Pilomatricoma-like Endometrioid Adenosquamous Carcinoma of the Ovary with Neuroendocrine Differentiation

Fang, Junming; Keh, Pacita; Katz, Linda S; Rao, M. Sambasiva

doi:10.1006/gyno.1996.0142

Cited by 15 publications

(16 citation statements)

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“…In the ovarian location, the shadow cells were described in benign pilomatrixoma in dermoid cyst (mature teratoma) [5] and in endometrioid carcinoma [9, 12], but they were not reported in basaloid carcinoma [15]. For this reason, we performed extensive sampling and we searched for preexisting teratoma or for pattern of endometrioid carcinoma (with negative result) before our final diagnosis of “pure” basaloid carcinoma was rendered.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Basaloid Carcinoma with Shadow Cell Differentiation

Zámečnı́k¹,

Jando²,

Kaščák

2014

Case Reports in Pathology

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So-called shadow cell differentiation (SCD) is typical for pilomatrixoma and other skin lesions with follicular differentiation, but it was rarely described also in some visceral carcinomas. We report a case of ovarian basaloid carcinoma with SCD. The tumor presented as a 14 cm ovarian mass in a 45-year-old woman, and therefore the adnexectomy and hysterectomy were performed. The tumor was of high stage. Multiple metastases were found in the liver, retroperitoneal and mediastinal lymph nodes, and the lung. Histologically, the tumor showed a pattern of high-grade basaloid carcinoma with numerous shadow cells. Extensive histologic examination did not reveal any glandular or preexisting teratoma component. Immunohistochemically, the tumor expressed markers of squamous cell differentiation, such as p63, cytokeratin 5/6, and high-molecular-weight keratin. Cytokeratin 7 and CA125 were positive in scattered cells of the lesion. Estrogen and progesterone receptor, vimentin, and p53 were negative. Beta-catenin showed nuclear and cytoplasmic positivity, indicating possible tumor proliferation/differentiation via Wnt signaling pathway. To our knowledge, SCD in basaloid carcinoma of the ovary was not described before. In addition to the description of the case, we review the literature on SCD in visceral carcinomas.

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Section: Discussionmentioning

confidence: 99%

Ovarian Basaloid Carcinoma with Shadow Cell Differentiation

Zámečnı́k¹,

Jando²,

Kaščák

2014

Case Reports in Pathology

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“…On the other hand, there have been 16 reported cases of visceral carcinomas with SCD, with the exception of teratomatous tumors. The primary site of these tumors includes ovary [56, 57, 58], endometrium [59, 60], colon [59, 61], gallbladder [62], urinary bladder [63, 64], stomach [65], and lung [66]. Histologically, all these cases except for one (gallbladder carcinoma) are adenosquamous carcinomas, adenocarcinomas with squamous metaplasia (adenoacanthomas), urothelial carcinomas with squamous differentiation, or squamous cell carcinomas, suggesting that shadow cells are derived from squamous/squamoid components.…”

Section: Shadow Cell Differentiationmentioning

confidence: 99%

Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Keratinization

Nakamura

2018

Dermatopathology

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Shadow cells are characterized by an eosinophilic cytoplasm and a ghost-like nuclear contour; the cell shape is preserved, in spite of nuclear disappearance. Shadow cell nests (SCNs) are frequently observed in pilomatricoma (PMX), where the transitional cells immediately adjacent to SCNs often have a crescent-shaped nucleus showing fragmentation similar to that of apoptotic bodies. They show nuclear accumulation of beta-catenin and DNA double strand breaks (as revealed by in situ 3′-tailing reaction or immunohistochemistry for single-stranded DNA [ssDNA]), while they are negative for cleaved caspase-3 or cleaved lamin A, suggesting that shadow cell differentiation (SCD) is a caspase-independent programmed cell death. SCD can be differentiated from epidermal keratinization (EK) and trichilemmal keratinization (TK) based on the expression pattern of beta-catenin, ssDNA, and caspase-14/CD138. SCD is observed not only in PMX, but also sometimes in basal cell carcinomas, gonadal teratomas, and various extra-cutaneous carcinomas. In particular, SCNs are found in 24% of endometrial adenoacanthoma and are derived from squamoid morules. This establishes a link between basaloid cells in PMX and squamoid morules in endometrial adenoacanthomas as common precursors of shadow cells. Overall, it is suggested that SCD is different from, but partly similar to, apoptosis and that SCD and EK/TK should be differentiated from the standpoint of cell death/differentiation.

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“…Although shadow cells are commonly associated with pilomatricomas and pilomatrical carcinomas, they have also been reported in cutaneous infundibular cysts, cutaneous mixed tumors, testicular pilomatricoma, intracranial dermoid cyst, ovarian endometrioid adenocarcinomas, uterine endometrioid adenocarcinomas, transitional cell carcinoma of the urinary bladder, colonic adenocarcinoma, odontogenic cysts, and craniopharyngioma. [2][3][4][5][6][7] In 1994, Zámečník and Michal 3 reported shadow cell differentiation in 3 endometrial adenocarcinomas, 2 colonic adenocarcinomas, and 1 case of atypical endometrial hyperplasia. In a later study, they found shadow cells in 6 of 100 endometrial adenocarcinomas and cautioned that shadow cell differentiation alone was not diagnostic of pilomatricoma or pilomatrical carcinoma, particularly in extracutaneous locations.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastasis of Ovarian Carcinoma With Shadow Cells Mimicking a Primary Pilomatrical Neoplasm

Lalich

Tawfik

Chapman

et al. 2010

The American Journal of Dermatopathology

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Shadow cells are characteristic of pilomatricoma, although they have been described in other cutaneous and visceral neoplasms, particularly endometrioid adenocarcinomas of the female genital tract. We describe a metastasis of an ovarian endometrioid adenocarcinoma with shadow cells to the skin that was initially misinterpreted as a pilomatricoma. We compare the histology of the ovarian neoplasm to 21 pilomatricomas. This is the first reported case of a cutaneous metastasis of a visceral neoplasm mimicking a primary pilomatrical neoplasm.

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Pilomatricoma-like Endometrioid Adenosquamous Carcinoma of the Ovary with Neuroendocrine Differentiation

Cited by 15 publications

References 0 publications

Ovarian Basaloid Carcinoma with Shadow Cell Differentiation

Ovarian Basaloid Carcinoma with Shadow Cell Differentiation

Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Keratinization

Cutaneous Metastasis of Ovarian Carcinoma With Shadow Cells Mimicking a Primary Pilomatrical Neoplasm

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