Pilocytic Astrocytoma in a Cat

Sant’Ana, Fabiano José Ferreira de; Serákides, Rogéria; Graça, Dominguita Lühers

doi:10.1354/vp.39-6-759

Cited by 15 publications

(16 citation statements)

References 7 publications

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“…4,8,9 Osseous metaplasia has been reported in various neoplasms in dogs and cats. 3,4,8,28 It has also been reported in mice with metal ear tags, 15 in the retinal pigmented epithelium of phthisical eyes, 17 and in an otherwise normal canine eye. 20 Metaplasia results not from a change in phenotype of differentiated cells but from reprogramming of either stem cells in normal tissues or undifferentiated mesenchymal cells in connective tissue.…”

Section: Discussionmentioning

confidence: 87%

Malignant Pilomatricoma in 3 Dogs

et al. 2010

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Malignant pilomatricoma, also known as pilomatrix carcinoma and calcifying epitheliocarcinoma (in the human literature), has been considered a rare neoplasm of dogs. The authors present 3 canine cases of malignant pilomatricoma (2 with distant metastasis) and compare its behavior with reported behavior. Cases include an 8-year-old spayed female Airedale Terrier, a 7-year-old male Bassett Hound, and a 12-year-old intact male Giant Schnauzer. In all cases, the histologic features included trabeculae of basaloid cells, abrupt keratinization, ''ghost'' or ''shadow'' cells, and various features of malignancy consistent with a diagnosis of malignant pilomatricoma. Metastasis, including that to bone, was confirmed in 2 cases. Four cases of the 13 canine pilomatricomas diagnosed within a 24-month period (2006)(2007)(2008) at the Ohio State University (2 of which are discussed in this report) were classified as malignant, which suggests that malignant pilomatricoma is more common than previously reported.

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Section: Discussionmentioning

confidence: 87%

Malignant Pilomatricoma in 3 Dogs

et al. 2010

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“…Vimentin is also usually positive. 19 Five of 7 morphologically diagnosed feline astrocytomas also had positive GFAP cytoplasmic staining, 4,26,106 but NSE positivity was documented only in 1 of 5 studies 26 and S100 in 2. Positive p53 staining was recorded in 1 case.…”

Section: Astrocytic Tumorsmentioning

confidence: 98%

Diagnostic Immunohistochemistry of Canine and Feline Intracalvarial Tumors in the Age of Brain Biopsies

2013

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The focus of immunohistochemistry as applied to nervous system tumors is in identifying the neoplasm present and evaluating margins between normal and neoplastic tissue. Although not always utilized by specialists in neuropathology, immunohistochemistry remains useful to resolve concerns about the differentiation and rate of tumor growth. The aims of this review are to discuss the utility of immunohistochemical reagents currently used in diagnosis of canine and feline intracalvarial tumors, to indicate the applicability of some tests currently used in human nervous system tumors for domestic species, and to evaluate a few less commonly used reagents. A panel of biomarkers is usually needed to confirm a diagnosis, with groups of reagents for leptomeningeal, intraparenchymal, and ventricular neoplasms. In the future, signature genetic alterations found among feline and canine brain tumors-as correlated prospectively with diagnosis, rate of enlargement, or response to treatment-may result in new immunohistochemical reagents to simplify the task of diagnosis. Prospective studies determining the type and proportion of stem cell marker expression on patient longevity are likely to be fruitful and suggest new therapies. Due to increased frequency of biopsy or partial resection of tumors from the living patient, biomarkers are needed to serve as accurate prognostic indicators and assist in determining the efficacy of developing therapeutic options in nervous system tumors of dogs and cats.

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“…S100 is used in the diagnosis of melanoma in humans and will also stain feline melanomas 13,15 . It is, however, not specific for melanocytes and is also expressed in a wide array of feline cells, structures and neoplasms including astrocytes, chondrocytes, adipocytes, Sertoli cells, Leydig cells, histiocytes/macrophages, adrenal medulla, pars intermedia of the pituitary, pacinian corpuscles, astrocytoma, ganglioneuroblastoma, neuroendocrine carcinoma, peripheral nerve sheath tumor, meningioma, ependymoma, rhabdomyosarcoma, and ocular post‐traumatic sarcomas 11,16–29 . A small percentage of human melanomas may express muscle markers (website immunoquery.com reported by Ohsie et al.…”

Section: Discussionmentioning

confidence: 99%

Ocular myxoid leiomyosarcoma in a cat

Labelle¹,

Holmberg²

2010

Veterinary Ophthalmology

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A case of myxoid leiomyosarcoma likely of iris dilator muscle origin in the enucleated eye of a 6-year-old domestic short haired cat is reported. The poorly demarcated mass expanded the iris, partially filled the globe and extended into the optic nerve. The mass was composed of spindle cells separated by abundant matrix positive for mucopolysaccharides with alcian blue. The neoplastic cells were immunoreactive for smooth muscle actin (SMA), S100 and vimentin, and negative for cytokeratin, Melan-A, glial fibrillary protein (GFAP) and desmin. There was no evidence of recurrence or metastasis 6 months after enucleation.

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Pilocytic Astrocytoma in a Cat

Cited by 15 publications

References 7 publications

Malignant Pilomatricoma in 3 Dogs

Malignant Pilomatricoma in 3 Dogs

Diagnostic Immunohistochemistry of Canine and Feline Intracalvarial Tumors in the Age of Brain Biopsies

Ocular myxoid leiomyosarcoma in a cat

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