Pillar[4]arene[1]quinone-based pseudo[3]rotaxanes by cooperative Host-Guest binding

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

“…In recent years, one such promising avenue has been the use of pillar­[ n ]­arenes as anti-biofilm agents. Pillar­[ n ]­arenes, a class of macrocyclic host molecules with a distinctive pillar-shaped architecture, exhibit remarkable host–guest interactions, enabling them to complex with a diverse range of guest molecules. − Their significant properties stem from their unique structural features, rendering them promising candidates for various applications in supramolecular chemistry. − Modifiable functionalities and unique structural characteristics of pillar­[ n ]­arenes hold promise for developing materials specifically tailored for biological applications. − Pillar­[ n ]­arenes have been shown to possess inherent antimicrobial properties against a broad range of planktonic bacteria, including both Gram-positive and Gram-negative strains. , Biocompatibility and safety are the essential aspects of any potential anti-biofilm agents for human use. Preliminary investigations suggest pillar­[ n ]­arenes and their derivatives as safe and biocompatible agents; hence they exhibit low cytotoxicity and minimal adverse effects. − The unique properties of pillar­[ n ]­arenes extend beyond their antimicrobial potential, encompassing artificial transmembrane transport capabilities. − Pillar­[ n ]­arene derivatives possess the capacity to facilitate the transport of specific molecules across cell membranes.…”