Pilomatrixoma mimicking a breast neoplasm: imaging finding in an uncommon case report

Breast Pilomatrixoma in a 47-year-old Woman: Pathological and Radiological Diagnosis

“…Pilomatrixoma of the breast is very rare, originating from the hair matrix cells, and comprises 1% of all benign skin tumors. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] It could be misdiagnosed as a malignant lesion clinically, so radiological imaging and histopathological findings should be evaluated together. 1 They are usually asymptomatic, have a firm consistency, and are revealed as solitary, slow-growing, non-tender lesions measuring 3mm to 30mm in diameter.…”

“…Pilomatrixoma (calcifying epithelioma of Malherbe) was first described by Malherbe and Chenatais in 1880 as a sebaceous gland origin, but in 1961, Forbis and Helwig proved that it originates from the hair matrix and was considered as a hamartoma. [1][2][3][4][5][6][7][8][9][10][11] Pilomatrixoma is a benign adnexal tumor of hair matrix cells. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The exact prevalence is unknown, but it accounts for nearly less than 1% of all benign skin tumors.…”

“…[1][2][3][4][5][6][7][8][9][10][11] Pilomatrixoma is a benign adnexal tumor of hair matrix cells. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The exact prevalence is unknown, but it accounts for nearly less than 1% of all benign skin tumors. 13 The most common sites are the head, neck, and upper extremities.…”

“…It can occur at any age but is more common in children and young adults, and again after the age of 60, with a higher incidence in women. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] The etiology of pilomatrixoma is unclear, but it may be related to the inflammatory process as a result of repeated traumas. 1,3,8,10 To the best of our knowledge, there are only a few reported cases in the literature for breast pilomatrixoma.…”

“…1,3,8,10 To the best of our knowledge, there are only a few reported cases in the literature for breast pilomatrixoma. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Herein, we report the case of a 47-year-old woman presenting with a right breast mass diagnosed as breast pilomatrixoma, followed by a brief discussion of its histopathological and imaging characteristic.…”