Pillar[5]arene based supramolecular polymer for a singlet oxygen reservoir

Abstract

A new diphenylanthracene derivative (bis(5-cyanopentyl) 4,4'-(anthracene-9,10-diyl)dibenzoate) has been designed and synthesized, which can host–guest complex with a novel pillar[5]arene dimer. The strong host–guest interaction of them has been proved by...

Dual‐Responsive Drug‐Delivery System Based on PEG‐Functionalized Pillararenes Containing Disulfide and Amido Bonds for Cancer Theranostics

“…Compound 1 was synthesized by our previous reported method. [23] Dulbecco's modified Eagle's medium (DMEM) and fetal bovine serum (FBS) were purchased from PAA Laboratories (Austria). Other organic reagents were purchased from Meryer Chemical Inc and TCI Chemical Inc. Human cervical cancer cells (HeLa cells) were ordered from Shanghai Institute of Biochemistry and Cell Biology (Shanghai, P. R. China).…”

“…[20][21] Meanwhile the electron-rich property of the cavities gives them superior host-guest binding abilities. [22][23][24] In addition, the biggest bright spot of pillararenes is undoubtedly the easily functionalized side chains, which facilitates the design of pillararenes with specific functionality. [25][26][27][28] In this context, using more hydrophilic polymer side chains like PEG to modify pillararenes is an efficient path to improve the water solubility and self-assembly capability of pillararenes.…”

“…The unique hydrophobic internal cavities of pillararenes give them good drug‐encapsulation ability [20–21] . Meanwhile the electron‐rich property of the cavities gives them superior host‐guest binding abilities [22–24] . In addition, the biggest bright spot of pillararenes is undoubtedly the easily functionalized side chains, which facilitates the design of pillararenes with specific functionality [25–28] .…”

The design strategy for pillararene based active targeted drug delivery systems

“…18,24 The electron-rich cavity endows pillararenes with good host-guest properties to complex with a series of electrondeficient groups. [25][26][27][28][29] Dazzling structural variability of side chains could regulate the amphiphilicity, water solubility and stimuli responsiveness of pillararenes. [30][31][32] After more than ten years of development, pillararenes have become an important player in DDSs, because they can not only self-assemble into nanocarriers with well-defined structures to load various types of drugs, but also can display different environmental stimuliresponsiveness to release drugs.…”

Supramolecular polymer network gels constructed by a pillararene-containing polymer and their applications in adhesion between semihard materials

“…7,[23][24][25][26][27][28] Pillararenes [29][30][31][32][33] are an emerging type of macrocyclic hosts after crown ethers, cyclodextrins, calixarenes, and cucurbiturils. On account of their excellent hostguest recognition properties, pillararenes have been applied in a variety of fields, for example, biomedical matrials, 34,35 supramolecular polymers, 36,37 light-harvesting systems, [38][39][40][41] adsorption, 42,43 encryption of information, 44 etc. However, supramolecular adhesive materials based on pillararenes have rarely been reported, 6,45 let alone adhesion between hard materials.…”