐year survival in G1‐tumors was better than G2 and G3‐tumors at 70.5% and 32.0%, respectively (p = 0.002). Recurrence occurred in 46.6% of the patients. The time‐to‐recurrence in patients treated with curative intention averaged 15.1 months (1–132 months). Local, regional, and distant recurrence was observed in 75.6%, 33.3%, and 28.9% of the recurrent tumors, respectively.ConclusionsPilonidal sinus carcinoma has a worse prognosis than primary cutaneous squamous cell carcinoma. Poor prognostic factors include advanced‐stage disease and poor differentiation.

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Treatment of metastatic squamous cell carcinoma arising in sacrococcygeal pilonidal sinus: a case report series

Soria Rivas,

Bea-Ardebol,

Vida Navas

et al. 2023

Front. Med.

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BackgroundSquamous cell carcinoma (SCC) arising in a sacrococcygeal pilonidal sinus is rare, with cases of metastatic disease being even rarer. Among published cases, almost none have reported on systemic treatment.ObjectiveThis disease has a poorer prognosis than other forms of cutaneous SCC; therefore, our objective is to shed some light on the treatment of metastatic disease.MethodsWe present a series of nine cases treated at a single center, four of whom received systemic treatment. Additionally, other previously reported cases of metastatic disease are included in an attempt to draw stronger conclusions.ResultsFour patients were treated under several treatment regimens, with a median progression-free survival of only 2 months and two instances of partial response (18%). The best result was achieved with cemiplimab. Across all the cases, there was a trend toward a benefit of the use of systemic treatment (HR 0.41, 95% CI 0.15–1.12, p = 0.083; median overall survival 13 vs. 8 months).LimitationsLimitations include the significant lack of information on previously published cases and the extremely heterogeneous nature of the existing information.ConclusionThe initial systemic treatment should be an anti-PD-1, as with other SCCs. After progression on anti-PD-1, there is no strong evidence to support the recommendation of a specific treatment or sequence: options include cetuximab and/or chemotherapy (platinum, paclitaxel, 5-fluorouracyl).

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Pilonidal Sinus Carcinoma dying from Squamous Cell Carcinoma within 14 months after Diagnosis.

Cited by 3 publications

References 7 publications

Demographic overview of pilonidal sinus carcinoma: updated insights into the incidence

Demographic overview of pilonidal sinus carcinoma: updated insights into the incidence

Pilonidal sinus disease carcinoma: Survival and recurrence analysis

Treatment of metastatic squamous cell carcinoma arising in sacrococcygeal pilonidal sinus: a case report series

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