Pili Annulati Occurring as a Family Disorder

Reyn, Arne; Haxthausen, H.

doi:10.1111/j.1365-2133.1934.tb10200.x

Cited by 13 publications

(16 citation statements)

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“…Therefore, we consider it rather unlikely that there is a direct association between PA and AA, mainly for two reasons. First, in none ofthe PA families studied here, or in the patients reported elsewhere, could two or more individuals affected by both hair disorders be detected (11)(12)(13)(14)(15)(16)(17)(18). Secondly, none ofthe previously published susceptibility loci for AA (25) coincide with the candidate region for PA (8,9).…”

Section: Discussionmentioning

confidence: 69%

“…Based on approximately 30 reports on PA since 1950 and 20 single case reports published prior to 1921, the simultaneous occurrence with AA has been described in only nine cases (6,(11)(12)(13)(14)(15)(16)(17)(18). In three of these previous reports an amelioration or disappearance of the PA phenotype was observed when AA became manifest and hair re-grew later on (15,18,23).…”

Section: Discussionmentioning

confidence: 90%

“…In different, mainly anecdotal, case reports, a putative aetiopathological association between these disorders has been discussed (13)(14)(15)(16)(17)(18). We provide here a systematic study on the concomitant manifestation of PA and AA.…”

Section: Discussionmentioning

confidence: 93%

“…The concomitant manifestation of PA and AA is well documented (11)(12)(13)(14)(15)(16)(17)(18). However, these were mostly single case reports and there are no studies in which extended families with PA have been analysed for the occurrence of AA.…”

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confidence: 94%

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Concomitant Manifestation of Pili Annulati and Alopecia Areata: Coincidental Rather than True Association

Giehl¹,

Schmuth²,

Tosti³

et al. 2011

Acta Derm Venerol

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The autosomal dominantly inherited hair disorder pili annulati is characterized by alternating light and dark bands of the hair shaft. Concomitant manifestation of pili annulati with alopecia areata has been reported previously on several occasions. However, no systematic evaluation of patients manifesting both diseases has been performed. We studied the simultaneous or sequential occurrence of pili annulati and alopecia areata in individuals diagnosed in different European academic dermatology units. We included 162 Caucasian individuals from 14 extended families, comprising 76 affected and 86 unaffected family members. Statistical analysis showed that the frequency of alopecia areata among patients with pili annulati was higher than within the general population. Five of our patients with pili annulati have gone through severe episodes of alopecia areata. We cannot rule out that the currently unknown genetic defect underlying pili annulati might also confer an increased risk for the development of a more pronounced manifestation of alopecia areata. Based on the current data, and considering the low number within individual families of patients affected by both diseases, however, a direct association between pili annulati and alopecia areata seems unlikely.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 94%

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Concomitant Manifestation of Pili Annulati and Alopecia Areata: Coincidental Rather than True Association

Giehl¹,

Schmuth²,

Tosti³

et al. 2011

Acta Derm Venerol

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“…There is no association with hair fragility. Most reported familial cases have been inherited in an autosomal dominant fashion (Cady and Trotter, 1922;Snell and Foley, 1922;Reyn, 1934;Ashley and Jacques, 1950;McCleary and Montgomery, 1955;Dawber, 1972;Lama et al, 1988;Misciali et al, 1993). There have been no previously published genetic linkage studies of PA to date.…”

mentioning

confidence: 93%

A Gene for Pili Annulati Maps to the Telomeric Region of Chromosome 12q

Green

Fitzpatrick

Berker

et al. 2004

Journal of Investigative Dermatology

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Pili annulati (PA) is a rare hair shaft disorder characterized by discrete banding of hairs. We studied two families with PA in which the disorder segregated in an autosomal dominant fashion. All family members were clinically examined and hair samples were examined under the light microscope. In family G, of 19 individuals examined, ten were affected, over three generations. In family B, there were three affected individuals of seven examined over three generations. A genome-wide scan of family G revealed a maximum logarithm of odds (LOD) of linkage score of 3.89 at marker D12S1723 at the telomeric region of chromosome 12q. From one critical recombinant in family G, the locus was narrowed down to a 9.2 cM region between D12S367 and the end of chromosome 12q. In family B linkage at the telomeric region of chromosome 12q also revealed a maximum LOD score of 0.89 at marker D12S1723. A combined LOD score, assuming no locus heterogeneity between the families was 4.78. Frizzled 10, which is located within the region, was sequenced but we were unable to detect a mutation causing PA. This study, for the first time, identifies a genetic locus for PA.

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Ringed Hair

Montgomery¹,

Binder²

1948

Arch Derm Syphilol

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Pili Annulati Occurring as a Family Disorder

Cited by 13 publications

References 0 publications

Concomitant Manifestation of Pili Annulati and Alopecia Areata: Coincidental Rather than True Association

Concomitant Manifestation of Pili Annulati and Alopecia Areata: Coincidental Rather than True Association

A Gene for Pili Annulati Maps to the Telomeric Region of Chromosome 12q

Ringed Hair

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