Background: Breast cancer is a global public health issue and the side effects of the clinical treatment can decline the quality of life of these women. Therefore, a healthy lifestyle is essential to minimize the physical and psychological side effects of treatment. Physical activity has several benefits for breast cancer women and Pilates solo and belly dance can be an enjoyable type of physical activity for breast cancer women undergoing clinical treatment. The purpose of the study will be to provide a Pilates solo and a belly dance protocol (3x/16 weeks) for women undergoing breast cancer treatment and compare its effects with the control group. Methods: The participants will be allocated to either the intervention arm (Pilates solo or belly dance classes 3x/week for 16 weeks) or a control group (receipt of a booklet on physical activity for breast cancer patients and maintenance of habitual physical activity routine). The Pilates solo and belly dance classes will be divided into three stages: warm-up and stretching; the main stage and relaxation. Measurements of study outcomes will take place at baseline, post-intervention, 6-, 12- and 24-months (maintenance period). The data collection for both groups will occur with a questionnaire application and tests, covering general and clinical information, primary outcome will be quality of life (EORT QLQ C30 and BR23), secondary outcomes will be physical aspects as cardiorespiratory fitness (6-minute walk test and cycle ergometer), lymphedema (sum of arm circumference), physical activity (IPAQ short version), disabilities of the arm (DASH), range of motion (goniometer test), strength (dynamometer test) and flexibility (sit and reach test) and psychological aspects as depressive symptoms (BECK Inventory), body image (Body Image After Breast Cancer Questionnaire), self-esteem (Rosenberg), fatigue (FACT-F), pain (VAS), sexual function (FSFI) and sleep quality (Pittsburgh Sleep Quality Index). Discussion: In view of the high prevalence of breast cancer among women, the implementation a specific protocol of Pilates solo and belly dance for patients with breast cancer is important considering the needs to improve the quality of life, physical and psychological aspects of their life. Pilates solo and belly dance are two kinds of physical activity that involves mental and body concentration, music, upper limb movements, femininity, and social involvement. An intervention with these two physical activities could offer a choice of supportive care to breast cancer women undergoing treatment to improve quality of life, physical and psychological aspects. Trial registration: ClinicalTrials.gov Identifier: NCT03194997 (registration date: 12 August 2017). Universal Trial Number (World Health Organization): U1111-1195-1623. https://clinicaltrials.gov/ct2/show/NCT03194997