Pilomatrix carcinoma with multiple visceral metastases: Report of a case

Niedermeyer, Hans P.; Peris, Ketty; Höfler, Heinz

doi:10.1002/(sici)1097-0142(19960401)77:7<1311::aid-cncr13>3.0.co;2-4

Cited by 76 publications

(60 citation statements)

References 22 publications

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“…İnvaziv formları ekarte etmek için dikkatli histolojik çalışma yapmak gerekir; çünkü nadir olmasına rağmen imkânsız değildir. Malin formlarda daha büyük epitel hücre komponenti, indiferansiye bazoloid hücreler kümesi, atipik hücreler, kan damarı ve kapsüler doku invazyonu görülür 12 . Literatürde metastaz gösteren malin pilomatriksoma olguları bildirilmiştir 3,12 .…”

Section: Discussionunclassified

“…Malin formlarda daha büyük epitel hücre komponenti, indiferansiye bazoloid hücreler kümesi, atipik hücreler, kan damarı ve kapsüler doku invazyonu görülür 12 . Literatürde metastaz gösteren malin pilomatriksoma olguları bildirilmiştir 3,12 . Tüm hastalarımızın histopatolojik bulguları tipik pilomatriksoma ile uyumluydu ve malin transformasyon göstermiyordu.…”

Section: Discussionunclassified

“…Literatürlerde nadir de olsa tümörün malin formları gösterilmiştir. Pilomatriks karsinoma olarak adlandırılan bu malin formların akciğer, kemik, beyin, deri, lenf nodu abdominal organlara metastaz yaptığı bildirilmiştir 7,10,11,12 . Literatürde pilomatriksoma ile ilgili kısıtlı veriler bulunmaktadır.…”

Section: Introductionunclassified

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Çocuklarda Pilomatriksoma (Kalsifiye Epitelyoma)

Varlıklı¹,

Yıldız²,

Çetin³

et al. 2013

Turkderm

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ÖzetAmaç: Pilomatriksoma veya Malherbe'nin kalsifiye epitelioması kılın pluripotent prekürsör matriks hücrelerinden köken alan, nadir görülen, iyi huylu, sınırlı, kalsifiye epitelyal bir tümördür. Genellikle baş boyun ve üst ekstremitelerde, deri veya deri altında, semptom vermeyen nodül olarak görülür. Bu klinik çalışmada, 20 olgudaki tecrübelerimiz ışığında tümörün epidemiyolojisinin, klinik ve histopatolojik bulgularının, ayırıcı tanısının ve tedavi sonuçlarının tartışılması hedeflenmiştir. Gereç ve Yöntem: Bu çalışmada, 2005-2012 yılları arasında çocuk cerrahisi kliniklerinde deri altı kitlelere eksizyonel biyopsi uygulanan ve patolojik olarak pilomatriksoma tanısı alan 20 olgu retrospektif olarak incelendi. Bulgular: Toplamda 20 olgumuzun 12'si kız (%60), 8'i erkekti (%40). Tanı aldıklarında hastaların ortalama yaşı 9,6 yıldı. Olgularımızın 18 tanesi (%90) tek nodül şeklinde, 2 tanesi (%10) ayrı lokalizasyonlarda çift nodül şeklindeydi. Tümör lokalizasyonları itibari ile %54,5'ü baş-boyun, %31,8'i ekstremite ve %13,6'sı gövdede bulunuyordu. Sonuç: Pilomatriksoma, sık olmamasına rağmen daha çok çocuklarda ve adelosanlarda görülen cerrahi eksizyon ile tedavi edilebilen benin bir deri tümörüdür. Bu olguların tekrarlama ve hatta metastaz riski taşıyan malin formunun atlanmaması için histopatolojik ve klinik özelliklerinin dikkatle değerlendirilmesi gereklidir (Türk derm 2013; 47: 84-7). Anah tar Ke li me ler: Pilomatriksoma, çocuklar Sum maryBackground and Design: Pilomatrixoma calcifying epithelioma of Malherbe is a rare, benign, limited, calcifying epithelial neoplasm that arises from the hair pluripotent precursor matrix cells. It is usually seen in the head and neck and the upper extremities, in the dermis or subcutaneous tissues as an asymptomatic nodule. In this study, we discuss the epidemiology of the tumor, clinical and histopathological findings, differential diagnosis and treatment outcome of pilomatrixoma in the light of our experiences with 20 cases. Materials and Methods: We retrospectively evaluated a total of 20 cases diagnosed with pilomatrixoma with a pathology evaluation after excisional biopsy of the subcutaneous mass at pediatric surgery clinics between 2005 and 2012. Results: Our 20 patients consisted of 12 females (60%) and 8 males (40%). The mean age at the time of diagnosis was 9.6 years. There was a single nodule in 18 cases (90%) and two nodules in separate places in 2 cases (10%). The tumor localization was in the head and neck in 54.5%, the extremities in 31.8%, and the trunk in 13.6%. Conclusion: Pilomatrixomas are rare but usually seen in children and adolescents and this benign skin tumor can be treated with surgical excision. Histopathological and clinical features should be evaluated carefully to prevent missing the malignant form that carries a risk of recurrence and even metastasis. (Turkderm 2013; 47: 84-7)

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Section: Discussionunclassified

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Çocuklarda Pilomatriksoma (Kalsifiye Epitelyoma)

Varlıklı¹,

Yıldız²,

Çetin³

et al. 2013

Turkderm

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“…In contrast, pilomatrix carcinoma shows broad geographic necrosis with an infiltrative margin and cytological alterations, including fully transformed malignant change. 90,91,[103][104][105][106][107][108][109][110][111][112][113][114][115] Matrical differentiation may only be focal in these lesions. Tumors have the potential to spread to regional lymph nodes and produce fatal disseminated metastatic disease.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Tumors have the potential to spread to regional lymph nodes and produce fatal disseminated metastatic disease. 107,115 There is a locally invasive form of aggressive pilomatrixoma that shows local recurrence, but not distant metastasis. The histomorphology constitutes a point on a spectrum from the benign pilomatricoma to its malignant metastasizing counterpart.…”

Section: Clinical Featuresmentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Radiology Quiz Case 2: Diagnosis

2011

Arch Otolaryngol Head Neck Surg

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Pilomatrix carcinoma with multiple visceral metastases: Report of a case

Abstract: Pilomatrix carcinoma is very rare and usually behaves like a low-grade, malignant lesion with a tendency to recur. This patient's tumor is unique because of its highly aggressive behavior and visceral metastases.

Cited by 76 publications

References 22 publications

Çocuklarda Pilomatriksoma (Kalsifiye Epitelyoma)

Çocuklarda Pilomatriksoma (Kalsifiye Epitelyoma)

Malignant adnexal neoplasms

Radiology Quiz Case 2: Diagnosis

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