Abstract:Background: Lung cancer is a common malignant neoplasm worldwide. Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) plays as a therapeutic target in many cancers. The role PIK3R1 plays in lung cancer still remains unclear. Our study aims to explore the role of PIK3R1 in lung cancer.Methods: We used quantitative real-time PCR (qPCR) to detect the PIK3R1 mRNA expression level in our 20 paired lung cancer patients. We then used A549sh-PIK3R1, H1299sh-PIK3R1, H1650LV-PIK3R1, H292LV-PIK3R1, A549sh-PIK3R1+LV-… Show more
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